α-glucosidase inhibitors isolated from Mimosa pudica L.

The aim of the study was to isolate digestive enzymes inhibitors from Mimosa pudica through a bioassay-guided fractionation approach. Repeated silica gel and sephadex LH 20 column chromatographies of bioactive fractions afforded stigmasterol, quercetin and avicularin as digestive enzymes inhibitors...

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Main Authors:	Tasnuva, S. T., Ahmed, Qamar Uddin, Ghafoor, Kashif, Ferdosh, Sahena, Jahurul, M. H. A., Rukshana, A. H., Md. Jaffri, Juliana, Y. Al-Juhaimi, Fahad, Jalifah, L., Jalal, K. C. A., Ali, Md. Eaqub, Sarker, Md Zaidul Islam
Format:	Article
Language:	English English English
Published:	Taylor and Francis (UK) 2017
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/60959/ http://irep.iium.edu.my/60959/ http://irep.iium.edu.my/60959/ http://irep.iium.edu.my/60959/7/60959_%CE%B1-glucosidase%20inhibitors%20isolated%20from%20Mimosa%20pudica%20L_scopus.pdf http://irep.iium.edu.my/60959/13/Zaidul-2019.pdf http://irep.iium.edu.my/60959/19/Natural%20Product%20Research-2019-ISI.pdf

id	iium-60959
recordtype	eprints
spelling	iium-609592020-02-27T01:29:16Z http://irep.iium.edu.my/60959/ α-glucosidase inhibitors isolated from Mimosa pudica L. Tasnuva, S. T. Ahmed, Qamar Uddin Ghafoor, Kashif Ferdosh, Sahena Jahurul, M. H. A. Rukshana, A. H. Md. Jaffri, Juliana Y. Al-Juhaimi, Fahad Jalifah, L. Jalal, K. C. A. Ali, Md. Eaqub Sarker, Md Zaidul Islam QD Chemistry The aim of the study was to isolate digestive enzymes inhibitors from Mimosa pudica through a bioassay-guided fractionation approach. Repeated silica gel and sephadex LH 20 column chromatographies of bioactive fractions afforded stigmasterol, quercetin and avicularin as digestive enzymes inhibitors whose IC50 values as compared to acarbose (351.02 ± 1.46 μg mL−1) were found to be as 91.08 ± 1.54, 75.16 ± 0.92 and 481.7 ± 0.703 μg mL−1, respectively. In conclusion, M. pudica could be a good and safe source of digestive enzymes inhibitors for the management of diabetes in future. Taylor and Francis (UK) 2017-12-27 Article PeerReviewed application/pdf en http://irep.iium.edu.my/60959/7/60959_%CE%B1-glucosidase%20inhibitors%20isolated%20from%20Mimosa%20pudica%20L_scopus.pdf application/pdf en http://irep.iium.edu.my/60959/13/Zaidul-2019.pdf application/pdf en http://irep.iium.edu.my/60959/19/Natural%20Product%20Research-2019-ISI.pdf Tasnuva, S. T. and Ahmed, Qamar Uddin and Ghafoor, Kashif and Ferdosh, Sahena and Jahurul, M. H. A. and Rukshana, A. H. and Md. Jaffri, Juliana and Y. Al-Juhaimi, Fahad and Jalifah, L. and Jalal, K. C. A. and Ali, Md. Eaqub and Sarker, Md Zaidul Islam (2017) α-glucosidase inhibitors isolated from Mimosa pudica L. Natural Product Research, 33 (10). pp. 1495-1499. ISSN 1478-6427 http://www.tandfonline.com/doi/abs/10.1080/14786419.2017.1419224?journalCode=gnpl20 10.1080/14786419.2017.1419224
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	QD Chemistry
spellingShingle	QD Chemistry Tasnuva, S. T. Ahmed, Qamar Uddin Ghafoor, Kashif Ferdosh, Sahena Jahurul, M. H. A. Rukshana, A. H. Md. Jaffri, Juliana Y. Al-Juhaimi, Fahad Jalifah, L. Jalal, K. C. A. Ali, Md. Eaqub Sarker, Md Zaidul Islam α-glucosidase inhibitors isolated from Mimosa pudica L.
description	The aim of the study was to isolate digestive enzymes inhibitors from Mimosa pudica through a bioassay-guided fractionation approach. Repeated silica gel and sephadex LH 20 column chromatographies of bioactive fractions afforded stigmasterol, quercetin and avicularin as digestive enzymes inhibitors whose IC50 values as compared to acarbose (351.02 ± 1.46 μg mL−1) were found to be as 91.08 ± 1.54, 75.16 ± 0.92 and 481.7 ± 0.703 μg mL−1, respectively. In conclusion, M. pudica could be a good and safe source of digestive enzymes inhibitors for the management of diabetes in future.
format	Article
author	Tasnuva, S. T. Ahmed, Qamar Uddin Ghafoor, Kashif Ferdosh, Sahena Jahurul, M. H. A. Rukshana, A. H. Md. Jaffri, Juliana Y. Al-Juhaimi, Fahad Jalifah, L. Jalal, K. C. A. Ali, Md. Eaqub Sarker, Md Zaidul Islam
author_facet	Tasnuva, S. T. Ahmed, Qamar Uddin Ghafoor, Kashif Ferdosh, Sahena Jahurul, M. H. A. Rukshana, A. H. Md. Jaffri, Juliana Y. Al-Juhaimi, Fahad Jalifah, L. Jalal, K. C. A. Ali, Md. Eaqub Sarker, Md Zaidul Islam
author_sort	Tasnuva, S. T.
title	α-glucosidase inhibitors isolated from Mimosa pudica L.
title_short	α-glucosidase inhibitors isolated from Mimosa pudica L.
title_full	α-glucosidase inhibitors isolated from Mimosa pudica L.
title_fullStr	α-glucosidase inhibitors isolated from Mimosa pudica L.
title_full_unstemmed	α-glucosidase inhibitors isolated from Mimosa pudica L.
title_sort	α-glucosidase inhibitors isolated from mimosa pudica l.
publisher	Taylor and Francis (UK)
publishDate	2017
url	http://irep.iium.edu.my/60959/ http://irep.iium.edu.my/60959/ http://irep.iium.edu.my/60959/ http://irep.iium.edu.my/60959/7/60959_%CE%B1-glucosidase%20inhibitors%20isolated%20from%20Mimosa%20pudica%20L_scopus.pdf http://irep.iium.edu.my/60959/13/Zaidul-2019.pdf http://irep.iium.edu.my/60959/19/Natural%20Product%20Research-2019-ISI.pdf
first_indexed	2023-09-18T21:26:26Z
last_indexed	2023-09-18T21:26:26Z
_version_	1777412222987796480

α-glucosidase inhibitors isolated from Mimosa pudica L.

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