The nephrotoxicity of concurrent use of enalapril and gentamicin in rats

Objective: The present study was aimed to assess the concurrent administration of Enalapril (ENAL) and Gentamicin (GM) in the kidney of rats. Methods: Sixty male Sprague Dawley rats were divided into 4 main groups (n=15) according to the administered dose. Each main group was further subdivided in...

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Main Authors:	Al-Ani, Imad Matloub Dally, Algantri, Khaleed R, Abdel Wahab, Emad Mohamad Nafie, Al-Mahmood, Sinan Mohammed Abdullah
Format:	Article
Language:	English English English
Published:	Innovare Academic Sciences 2018
Subjects:	QM Human anatomy QP Physiology RB Pathology RM Therapeutics. Pharmacology RM147 Administration of Drugs and Other Therapeutic Agents
Online Access:	http://irep.iium.edu.my/66221/ http://irep.iium.edu.my/66221/ http://irep.iium.edu.my/66221/ http://irep.iium.edu.my/66221/1/The%20nephrotoxicity%20of%20concurrent%20use%20of%20enalapril%20and%20gentamicin%20in%20rats.pdf http://irep.iium.edu.my/66221/7/66221_The%20nephrotoxicity%20of%20concurrent%20use%20of%20enalapril%20and%20gentamicin%20in%20rats_SCOPUS.pdf http://irep.iium.edu.my/66221/13/Scopus%20-%20Document%20details.pdf

