Effect of platelet-rich plasma treatment on antioxidant enzymes’ activity following hamstring injury among Malaysian athletes

The objective of the present preliminary study was to investigate the effect of platelet-rich plasma (PRP) treatment alongside rehabilitation programme compared with rehabilitation programme alone on antioxidant enzymes’ (superoxide dismutase, SOD; catalase, CAT) activity and time to return to play...

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Main Authors:	Lai, Lingling, Mohd Nahar Azmi Mohamed, Mohamed Razif Mohamed Ali, Khong, Teng-Keen, Ashril Yusof
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2016
Online Access:	http://journalarticle.ukm.my/9881/ http://journalarticle.ukm.my/9881/ http://journalarticle.ukm.my/9881/1/13_LingLing_Lai.pdf

id	ukm-9881
recordtype	eprints
spelling	ukm-98812016-12-14T06:51:08Z http://journalarticle.ukm.my/9881/ Effect of platelet-rich plasma treatment on antioxidant enzymes’ activity following hamstring injury among Malaysian athletes Lai, Lingling Mohd Nahar Azmi Mohamed, Mohamed Razif Mohamed Ali, Khong, Teng-Keen Ashril Yusof, The objective of the present preliminary study was to investigate the effect of platelet-rich plasma (PRP) treatment alongside rehabilitation programme compared with rehabilitation programme alone on antioxidant enzymes’ (superoxide dismutase, SOD; catalase, CAT) activity and time to return to play (RTP) following hamstring injury among Malaysian athletes. Participants diagnosed with grade-2 acute hamstring injury (n=10) were randomised into 2 groups of PRP treatment and rehabilitation programme (PRP-T) and rehabilitation programme alone (CON). Blood samples were collected at baseline and 2 fortnightly (week-2, W2; week-4, W4) for the biochemical assessments. Participants were certified to have recovered upon fulfilling RTP criteria. PRP-T group showed a significantly lower CAT activity compared to CON group (47.55% lower at W2, 37% lower at W4, p<0.05), while there was no significant difference in SOD activity between the groups. Although PRP-T group benefited from an earlier (~15 days) time to RTP compared to the CON group, no statistically significant difference was noted; however, the effect size was large (Cohen’s d=0.9). These findings suggested that PRP treatment alongside rehabilitation potentially reduces the degree of secondary tissue damage and facilitates muscle recovery through regulation of antioxidant enzymes, which subsequently hastens time to RTP. Athletes and coaches could consider PRP as viable treatment for hamstring injury. Penerbit Universiti Kebangsaan Malaysia 2016-05 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/9881/1/13_LingLing_Lai.pdf Lai, Lingling and Mohd Nahar Azmi Mohamed, and Mohamed Razif Mohamed Ali, and Khong, Teng-Keen and Ashril Yusof, (2016) Effect of platelet-rich plasma treatment on antioxidant enzymes’ activity following hamstring injury among Malaysian athletes. Sains Malaysiana, 45 (5). pp. 769-775. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol45num5_2016/contentsVol45num5_2016.html
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	The objective of the present preliminary study was to investigate the effect of platelet-rich plasma (PRP) treatment alongside rehabilitation programme compared with rehabilitation programme alone on antioxidant enzymes’ (superoxide dismutase, SOD; catalase, CAT) activity and time to return to play (RTP) following hamstring injury among Malaysian athletes. Participants diagnosed with grade-2 acute hamstring injury (n=10) were randomised into 2 groups of PRP treatment and rehabilitation programme (PRP-T) and rehabilitation programme alone (CON). Blood samples were collected at baseline and 2 fortnightly (week-2, W2; week-4, W4) for the biochemical assessments. Participants were certified to have recovered upon fulfilling RTP criteria. PRP-T group showed a significantly lower CAT activity compared to CON group (47.55% lower at W2, 37% lower at W4, p<0.05), while there was no significant difference in SOD activity between the groups. Although PRP-T group benefited from an earlier (~15 days) time to RTP compared to the CON group, no statistically significant difference was noted; however, the effect size was large (Cohen’s d=0.9). These findings suggested that PRP treatment alongside rehabilitation potentially reduces the degree of secondary tissue damage and facilitates muscle recovery through regulation of antioxidant enzymes, which subsequently hastens time to RTP. Athletes and coaches could consider PRP as viable treatment for hamstring injury.
format	Article
author	Lai, Lingling Mohd Nahar Azmi Mohamed, Mohamed Razif Mohamed Ali, Khong, Teng-Keen Ashril Yusof,
spellingShingle	Lai, Lingling Mohd Nahar Azmi Mohamed, Mohamed Razif Mohamed Ali, Khong, Teng-Keen Ashril Yusof, Effect of platelet-rich plasma treatment on antioxidant enzymes’ activity following hamstring injury among Malaysian athletes
author_facet	Lai, Lingling Mohd Nahar Azmi Mohamed, Mohamed Razif Mohamed Ali, Khong, Teng-Keen Ashril Yusof,
author_sort	Lai, Lingling
title	Effect of platelet-rich plasma treatment on antioxidant enzymes’ activity following hamstring injury among Malaysian athletes
title_short	Effect of platelet-rich plasma treatment on antioxidant enzymes’ activity following hamstring injury among Malaysian athletes
title_full	Effect of platelet-rich plasma treatment on antioxidant enzymes’ activity following hamstring injury among Malaysian athletes
title_fullStr	Effect of platelet-rich plasma treatment on antioxidant enzymes’ activity following hamstring injury among Malaysian athletes
title_full_unstemmed	Effect of platelet-rich plasma treatment on antioxidant enzymes’ activity following hamstring injury among Malaysian athletes
title_sort	effect of platelet-rich plasma treatment on antioxidant enzymes’ activity following hamstring injury among malaysian athletes
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2016
url	http://journalarticle.ukm.my/9881/ http://journalarticle.ukm.my/9881/ http://journalarticle.ukm.my/9881/1/13_LingLing_Lai.pdf
first_indexed	2023-09-18T19:55:59Z
last_indexed	2023-09-18T19:55:59Z
_version_	1777406532106846208

Effect of platelet-rich plasma treatment on antioxidant enzymes’ activity following hamstring injury among Malaysian athletes

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