Nanoindentation measurement on interstitial and osteon of bone with osteogenesis imperfecta-type III

"Osteogenesis imperfecta (OI) is one of the genetic disorder which was characterized by bone fragility. Previous studies reported that there are several mechanical properties has been used to investigate the strength of OI bone. However, little data is yet available to describe bone material p...

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Main Authors:	Azizan, Nurul Azira, Basarudin, Khairul Salleh, Mat Som, Mohd Hanafi, Khan, S.F., Sulaiman, A. Razak, Awang, Shukrimi
Format:	Article
Language:	English English
Published:	Zibeline International Publishing Sdn. Bhd. 2019
Subjects:	RD701 Orthopedics
Online Access:	http://irep.iium.edu.my/75429/ http://irep.iium.edu.my/75429/ http://irep.iium.edu.my/75429/ http://irep.iium.edu.my/75429/13/75429%20Nanoindentation%20measurement%20on%20interstitial.pdf http://irep.iium.edu.my/75429/14/75429%20Nanoindentation%20measurement%20on%20interstitial%20SCOPUS.pdf

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recordtype	eprints
spelling	iium-754292019-11-21T03:22:54Z http://irep.iium.edu.my/75429/ Nanoindentation measurement on interstitial and osteon of bone with osteogenesis imperfecta-type III Azizan, Nurul Azira Basarudin, Khairul Salleh Mat Som, Mohd Hanafi Khan, S.F. Sulaiman, A. Razak Awang, Shukrimi RD701 Orthopedics "Osteogenesis imperfecta (OI) is one of the genetic disorder which was characterized by bone fragility. Previous studies reported that there are several mechanical properties has been used to investigate the strength of OI bone. However, little data is yet available to describe bone material properties in individuals with this disorder for type III alone. Therefore, the aim of this study is to investigate the mechanical properties in individual with OI bone type III at interstitial and osteon. Bone tissue reduced modulus and hardness were measured by nanoindentation in three specimens with total 40 indents. These properties were compared between osteogenesis imperfecta types III for interstitial and osteonal microstructural regions. Individual with osteogenesis imperfecta type III had higher hardness and reduced modulus at interstitial rather than osteonal bone regions. Overall, the mean and standard deviation of hardness is 0.6 ± 0.11 GPa, while 0.44± 0.06 GPa for osteon. The current study presents the dataset describing the bone material properties in individual with Osteogenesis Imperfecta Type III. Results indicate that intrinsic bone tissues properties were affected by phenotype. Knowledge on the mechanical properties of severity osteogenesis imperfecta may help to assist the model and prevent the fracture risk for those having this disorder." Zibeline International Publishing Sdn. Bhd. 2019-08 Article PeerReviewed application/pdf en http://irep.iium.edu.my/75429/13/75429%20Nanoindentation%20measurement%20on%20interstitial.pdf application/pdf en http://irep.iium.edu.my/75429/14/75429%20Nanoindentation%20measurement%20on%20interstitial%20SCOPUS.pdf Azizan, Nurul Azira and Basarudin, Khairul Salleh and Mat Som, Mohd Hanafi and Khan, S.F. and Sulaiman, A. Razak and Awang, Shukrimi (2019) Nanoindentation measurement on interstitial and osteon of bone with osteogenesis imperfecta-type III. Journal of Mechanical Engineering Research and Developments, 42 (4). pp. 168-171. ISSN 1024-1752 https://jmerd.org.my/jmerd-04-2019-168-171/ 10.26480/jmerd.04.2019.168.171
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RD701 Orthopedics
spellingShingle	RD701 Orthopedics Azizan, Nurul Azira Basarudin, Khairul Salleh Mat Som, Mohd Hanafi Khan, S.F. Sulaiman, A. Razak Awang, Shukrimi Nanoindentation measurement on interstitial and osteon of bone with osteogenesis imperfecta-type III
description	"Osteogenesis imperfecta (OI) is one of the genetic disorder which was characterized by bone fragility. Previous studies reported that there are several mechanical properties has been used to investigate the strength of OI bone. However, little data is yet available to describe bone material properties in individuals with this disorder for type III alone. Therefore, the aim of this study is to investigate the mechanical properties in individual with OI bone type III at interstitial and osteon. Bone tissue reduced modulus and hardness were measured by nanoindentation in three specimens with total 40 indents. These properties were compared between osteogenesis imperfecta types III for interstitial and osteonal microstructural regions. Individual with osteogenesis imperfecta type III had higher hardness and reduced modulus at interstitial rather than osteonal bone regions. Overall, the mean and standard deviation of hardness is 0.6 ± 0.11 GPa, while 0.44± 0.06 GPa for osteon. The current study presents the dataset describing the bone material properties in individual with Osteogenesis Imperfecta Type III. Results indicate that intrinsic bone tissues properties were affected by phenotype. Knowledge on the mechanical properties of severity osteogenesis imperfecta may help to assist the model and prevent the fracture risk for those having this disorder."
format	Article
author	Azizan, Nurul Azira Basarudin, Khairul Salleh Mat Som, Mohd Hanafi Khan, S.F. Sulaiman, A. Razak Awang, Shukrimi
author_facet	Azizan, Nurul Azira Basarudin, Khairul Salleh Mat Som, Mohd Hanafi Khan, S.F. Sulaiman, A. Razak Awang, Shukrimi
author_sort	Azizan, Nurul Azira
title	Nanoindentation measurement on interstitial and osteon of bone with osteogenesis imperfecta-type III
title_short	Nanoindentation measurement on interstitial and osteon of bone with osteogenesis imperfecta-type III
title_full	Nanoindentation measurement on interstitial and osteon of bone with osteogenesis imperfecta-type III
title_fullStr	Nanoindentation measurement on interstitial and osteon of bone with osteogenesis imperfecta-type III
title_full_unstemmed	Nanoindentation measurement on interstitial and osteon of bone with osteogenesis imperfecta-type III
title_sort	nanoindentation measurement on interstitial and osteon of bone with osteogenesis imperfecta-type iii
publisher	Zibeline International Publishing Sdn. Bhd.
publishDate	2019
url	http://irep.iium.edu.my/75429/ http://irep.iium.edu.my/75429/ http://irep.iium.edu.my/75429/ http://irep.iium.edu.my/75429/13/75429%20Nanoindentation%20measurement%20on%20interstitial.pdf http://irep.iium.edu.my/75429/14/75429%20Nanoindentation%20measurement%20on%20interstitial%20SCOPUS.pdf
first_indexed	2023-09-18T21:46:44Z
last_indexed	2023-09-18T21:46:44Z
_version_	1777413500295970816

Nanoindentation measurement on interstitial and osteon of bone with osteogenesis imperfecta-type III

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