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spelling	iium-662212019-01-25T08:06:07Z http://irep.iium.edu.my/66221/ The nephrotoxicity of concurrent use of enalapril and gentamicin in rats Al-Ani, Imad Matloub Dally Algantri, Khaleed R Abdel Wahab, Emad Mohamad Nafie Al-Mahmood, Sinan Mohammed Abdullah QM Human anatomy QP Physiology RB Pathology RM Therapeutics. Pharmacology RM147 Administration of Drugs and Other Therapeutic Agents Objective: The present study was aimed to assess the concurrent administration of Enalapril (ENAL) and Gentamicin (GM) in the kidney of rats. Methods: Sixty male Sprague Dawley rats were divided into 4 main groups (n=15) according to the administered dose. Each main group was further subdivided into three subgroups according to the day of sacrificing (n=5). Group (C) was administered daily with normal saline as control, Group (E) was treated with oral ENAL, Group (G) was treated with 75 mg/kg GM, and Group (EG) was treated with GM and ENAL. The handling of the experiment persisted daily for 15 days, and the investigational examination carried out on days 5, 10, and 15. Results: The result showed that GM nephrotoxicity augmented with the period of the experimental study, there was rising in the levels of serum creatinine and blood urea nitrogen on the 10th day and persisted in rising significantly during the period on the 15th day of the experiment. Administration of ENAL showed no significant alteration from those of controls. While the concurrent administration of ENAL and GM showed that ENAL gradually increased GM nephrotoxicity, these physiological retrogressions were accompanied with intensive renal histopathological deteriorations. Conclusion: The present study has revealed that the concurrent administration of ENAL enormously aggravated the functional and histological nephrotoxicity of GM in rats. Innovare Academic Sciences 2018-09 Article PeerReviewed application/pdf en http://irep.iium.edu.my/66221/1/The%20nephrotoxicity%20of%20concurrent%20use%20of%20enalapril%20and%20gentamicin%20in%20rats.pdf application/pdf en http://irep.iium.edu.my/66221/7/66221_The%20nephrotoxicity%20of%20concurrent%20use%20of%20enalapril%20and%20gentamicin%20in%20rats_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/66221/13/Scopus%20-%20Document%20details.pdf Al-Ani, Imad Matloub Dally and Algantri, Khaleed R and Abdel Wahab, Emad Mohamad Nafie and Al-Mahmood, Sinan Mohammed Abdullah (2018) The nephrotoxicity of concurrent use of enalapril and gentamicin in rats. Asian Journal of Pharmaceutical and Clinic Research, 11 (9). pp. 348-352. ISSN 0974-2441 E-ISSN 2455-3891 https://innovareacademics.in/journals/index.php/ajpcr/article/view/26853/15552 10.22159/ajpcr.2018.v11i9.26853
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	QM Human anatomy QP Physiology RB Pathology RM Therapeutics. Pharmacology RM147 Administration of Drugs and Other Therapeutic Agents
spellingShingle	QM Human anatomy QP Physiology RB Pathology RM Therapeutics. Pharmacology RM147 Administration of Drugs and Other Therapeutic Agents Al-Ani, Imad Matloub Dally Algantri, Khaleed R Abdel Wahab, Emad Mohamad Nafie Al-Mahmood, Sinan Mohammed Abdullah The nephrotoxicity of concurrent use of enalapril and gentamicin in rats
description	Objective: The present study was aimed to assess the concurrent administration of Enalapril (ENAL) and Gentamicin (GM) in the kidney of rats. Methods: Sixty male Sprague Dawley rats were divided into 4 main groups (n=15) according to the administered dose. Each main group was further subdivided into three subgroups according to the day of sacrificing (n=5). Group (C) was administered daily with normal saline as control, Group (E) was treated with oral ENAL, Group (G) was treated with 75 mg/kg GM, and Group (EG) was treated with GM and ENAL. The handling of the experiment persisted daily for 15 days, and the investigational examination carried out on days 5, 10, and 15. Results: The result showed that GM nephrotoxicity augmented with the period of the experimental study, there was rising in the levels of serum creatinine and blood urea nitrogen on the 10th day and persisted in rising significantly during the period on the 15th day of the experiment. Administration of ENAL showed no significant alteration from those of controls. While the concurrent administration of ENAL and GM showed that ENAL gradually increased GM nephrotoxicity, these physiological retrogressions were accompanied with intensive renal histopathological deteriorations. Conclusion: The present study has revealed that the concurrent administration of ENAL enormously aggravated the functional and histological nephrotoxicity of GM in rats.
format	Article
author	Al-Ani, Imad Matloub Dally Algantri, Khaleed R Abdel Wahab, Emad Mohamad Nafie Al-Mahmood, Sinan Mohammed Abdullah
author_facet	Al-Ani, Imad Matloub Dally Algantri, Khaleed R Abdel Wahab, Emad Mohamad Nafie Al-Mahmood, Sinan Mohammed Abdullah
author_sort	Al-Ani, Imad Matloub Dally
title	The nephrotoxicity of concurrent use of enalapril and gentamicin in rats
title_short	The nephrotoxicity of concurrent use of enalapril and gentamicin in rats
title_full	The nephrotoxicity of concurrent use of enalapril and gentamicin in rats
title_fullStr	The nephrotoxicity of concurrent use of enalapril and gentamicin in rats
title_full_unstemmed	The nephrotoxicity of concurrent use of enalapril and gentamicin in rats
title_sort	nephrotoxicity of concurrent use of enalapril and gentamicin in rats
publisher	Innovare Academic Sciences
publishDate	2018
url	http://irep.iium.edu.my/66221/ http://irep.iium.edu.my/66221/ http://irep.iium.edu.my/66221/ http://irep.iium.edu.my/66221/1/The%20nephrotoxicity%20of%20concurrent%20use%20of%20enalapril%20and%20gentamicin%20in%20rats.pdf http://irep.iium.edu.my/66221/7/66221_The%20nephrotoxicity%20of%20concurrent%20use%20of%20enalapril%20and%20gentamicin%20in%20rats_SCOPUS.pdf http://irep.iium.edu.my/66221/13/Scopus%20-%20Document%20details.pdf
first_indexed	2023-09-18T21:33:59Z
last_indexed	2023-09-18T21:33:59Z
_version_	1777412697641451520

The nephrotoxicity of concurrent use of enalapril and gentamicin in rats

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