Periodic periodic assessment of antenatal and post natal serum Endothelin-1 (ET-1) and Nitric Oxide (NO) levels in hypertensive disorders of pregnancy (HDP)

Hypertensive Disorders of Pregnancy (HDP) is an independent risk factor of cardiovascular (CVS) disease with endothelial dysfunction postulated to be the pathophysiology. Endothelin-1 (ET-1), a potent vasoconstrictor, has been identified as a pivotal mediator in HDP. Disturbances in nitric oxide (NO...

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Main Authors:	Ismawi, Hidayatul Radziah, Abdul Razak, Tariq, Jamani, Nurjasmine Aida, Mohd Zainudin, Maizura
Format:	Article
Language:	English
Published:	International Islamic University Malaysia 2019
Subjects:	R Medicine (General) RB Pathology RC Internal medicine RG Gynecology and obstetrics
Online Access:	http://irep.iium.edu.my/73778/ http://irep.iium.edu.my/73778/ http://irep.iium.edu.my/73778/3/73778%20Periodic%20periodic%20assessment%20of%20antenatal.pdf

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spelling	iium-737782019-08-26T02:18:46Z http://irep.iium.edu.my/73778/ Periodic periodic assessment of antenatal and post natal serum Endothelin-1 (ET-1) and Nitric Oxide (NO) levels in hypertensive disorders of pregnancy (HDP) Ismawi, Hidayatul Radziah Abdul Razak, Tariq Jamani, Nurjasmine Aida Mohd Zainudin, Maizura R Medicine (General) RB Pathology RC Internal medicine RG Gynecology and obstetrics Hypertensive Disorders of Pregnancy (HDP) is an independent risk factor of cardiovascular (CVS) disease with endothelial dysfunction postulated to be the pathophysiology. Endothelin-1 (ET-1), a potent vasoconstrictor, has been identified as a pivotal mediator in HDP. Disturbances in nitric oxide (NO) bioavailability found in endothelial dysfunction may increase susceptibility to cardiovascular diseases such as hypertension. The study aims to determine serial ET-1 and NO levels in patients with HDP and its role in persistent endothelial dysfunction. Materials and Methods: Thirty-six pregnant women from the following categories (i) normal pregnant women (Control) (ii) chronic hypertension during pregnancy (CH) and (iii) pregnancy induced hypertension (PIH) participated in this study. Blood pressure indices measurements and sample collection were done at antepartum (32 weeks) and postpartum (8 weeks and 12 weeks). ET-1 and serum NO were measured using the Human ET-1 (Endothelin-1) ELISA Kit and Nitric Oxide (total) detection kit respectively. Results: Serum ET-1 was significantly higher in patients with CH (55.3 pg/ml) and PIH (35.6 pg/ml) compared to Control (11.8 pg/ml) during antenatal until 3 months postpartum (CH 38.3 pg/ml, PIH 29.5 pg/ml, Control 1.9 pg/ml). This was accompanied by significantly lower levels of serum NO in HDP patients. Conclusion: Persistently higher than normal levels of ET-1 and lower than normal levels of NO up to 3 months postpartum in patients with history of HDP indicate presence of persistent endothelial dysfunction despite BP normalisation in PIH patients. Long term NO/ET-1 imbalance may account for the increased CVS disease risk. International Islamic University Malaysia 2019-08 Article PeerReviewed application/pdf en http://irep.iium.edu.my/73778/3/73778%20Periodic%20periodic%20assessment%20of%20antenatal.pdf Ismawi, Hidayatul Radziah and Abdul Razak, Tariq and Jamani, Nurjasmine Aida and Mohd Zainudin, Maizura (2019) Periodic periodic assessment of antenatal and post natal serum Endothelin-1 (ET-1) and Nitric Oxide (NO) levels in hypertensive disorders of pregnancy (HDP). International Medical Journal Malaysia, 8 (2). pp. 101-106. ISSN 1823-4631 http://iiumedic.net/imjm/v1/download/volume_18_no_2/Pages-from-IMJMVol18No2-16.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General) RB Pathology RC Internal medicine RG Gynecology and obstetrics
