Expression of leptin and leptin receptors in colorectal cancer—an immunohistochemical study

Obesity is demonstrated to be a risk factor in the development of cancers of various organs, such as colon, prostate, pancreas and so on. Leptine (LEP) is the most renowned of the adipokines. As a hormone, it mediates its effect through leptin receptor (LEPR) which is widely expressed in various tis...

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Main Authors:	Abdulrazzaq, Saad Mohammed, Harun, Norra, Ashour, Abdelkader Elbadawy Abbas, Mohd Kasmuri, Mohd Hanif, Mizan, Shaikh
Format:	Article
Language:	English English English
Published:	PeerJ, Inc 2019
Subjects:	RB Pathology
Online Access:	http://irep.iium.edu.my/76384/ http://irep.iium.edu.my/76384/ http://irep.iium.edu.my/76384/ http://irep.iium.edu.my/76384/1/peerj-%202019%20Leptin%20%26%20Colon%20%20cancer7624.pdf http://irep.iium.edu.my/76384/7/76384_Expression%20of%20leptin%20and%20leptin%20receptors_scopus.pdf http://irep.iium.edu.my/76384/8/76384_Expression%20of%20leptin%20and%20leptin%20receptors_wos.pdf

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spelling	iium-763842019-12-17T02:41:10Z http://irep.iium.edu.my/76384/ Expression of leptin and leptin receptors in colorectal cancer—an immunohistochemical study Abdulrazzaq, Saad Mohammed Harun, Norra Ashour, Abdelkader Elbadawy Abbas Mohd Kasmuri, Mohd Hanif Mizan, Shaikh RB Pathology Obesity is demonstrated to be a risk factor in the development of cancers of various organs, such as colon, prostate, pancreas and so on. Leptine (LEP) is the most renowned of the adipokines. As a hormone, it mediates its effect through leptin receptor (LEPR) which is widely expressed in various tissues including colon mucosa. In this study, we have investigated the degree of expression of LEP and LEPR in colorectal cancer (CRC). We collected 44 surgically resected colon cancer tissues along with normal adjacent colon tissue (NACT) from a sample of CRC patients from the Malaysian population and looked for leptin and leptin receptors using immunohistochemistry (IHC). All the samples showed low presence of both LEP and LEPR in NACT, while both LEP and LEPR were present at high intensity in the cancerous tissues with 100% and 97.7% prevalence, respectively. Both were sparsed in the cytoplasm and were concentrated beneath the cell membrane. However, we did not find any significant correlation between their expression and pathological parameters like grade, tumor size, and lymph node involvement. Our study further emphasizes the possible causal role of LEP andmLEPR with CRC, and also the prospect of using LEPR as a possible therapeutic target. PeerJ, Inc 2019-10 Article PeerReviewed application/pdf en http://irep.iium.edu.my/76384/1/peerj-%202019%20Leptin%20%26%20Colon%20%20cancer7624.pdf application/pdf en http://irep.iium.edu.my/76384/7/76384_Expression%20of%20leptin%20and%20leptin%20receptors_scopus.pdf application/pdf en http://irep.iium.edu.my/76384/8/76384_Expression%20of%20leptin%20and%20leptin%20receptors_wos.pdf Abdulrazzaq, Saad Mohammed and Harun, Norra and Ashour, Abdelkader Elbadawy Abbas and Mohd Kasmuri, Mohd Hanif and Mizan, Shaikh (2019) Expression of leptin and leptin receptors in colorectal cancer—an immunohistochemical study. PeerJ — the Journal of Life and Environmental Sciences, 2019 (10). pp. 1-18. ISSN 2167-8359 https://peerj.com/articles/7624/ 10.7717/peerj.7624
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	RB Pathology
spellingShingle	RB Pathology Abdulrazzaq, Saad Mohammed Harun, Norra Ashour, Abdelkader Elbadawy Abbas Mohd Kasmuri, Mohd Hanif Mizan, Shaikh Expression of leptin and leptin receptors in colorectal cancer—an immunohistochemical study
description	Obesity is demonstrated to be a risk factor in the development of cancers of various organs, such as colon, prostate, pancreas and so on. Leptine (LEP) is the most renowned of the adipokines. As a hormone, it mediates its effect through leptin receptor (LEPR) which is widely expressed in various tissues including colon mucosa. In this study, we have investigated the degree of expression of LEP and LEPR in colorectal cancer (CRC). We collected 44 surgically resected colon cancer tissues along with normal adjacent colon tissue (NACT) from a sample of CRC patients from the Malaysian population and looked for leptin and leptin receptors using immunohistochemistry (IHC). All the samples showed low presence of both LEP and LEPR in NACT, while both LEP and LEPR were present at high intensity in the cancerous tissues with 100% and 97.7% prevalence, respectively. Both were sparsed in the cytoplasm and were concentrated beneath the cell membrane. However, we did not find any significant correlation between their expression and pathological parameters like grade, tumor size, and lymph node involvement. Our study further emphasizes the possible causal role of LEP andmLEPR with CRC, and also the prospect of using LEPR as a possible therapeutic target.
format	Article
author	Abdulrazzaq, Saad Mohammed Harun, Norra Ashour, Abdelkader Elbadawy Abbas Mohd Kasmuri, Mohd Hanif Mizan, Shaikh
author_facet	Abdulrazzaq, Saad Mohammed Harun, Norra Ashour, Abdelkader Elbadawy Abbas Mohd Kasmuri, Mohd Hanif Mizan, Shaikh
author_sort	Abdulrazzaq, Saad Mohammed
title	Expression of leptin and leptin receptors in colorectal cancer—an immunohistochemical study
title_short	Expression of leptin and leptin receptors in colorectal cancer—an immunohistochemical study
title_full	Expression of leptin and leptin receptors in colorectal cancer—an immunohistochemical study
title_fullStr	Expression of leptin and leptin receptors in colorectal cancer—an immunohistochemical study
title_full_unstemmed	Expression of leptin and leptin receptors in colorectal cancer—an immunohistochemical study
title_sort	expression of leptin and leptin receptors in colorectal cancer—an immunohistochemical study
publisher	PeerJ, Inc
publishDate	2019
url	http://irep.iium.edu.my/76384/ http://irep.iium.edu.my/76384/ http://irep.iium.edu.my/76384/ http://irep.iium.edu.my/76384/1/peerj-%202019%20Leptin%20%26%20Colon%20%20cancer7624.pdf http://irep.iium.edu.my/76384/7/76384_Expression%20of%20leptin%20and%20leptin%20receptors_scopus.pdf http://irep.iium.edu.my/76384/8/76384_Expression%20of%20leptin%20and%20leptin%20receptors_wos.pdf
first_indexed	2023-09-18T21:47:57Z
last_indexed	2023-09-18T21:47:57Z
_version_	1777413576236990464

Expression of leptin and leptin receptors in colorectal cancer—an immunohistochemical study

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