Extracapsular spread in oral squamous cell carcinoma and its association with GGH, CDKN3 and CBX7

PURPOSE OF STUDY: Extracapsular spread (ECS) in oral squamous cell carcinoma (OSCC) indicates tumour aggressiveness and is associated with a higher risk for tumour recurrence, loco-regional spread and distant metastasis. The identification of specific biomarkers that could predict ECS would gui...

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Main Authors: Burhanudin, Nor Aszlitah, Kallarakkal, Thomas George
Format: Conference or Workshop Item
Language:English
Published: 2018
Subjects:
Online Access:http://irep.iium.edu.my/67369/
http://irep.iium.edu.my/67369/
http://irep.iium.edu.my/67369/7/67369%20Extracapsular%20Spread%20in%20oral.pdf
id iium-67369
recordtype eprints
spelling iium-673692018-11-28T03:56:56Z http://irep.iium.edu.my/67369/ Extracapsular spread in oral squamous cell carcinoma and its association with GGH, CDKN3 and CBX7 Burhanudin, Nor Aszlitah Kallarakkal, Thomas George RK Dentistry RK318 Oral and Dental Medicine. Pathology. Diseases-Therapeutics-General Works PURPOSE OF STUDY: Extracapsular spread (ECS) in oral squamous cell carcinoma (OSCC) indicates tumour aggressiveness and is associated with a higher risk for tumour recurrence, loco-regional spread and distant metastasis. The identification of specific biomarkers that could predict ECS would guide the clinicians in the management of OSCC patients. This study aimed to determine the association between clinical and pathological parameters of OSCC patients with ECS. We also sought to investigate the expression of Gamma Glutamyl Hydrolase (GGH), Cyclin Dependent Kinase Inhibitor 3 (CDKN3) and Chromobox Homolog 7(CBX7) and their potential use as biomarkers to predict ECS in OSCC. MATERIALS AND METHODS: Association between clinicopathological parameters and expression of these markers with ECS status was analysed using chi-square test. Immunohistochemical staining with anti-GGH, anti-CDKN3 and anti-CBX7 antibodies was performed on 35 OSCC cases. RESULTS: The number of positive nodes and the highest anatomical level of nodal involvement significantly correlated with ECS (p<0.05). Immunohistochemical staining results indicated that high GGH expression was significantly associated with ECS (p<0.05), while no significant association was seen for CDKN3 and CBX7 expression with ECS. However, a trend towards significance was observed with a high level of CDKN3 and low level of CBX7 expression with ECS. CONCLUSIONS: The presence of ECS is a predictor for the pathological involvement of greater number of nodes from a higher anatomical level. GGH offers potential as a prognostic biomarker in OSCC, while the role of CDKN3 and CBX7 as prognostic markers need to be validated in a larger sample. 2018 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/67369/7/67369%20Extracapsular%20Spread%20in%20oral.pdf Burhanudin, Nor Aszlitah and Kallarakkal, Thomas George (2018) Extracapsular spread in oral squamous cell carcinoma and its association with GGH, CDKN3 and CBX7. In: 1st Joint Specialist Conference 2018, 9-11 March 2018, Kuala Lumpur. (Unpublished) https://jsc2018.github.io/assets/images/JSC2018programme_final.pdf
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic RK Dentistry
RK318 Oral and Dental Medicine. Pathology. Diseases-Therapeutics-General Works
spellingShingle RK Dentistry
RK318 Oral and Dental Medicine. Pathology. Diseases-Therapeutics-General Works
Burhanudin, Nor Aszlitah
Kallarakkal, Thomas George
Extracapsular spread in oral squamous cell carcinoma and its association with GGH, CDKN3 and CBX7
description PURPOSE OF STUDY: Extracapsular spread (ECS) in oral squamous cell carcinoma (OSCC) indicates tumour aggressiveness and is associated with a higher risk for tumour recurrence, loco-regional spread and distant metastasis. The identification of specific biomarkers that could predict ECS would guide the clinicians in the management of OSCC patients. This study aimed to determine the association between clinical and pathological parameters of OSCC patients with ECS. We also sought to investigate the expression of Gamma Glutamyl Hydrolase (GGH), Cyclin Dependent Kinase Inhibitor 3 (CDKN3) and Chromobox Homolog 7(CBX7) and their potential use as biomarkers to predict ECS in OSCC. MATERIALS AND METHODS: Association between clinicopathological parameters and expression of these markers with ECS status was analysed using chi-square test. Immunohistochemical staining with anti-GGH, anti-CDKN3 and anti-CBX7 antibodies was performed on 35 OSCC cases. RESULTS: The number of positive nodes and the highest anatomical level of nodal involvement significantly correlated with ECS (p<0.05). Immunohistochemical staining results indicated that high GGH expression was significantly associated with ECS (p<0.05), while no significant association was seen for CDKN3 and CBX7 expression with ECS. However, a trend towards significance was observed with a high level of CDKN3 and low level of CBX7 expression with ECS. CONCLUSIONS: The presence of ECS is a predictor for the pathological involvement of greater number of nodes from a higher anatomical level. GGH offers potential as a prognostic biomarker in OSCC, while the role of CDKN3 and CBX7 as prognostic markers need to be validated in a larger sample.
format Conference or Workshop Item
author Burhanudin, Nor Aszlitah
Kallarakkal, Thomas George
author_facet Burhanudin, Nor Aszlitah
Kallarakkal, Thomas George
author_sort Burhanudin, Nor Aszlitah
title Extracapsular spread in oral squamous cell carcinoma and its association with GGH, CDKN3 and CBX7
title_short Extracapsular spread in oral squamous cell carcinoma and its association with GGH, CDKN3 and CBX7
title_full Extracapsular spread in oral squamous cell carcinoma and its association with GGH, CDKN3 and CBX7
title_fullStr Extracapsular spread in oral squamous cell carcinoma and its association with GGH, CDKN3 and CBX7
title_full_unstemmed Extracapsular spread in oral squamous cell carcinoma and its association with GGH, CDKN3 and CBX7
title_sort extracapsular spread in oral squamous cell carcinoma and its association with ggh, cdkn3 and cbx7
publishDate 2018
url http://irep.iium.edu.my/67369/
http://irep.iium.edu.my/67369/
http://irep.iium.edu.my/67369/7/67369%20Extracapsular%20Spread%20in%20oral.pdf
first_indexed 2023-09-18T21:35:39Z
last_indexed 2023-09-18T21:35:39Z
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