spellingShingle	R Medicine (General) RB Pathology RC Internal medicine RG Gynecology and obstetrics Ismawi, Hidayatul Radziah Abdul Razak, Tariq Jamani, Nurjasmine Aida Mohd Zainudin, Maizura Periodic periodic assessment of antenatal and post natal serum Endothelin-1 (ET-1) and Nitric Oxide (NO) levels in hypertensive disorders of pregnancy (HDP)
description	Hypertensive Disorders of Pregnancy (HDP) is an independent risk factor of cardiovascular (CVS) disease with endothelial dysfunction postulated to be the pathophysiology. Endothelin-1 (ET-1), a potent vasoconstrictor, has been identified as a pivotal mediator in HDP. Disturbances in nitric oxide (NO) bioavailability found in endothelial dysfunction may increase susceptibility to cardiovascular diseases such as hypertension. The study aims to determine serial ET-1 and NO levels in patients with HDP and its role in persistent endothelial dysfunction. Materials and Methods: Thirty-six pregnant women from the following categories (i) normal pregnant women (Control) (ii) chronic hypertension during pregnancy (CH) and (iii) pregnancy induced hypertension (PIH) participated in this study. Blood pressure indices measurements and sample collection were done at antepartum (32 weeks) and postpartum (8 weeks and 12 weeks). ET-1 and serum NO were measured using the Human ET-1 (Endothelin-1) ELISA Kit and Nitric Oxide (total) detection kit respectively. Results: Serum ET-1 was significantly higher in patients with CH (55.3 pg/ml) and PIH (35.6 pg/ml) compared to Control (11.8 pg/ml) during antenatal until 3 months postpartum (CH 38.3 pg/ml, PIH 29.5 pg/ml, Control 1.9 pg/ml). This was accompanied by significantly lower levels of serum NO in HDP patients. Conclusion: Persistently higher than normal levels of ET-1 and lower than normal levels of NO up to 3 months postpartum in patients with history of HDP indicate presence of persistent endothelial dysfunction despite BP normalisation in PIH patients. Long term NO/ET-1 imbalance may account for the increased CVS disease risk.
format	Article
author	Ismawi, Hidayatul Radziah Abdul Razak, Tariq Jamani, Nurjasmine Aida Mohd Zainudin, Maizura
author_facet	Ismawi, Hidayatul Radziah Abdul Razak, Tariq Jamani, Nurjasmine Aida Mohd Zainudin, Maizura
author_sort	Ismawi, Hidayatul Radziah
title	Periodic periodic assessment of antenatal and post natal serum Endothelin-1 (ET-1) and Nitric Oxide (NO) levels in hypertensive disorders of pregnancy (HDP)
title_short	Periodic periodic assessment of antenatal and post natal serum Endothelin-1 (ET-1) and Nitric Oxide (NO) levels in hypertensive disorders of pregnancy (HDP)
title_full	Periodic periodic assessment of antenatal and post natal serum Endothelin-1 (ET-1) and Nitric Oxide (NO) levels in hypertensive disorders of pregnancy (HDP)
title_fullStr	Periodic periodic assessment of antenatal and post natal serum Endothelin-1 (ET-1) and Nitric Oxide (NO) levels in hypertensive disorders of pregnancy (HDP)
title_full_unstemmed	Periodic periodic assessment of antenatal and post natal serum Endothelin-1 (ET-1) and Nitric Oxide (NO) levels in hypertensive disorders of pregnancy (HDP)
title_sort	periodic periodic assessment of antenatal and post natal serum endothelin-1 (et-1) and nitric oxide (no) levels in hypertensive disorders of pregnancy (hdp)
publisher	International Islamic University Malaysia
publishDate	2019
url	http://irep.iium.edu.my/73778/ http://irep.iium.edu.my/73778/ http://irep.iium.edu.my/73778/3/73778%20Periodic%20periodic%20assessment%20of%20antenatal.pdf
first_indexed	2023-09-18T21:44:37Z
last_indexed	2023-09-18T21:44:37Z
_version_	1777413366701096960

Periodic periodic assessment of antenatal and post natal serum Endothelin-1 (ET-1) and Nitric Oxide (NO) levels in hypertensive disorders of pregnancy (HDP)

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