Drug-drug interaction-related uncontrolled glycemia

Context: The literature of drug-drug interaction (DDI)-related uncontrolled causality, and preventability of DDI-induced UCG (HbA1c >7%) in outpatients glycemia (UCG) among outpatients with Type 2 diabetes mellitus is still limited. Aims: The aim of this study is to identify the prevalence, mecha...

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Main Authors: Hammad, Mohamed Anwar, Tangiisuran, Balamurugan, Kharshid, Abeer Mohamed, Abdul-Aziz, Noorizan, Hassan, Yahaya, Aziz, Nor Azizah, Elsayed, Tarek Mohamed Ali
Format: Article
Language:English
English
Published: Medknow Publications 2017
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http://irep.iium.edu.my/63015/1/63015_Drug-drug%20interaction-related%20uncontrolled%20glycemia_article.pdf
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spelling iium-630152018-04-18T07:40:13Z http://irep.iium.edu.my/63015/ Drug-drug interaction-related uncontrolled glycemia Hammad, Mohamed Anwar Tangiisuran, Balamurugan Kharshid, Abeer Mohamed Abdul-Aziz, Noorizan Hassan, Yahaya Aziz, Nor Azizah Elsayed, Tarek Mohamed Ali RS Pharmacy and materia medica Context: The literature of drug-drug interaction (DDI)-related uncontrolled causality, and preventability of DDI-induced UCG (HbA1c >7%) in outpatients glycemia (UCG) among outpatients with Type 2 diabetes mellitus is still limited. Aims: The aim of this study is to identify the prevalence, mechanism, severity, with Type 2 diabetes. Settings and Design: A cross-sectional study was conducted in Penang General Hospital. Methods: A computerized system for DDI checking was used to assess the severity and mechanism of DDIs. Drug interaction probability scale was used to evaluate the likelihood of DDIs. Preventability of DDIs has been determined by the instrument of Hallas. The UCG prevalence related to DDIs was further assessed. Statistical Analysis Used: SPSS 21.00 was used in this study. Results: From 425 outpatients with HbA1c% test, their mean age was 58.7 ± 12.8 years. Only 225 (52.9%) cases had controlled glycemia while 200 (47.1%) cases with UCG. They had multiple comorbidities, with a mean number of 3.8 ± 2.2/patient and often prescribed with multiple medications, with a mean number of 6.33 ± 4.67/patient. It has been detected that 86 DDIs causing UCG in 46 patients (23%) with range of (1-4) DDIs per patient. Drugs with DDI-induced UCG were as follows: diuretics (79%), salbutamol (9.2%), cortisones (5.8%), and others (6%). The majority of these DDIs were categorized as possible (77.9%) and preventable (37%). Conclusion: Nearly one-quarter of UCG was induced by DDIs; most of these DDIs are possible, and more than one-third are preventable. It was concluded that thiazide diuretics have the highest prevalence of DDI-related UCG. Medknow Publications 2017 Article PeerReviewed application/pdf en http://irep.iium.edu.my/63015/1/63015_Drug-drug%20interaction-related%20uncontrolled%20glycemia_article.pdf application/pdf en http://irep.iium.edu.my/63015/2/63015_Drug-drug%20interaction-related%20uncontrolled%20glycemia_scopus.pdf Hammad, Mohamed Anwar and Tangiisuran, Balamurugan and Kharshid, Abeer Mohamed and Abdul-Aziz, Noorizan and Hassan, Yahaya and Aziz, Nor Azizah and Elsayed, Tarek Mohamed Ali (2017) Drug-drug interaction-related uncontrolled glycemia. Journal of Pharmacy and Bioallied Sciences, 9 (4). pp. 221-228. ISSN 0976-4879 E-ISSN 0975-7406 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810071/ 10.4103/JPBS.JPBS_26_17
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
English
topic RS Pharmacy and materia medica
spellingShingle RS Pharmacy and materia medica
Hammad, Mohamed Anwar
Tangiisuran, Balamurugan
Kharshid, Abeer Mohamed
Abdul-Aziz, Noorizan
Hassan, Yahaya
Aziz, Nor Azizah
Elsayed, Tarek Mohamed Ali
Drug-drug interaction-related uncontrolled glycemia
description Context: The literature of drug-drug interaction (DDI)-related uncontrolled causality, and preventability of DDI-induced UCG (HbA1c >7%) in outpatients glycemia (UCG) among outpatients with Type 2 diabetes mellitus is still limited. Aims: The aim of this study is to identify the prevalence, mechanism, severity, with Type 2 diabetes. Settings and Design: A cross-sectional study was conducted in Penang General Hospital. Methods: A computerized system for DDI checking was used to assess the severity and mechanism of DDIs. Drug interaction probability scale was used to evaluate the likelihood of DDIs. Preventability of DDIs has been determined by the instrument of Hallas. The UCG prevalence related to DDIs was further assessed. Statistical Analysis Used: SPSS 21.00 was used in this study. Results: From 425 outpatients with HbA1c% test, their mean age was 58.7 ± 12.8 years. Only 225 (52.9%) cases had controlled glycemia while 200 (47.1%) cases with UCG. They had multiple comorbidities, with a mean number of 3.8 ± 2.2/patient and often prescribed with multiple medications, with a mean number of 6.33 ± 4.67/patient. It has been detected that 86 DDIs causing UCG in 46 patients (23%) with range of (1-4) DDIs per patient. Drugs with DDI-induced UCG were as follows: diuretics (79%), salbutamol (9.2%), cortisones (5.8%), and others (6%). The majority of these DDIs were categorized as possible (77.9%) and preventable (37%). Conclusion: Nearly one-quarter of UCG was induced by DDIs; most of these DDIs are possible, and more than one-third are preventable. It was concluded that thiazide diuretics have the highest prevalence of DDI-related UCG.
format Article
author Hammad, Mohamed Anwar
Tangiisuran, Balamurugan
Kharshid, Abeer Mohamed
Abdul-Aziz, Noorizan
Hassan, Yahaya
Aziz, Nor Azizah
Elsayed, Tarek Mohamed Ali
author_facet Hammad, Mohamed Anwar
Tangiisuran, Balamurugan
Kharshid, Abeer Mohamed
Abdul-Aziz, Noorizan
Hassan, Yahaya
Aziz, Nor Azizah
Elsayed, Tarek Mohamed Ali
author_sort Hammad, Mohamed Anwar
title Drug-drug interaction-related uncontrolled glycemia
title_short Drug-drug interaction-related uncontrolled glycemia
title_full Drug-drug interaction-related uncontrolled glycemia
title_fullStr Drug-drug interaction-related uncontrolled glycemia
title_full_unstemmed Drug-drug interaction-related uncontrolled glycemia
title_sort drug-drug interaction-related uncontrolled glycemia
publisher Medknow Publications
publishDate 2017
url http://irep.iium.edu.my/63015/
http://irep.iium.edu.my/63015/
http://irep.iium.edu.my/63015/
http://irep.iium.edu.my/63015/1/63015_Drug-drug%20interaction-related%20uncontrolled%20glycemia_article.pdf
http://irep.iium.edu.my/63015/2/63015_Drug-drug%20interaction-related%20uncontrolled%20glycemia_scopus.pdf
first_indexed 2023-09-18T21:29:20Z
last_indexed 2023-09-18T21:29:20Z
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