Addressing formulation issues of syariah compliant generic sustained release antidiabetic solid dosage form.

Gliclazide (1-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea) is a second-generation sulfonylurea which is orally administered in the treatment of non-insulin-dependent diabetes mellitus in adults. Sustain release drugs help to improve drugs bioavailability by c...

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Bibliographic Details
Main Authors:	Mohd Nawi, Mohamed Sufian, Abul Bashar Mohammed, Helaluddin, Kasmuri, Abdul Razak, Tan, Soo Choon
Format:	Monograph
Language:	English
Published:	2018
Subjects:	RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry
Online Access:	http://irep.iium.edu.my/63437/ http://irep.iium.edu.my/63437/1/Research%20Completion%20Report%20RIGS%2015-090-0090_SUFIAN.pdf

id	iium-63437
recordtype	eprints
spelling	iium-634372018-05-05T16:31:14Z http://irep.iium.edu.my/63437/ Addressing formulation issues of syariah compliant generic sustained release antidiabetic solid dosage form. Mohd Nawi, Mohamed Sufian Abul Bashar Mohammed, Helaluddin Kasmuri, Abdul Razak Tan, Soo Choon RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry Gliclazide (1-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea) is a second-generation sulfonylurea which is orally administered in the treatment of non-insulin-dependent diabetes mellitus in adults. Sustain release drugs help to improve drugs bioavailability by controlling the time of drug release or prolonging it. We are reporting the formulations of 60 mg sustain release gliclazide tablets with careful choice of all the ingredients and processes related to syariah compliance manufacturing of pharmaceutical products. In this work, different ratios of xanthan gum, a natural gum and hydroxypropyl methylcellulose (HPMC) had been used as the release retardants to achieve the sustain release criteria. The tablets were produced by wet granulation and semi-automatic tableting process. All the formulations were evaluated for the thickness, hardness, friability, weight variation, content of active ingredient, and in vitro dissolution profile following the British Pharmacopoeia (BP) criteria. Tablet assay of active pharmaceutical ingredient (High Performance Liquid Chromatography [HPLC] method) was adopted from British Pharmacopoeia (BP) with some modification. The HPLC method validation covered the specificity, linearity, range, accuracy, precision, limit of detection (LOD), and limit of quantitation (LOQ). We expect that the outcome of our study could be useful for the formulation of such product that will be helpful for the Muslim patient especially during the fasting month. 2018 Monograph NonPeerReviewed application/pdf en http://irep.iium.edu.my/63437/1/Research%20Completion%20Report%20RIGS%2015-090-0090_SUFIAN.pdf Mohd Nawi, Mohamed Sufian and Abul Bashar Mohammed, Helaluddin and Kasmuri, Abdul Razak and Tan, Soo Choon (2018) Addressing formulation issues of syariah compliant generic sustained release antidiabetic solid dosage form. Project Report. UNSPECIFIED. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry
spellingShingle	RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry Mohd Nawi, Mohamed Sufian Abul Bashar Mohammed, Helaluddin Kasmuri, Abdul Razak Tan, Soo Choon Addressing formulation issues of syariah compliant generic sustained release antidiabetic solid dosage form.
description	Gliclazide (1-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea) is a second-generation sulfonylurea which is orally administered in the treatment of non-insulin-dependent diabetes mellitus in adults. Sustain release drugs help to improve drugs bioavailability by controlling the time of drug release or prolonging it. We are reporting the formulations of 60 mg sustain release gliclazide tablets with careful choice of all the ingredients and processes related to syariah compliance manufacturing of pharmaceutical products. In this work, different ratios of xanthan gum, a natural gum and hydroxypropyl methylcellulose (HPMC) had been used as the release retardants to achieve the sustain release criteria. The tablets were produced by wet granulation and semi-automatic tableting process. All the formulations were evaluated for the thickness, hardness, friability, weight variation, content of active ingredient, and in vitro dissolution profile following the British Pharmacopoeia (BP) criteria. Tablet assay of active pharmaceutical ingredient (High Performance Liquid Chromatography [HPLC] method) was adopted from British Pharmacopoeia (BP) with some modification. The HPLC method validation covered the specificity, linearity, range, accuracy, precision, limit of detection (LOD), and limit of quantitation (LOQ). We expect that the outcome of our study could be useful for the formulation of such product that will be helpful for the Muslim patient especially during the fasting month.
format	Monograph
author	Mohd Nawi, Mohamed Sufian Abul Bashar Mohammed, Helaluddin Kasmuri, Abdul Razak Tan, Soo Choon
author_facet	Mohd Nawi, Mohamed Sufian Abul Bashar Mohammed, Helaluddin Kasmuri, Abdul Razak Tan, Soo Choon
author_sort	Mohd Nawi, Mohamed Sufian
title	Addressing formulation issues of syariah compliant generic sustained release antidiabetic solid dosage form.
title_short	Addressing formulation issues of syariah compliant generic sustained release antidiabetic solid dosage form.
title_full	Addressing formulation issues of syariah compliant generic sustained release antidiabetic solid dosage form.
title_fullStr	Addressing formulation issues of syariah compliant generic sustained release antidiabetic solid dosage form.
title_full_unstemmed	Addressing formulation issues of syariah compliant generic sustained release antidiabetic solid dosage form.
title_sort	addressing formulation issues of syariah compliant generic sustained release antidiabetic solid dosage form.
publishDate	2018
url	http://irep.iium.edu.my/63437/ http://irep.iium.edu.my/63437/1/Research%20Completion%20Report%20RIGS%2015-090-0090_SUFIAN.pdf
first_indexed	2023-09-18T21:29:58Z
last_indexed	2023-09-18T21:29:58Z
_version_	1777412445197828096

Addressing formulation issues of syariah compliant generic sustained release antidiabetic solid dosage form.

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