Recombinant sclerostin antagonizes effects of ex vivo mechanical loading in trabecular bone and increases osteocyte lacunar size
Sclerostin has emerged as an important regulator of bone mass. We have shown that sclerostin can act by targeting late osteoblasts/osteocytes to inhibit bone mineralization and to upregulate osteocyte expression of catabolic factors, resulting in osteocytic osteolysis. Here we sought to examine the...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
2018
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/69488/ http://irep.iium.edu.my/69488/1/ajpcell.00175.2017.pdf http://irep.iium.edu.my/69488/7/Scopus%20-%20Document%20details.pdf |