Ameliorative effect of palm oil tocotrienol rich fraction on brain oxidative stress in fenitrothion-administered rats

Fenitrothion (FNT) usage has received much attention for its potential to promote free radicals generation and interfere with antioxidant defense system. The aim of the present study was to investigate the effect of palm oil tocotrienol rich fraction (TRF) supplementation on oxidative stress and his...

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Main Authors: Siti Balkis Budin, Izatus Shima Taib, Putri Ayu Jayusman, Hui, Hui Chiang, Anand Ramalingam, Ahmad Rohi Ghazali, Jamaludin Mohamed
Format: Article
Language:English
Published: Universiti Kebangsaan Malaysia 2014
Online Access:http://journalarticle.ukm.my/7258/
http://journalarticle.ukm.my/7258/
http://journalarticle.ukm.my/7258/1/09_Siti_Balkis.pdf
id ukm-7258
recordtype eprints
spelling ukm-72582016-12-14T06:43:33Z http://journalarticle.ukm.my/7258/ Ameliorative effect of palm oil tocotrienol rich fraction on brain oxidative stress in fenitrothion-administered rats Siti Balkis Budin, Izatus Shima Taib, Putri Ayu Jayusman, Hui, Hui Chiang Anand Ramalingam, Ahmad Rohi Ghazali, Jamaludin Mohamed, Fenitrothion (FNT) usage has received much attention for its potential to promote free radicals generation and interfere with antioxidant defense system. The aim of the present study was to investigate the effect of palm oil tocotrienol rich fraction (TRF) supplementation on oxidative stress and histological changes in rat brain induced by FNT. A total of 32 male Sprague Dawley rats divided into four groups: control group which received corn oil; TRF group was received palm oil TRF (200 mg/kg bw); FNT group administered with FNT (20 mg/kg bw) and TRF+FNT group pretreated with palm oil TRF (200 mg/kg bw) 30 min prior to administration of FNT (20 mg/kg bw). FNT and TRF were dissolved in corn oil and all supplementations were given by oral gavage once daily for 28 days. After four weeks of supplementation, TRF+FNT rats had significantly lower malondialdehyde (MDA) content and superoxide dismutase (SOD) activity but higher reduced glutathione (GSH) level and total protein level compared to FNT rats (p<0.05). However, protein carbonyl (PC) level was insignificantly lower for TRF+FNT group compared to FNT group. In conclusion, this study suggested that palm oil TRF was effective in preventing brain damage in rats. Universiti Kebangsaan Malaysia 2014-07 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/7258/1/09_Siti_Balkis.pdf Siti Balkis Budin, and Izatus Shima Taib, and Putri Ayu Jayusman, and Hui, Hui Chiang and Anand Ramalingam, and Ahmad Rohi Ghazali, and Jamaludin Mohamed, (2014) Ameliorative effect of palm oil tocotrienol rich fraction on brain oxidative stress in fenitrothion-administered rats. Sains Malaysiana, 43 (7). pp. 1031-1036. ISSN 0126-6039 http://www.ukm.my/jsm/
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description Fenitrothion (FNT) usage has received much attention for its potential to promote free radicals generation and interfere with antioxidant defense system. The aim of the present study was to investigate the effect of palm oil tocotrienol rich fraction (TRF) supplementation on oxidative stress and histological changes in rat brain induced by FNT. A total of 32 male Sprague Dawley rats divided into four groups: control group which received corn oil; TRF group was received palm oil TRF (200 mg/kg bw); FNT group administered with FNT (20 mg/kg bw) and TRF+FNT group pretreated with palm oil TRF (200 mg/kg bw) 30 min prior to administration of FNT (20 mg/kg bw). FNT and TRF were dissolved in corn oil and all supplementations were given by oral gavage once daily for 28 days. After four weeks of supplementation, TRF+FNT rats had significantly lower malondialdehyde (MDA) content and superoxide dismutase (SOD) activity but higher reduced glutathione (GSH) level and total protein level compared to FNT rats (p<0.05). However, protein carbonyl (PC) level was insignificantly lower for TRF+FNT group compared to FNT group. In conclusion, this study suggested that palm oil TRF was effective in preventing brain damage in rats.
format Article
author Siti Balkis Budin,
Izatus Shima Taib,
Putri Ayu Jayusman,
Hui, Hui Chiang
Anand Ramalingam,
Ahmad Rohi Ghazali,
Jamaludin Mohamed,
spellingShingle Siti Balkis Budin,
Izatus Shima Taib,
Putri Ayu Jayusman,
Hui, Hui Chiang
Anand Ramalingam,
Ahmad Rohi Ghazali,
Jamaludin Mohamed,
Ameliorative effect of palm oil tocotrienol rich fraction on brain oxidative stress in fenitrothion-administered rats
author_facet Siti Balkis Budin,
Izatus Shima Taib,
Putri Ayu Jayusman,
Hui, Hui Chiang
Anand Ramalingam,
Ahmad Rohi Ghazali,
Jamaludin Mohamed,
author_sort Siti Balkis Budin,
title Ameliorative effect of palm oil tocotrienol rich fraction on brain oxidative stress in fenitrothion-administered rats
title_short Ameliorative effect of palm oil tocotrienol rich fraction on brain oxidative stress in fenitrothion-administered rats
title_full Ameliorative effect of palm oil tocotrienol rich fraction on brain oxidative stress in fenitrothion-administered rats
title_fullStr Ameliorative effect of palm oil tocotrienol rich fraction on brain oxidative stress in fenitrothion-administered rats
title_full_unstemmed Ameliorative effect of palm oil tocotrienol rich fraction on brain oxidative stress in fenitrothion-administered rats
title_sort ameliorative effect of palm oil tocotrienol rich fraction on brain oxidative stress in fenitrothion-administered rats
publisher Universiti Kebangsaan Malaysia
publishDate 2014
url http://journalarticle.ukm.my/7258/
http://journalarticle.ukm.my/7258/
http://journalarticle.ukm.my/7258/1/09_Siti_Balkis.pdf
first_indexed 2023-09-18T19:49:11Z
last_indexed 2023-09-18T19:49:11Z
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