Optimisation of cinnamaldehyde-in-water nanoemulsion formulation using central composite rotatable design

Thirteen formulations of cinnamaldehyde/non-ionic surfactant/water system nanoemulsions were prepared using high-pressure homogenisation. The result showed that varying the cinnamaldehyde/surfactant ratio had effect significantly (p<0.05) to mean droplet diameter, polidispersity index, ζ-potentia...

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Main Authors:	Asmawati M. Sail, Wan Aida Wan Mustapha, Salma Mohamad Yusop, Mohamad Yusof Maskat, Ahmad Fuad Shamsuddin
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2018
Online Access:	http://journalarticle.ukm.my/12388/ http://journalarticle.ukm.my/12388/ http://journalarticle.ukm.my/12388/1/07%20Asmawati%20M.%20Sail.pdf

id	ukm-12388
recordtype	eprints
spelling	ukm-123882018-12-07T23:21:35Z http://journalarticle.ukm.my/12388/ Optimisation of cinnamaldehyde-in-water nanoemulsion formulation using central composite rotatable design Asmawati M. Sail, Wan Aida Wan Mustapha, Salma Mohamad Yusop, Mohamad Yusof Maskat, Ahmad Fuad Shamsuddin, Thirteen formulations of cinnamaldehyde/non-ionic surfactant/water system nanoemulsions were prepared using high-pressure homogenisation. The result showed that varying the cinnamaldehyde/surfactant ratio had effect significantly (p<0.05) to mean droplet diameter, polidispersity index, ζ-potential, turbidity and whiteness index, while no significant effect (p>0.05) to viscosity. The mean droplet diameter ranged from 50.48 to 106.4 nm, polydispersity index from 0.06 to 0.28 and ζ-potential from -4.11 to -6.98 mV. The smallest droplet size was produced using 5% cinnamaldehyde and 5% Tween 80. Response surface for droplet diameter showed that the higher the cinnamaldehyde and surfactant concentrations, the larger the droplet diameter, polydispersity index and whiteness index. However, the ζ-potential increased as the cinnamaldehyde concentration decreased and Tween 80 increased. Increasing the cinnamaldehyde concentration led to an increase in turbidity. Formulation of 5% cinnamaldehyde and 6.23% Tween 80 gave no observable separation of the nanoemulsion with minimum droplet size, polidispersity index, viscosity, turbidity, whiteness index and maximum ζ-potential in modulus. The stability of the optimum formulation was sustained for 10 days upon storage at 4°C. The values of droplet diameter, PDI and ζ-potential were 55.50 nm, 0.08 and -5.38 mV, respectively. Penerbit Universiti Kebangsaan Malaysia 2018-09 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/12388/1/07%20Asmawati%20M.%20Sail.pdf Asmawati M. Sail, and Wan Aida Wan Mustapha, and Salma Mohamad Yusop, and Mohamad Yusof Maskat, and Ahmad Fuad Shamsuddin, (2018) Optimisation of cinnamaldehyde-in-water nanoemulsion formulation using central composite rotatable design. Sains Malaysiana, 47 (9). pp. 1999-2008. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol47num9_2018/contentsVol47num9_2018.html
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Thirteen formulations of cinnamaldehyde/non-ionic surfactant/water system nanoemulsions were prepared using high-pressure homogenisation. The result showed that varying the cinnamaldehyde/surfactant ratio had effect significantly (p<0.05) to mean droplet diameter, polidispersity index, ζ-potential, turbidity and whiteness index, while no significant effect (p>0.05) to viscosity. The mean droplet diameter ranged from 50.48 to 106.4 nm, polydispersity index from 0.06 to 0.28 and ζ-potential from -4.11 to -6.98 mV. The smallest droplet size was produced using 5% cinnamaldehyde and 5% Tween 80. Response surface for droplet diameter showed that the higher the cinnamaldehyde and surfactant concentrations, the larger the droplet diameter, polydispersity index and whiteness index. However, the ζ-potential increased as the cinnamaldehyde concentration decreased and Tween 80 increased. Increasing the cinnamaldehyde concentration led to an increase in turbidity. Formulation of 5% cinnamaldehyde and 6.23% Tween 80 gave no observable separation of the nanoemulsion with minimum droplet size, polidispersity index, viscosity, turbidity, whiteness index and maximum ζ-potential in modulus. The stability of the optimum formulation was sustained for 10 days upon storage at 4°C. The values of droplet diameter, PDI and ζ-potential were 55.50 nm, 0.08 and -5.38 mV, respectively.
format	Article
author	Asmawati M. Sail, Wan Aida Wan Mustapha, Salma Mohamad Yusop, Mohamad Yusof Maskat, Ahmad Fuad Shamsuddin,
spellingShingle	Asmawati M. Sail, Wan Aida Wan Mustapha, Salma Mohamad Yusop, Mohamad Yusof Maskat, Ahmad Fuad Shamsuddin, Optimisation of cinnamaldehyde-in-water nanoemulsion formulation using central composite rotatable design
author_facet	Asmawati M. Sail, Wan Aida Wan Mustapha, Salma Mohamad Yusop, Mohamad Yusof Maskat, Ahmad Fuad Shamsuddin,
author_sort	Asmawati M. Sail,
title	Optimisation of cinnamaldehyde-in-water nanoemulsion formulation using central composite rotatable design
title_short	Optimisation of cinnamaldehyde-in-water nanoemulsion formulation using central composite rotatable design
title_full	Optimisation of cinnamaldehyde-in-water nanoemulsion formulation using central composite rotatable design
title_fullStr	Optimisation of cinnamaldehyde-in-water nanoemulsion formulation using central composite rotatable design
title_full_unstemmed	Optimisation of cinnamaldehyde-in-water nanoemulsion formulation using central composite rotatable design
title_sort	optimisation of cinnamaldehyde-in-water nanoemulsion formulation using central composite rotatable design
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2018
url	http://journalarticle.ukm.my/12388/ http://journalarticle.ukm.my/12388/ http://journalarticle.ukm.my/12388/1/07%20Asmawati%20M.%20Sail.pdf
first_indexed	2023-09-18T20:02:30Z
last_indexed	2023-09-18T20:02:30Z
_version_	1777406941823238144

Optimisation of cinnamaldehyde-in-water nanoemulsion formulation using central composite rotatable design

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