Prediction of clinical symptoms of schizophrenia based on COMT methylation marker

Introduction: The dopamine hypothesis of schizophrenia is based on the fact that hyper-dopaminergic state is involved in causing psychosis and antipsychotic drugs block the dopamine receptor. COMT regulates the homeostatic levels of neurotransmitter dopamine in the synapses and plays a role in the n...

Full description

Bibliographic Details
Main Authors: Abd. Rahim, Nour El Huda, Rahim, Mohd Nabil Fikri, Ku Zaifah, Norsidah, Mohd Noor, Hanisah, Abdullah, Kartini, A. Talib, Norlelawati
Format: Conference or Workshop Item
Language:English
English
Published: Kulliyyah of Medicine, International Islamic University Malaysia 2017
Subjects:
Online Access:http://irep.iium.edu.my/59599/
http://irep.iium.edu.my/59599/
http://irep.iium.edu.my/59599/1/Abstract%20ID2%20Poster%20MRS2017.pdf
http://irep.iium.edu.my/59599/2/HUDA%20MRS%20POSTER%201.pdf
id iium-59599
recordtype eprints
spelling iium-595992017-11-27T09:19:04Z http://irep.iium.edu.my/59599/ Prediction of clinical symptoms of schizophrenia based on COMT methylation marker Abd. Rahim, Nour El Huda Rahim, Mohd Nabil Fikri Ku Zaifah, Norsidah Mohd Noor, Hanisah Abdullah, Kartini A. Talib, Norlelawati RC Internal medicine RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Introduction: The dopamine hypothesis of schizophrenia is based on the fact that hyper-dopaminergic state is involved in causing psychosis and antipsychotic drugs block the dopamine receptor. COMT regulates the homeostatic levels of neurotransmitter dopamine in the synapses and plays a role in the neurocognitive function. The dysregulation of dopamine in the prefrontal cortex influences the cognitive function and the severity of the psychotic symptoms in schizophrenia. During epigenetic event, methylated COMT gene may cause reduction in its expression and thus contribute to the clinical presentation in schizophrenia. Therefore, the aim of this study was to assess the feasibility of using COMT DNA methylation for prediction of specific psychotic presentations of schizophrenia. Materials and method: In this study, 138 schizophrenia patients were recruited from the Psychiatry Clinic, Hospital Tengku Ampuan Afzan, Kuantan Pahang. Genomic DNA from the peripheral blood was subjected to the Methylight Taqman® analysis for quantitative measurement of the COMT DNA methylation. The psychopathological symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS). Results: The regression analysis showed that the Positive and Excited subdomains of PANSS were significant predictors of COMT hypomethylation (β= -0.288, p= -0.031; β= -0.288, p= -0.031). The Excited subdomain of PANSS was negatively correlated with COMT DNA methylation (r2= -0.380, p= 0.000) as well as the Depressed subdomain (r2= -0.288, p= 0.001). Conclusion: The relationship between the DNA methylation of COMT with the positive, excited and depressed symptoms might indicate the epigenetic role of COMT gene in the manifestation of schizophrenia. Kulliyyah of Medicine, International Islamic University Malaysia 2017-08-10 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/59599/1/Abstract%20ID2%20Poster%20MRS2017.pdf application/pdf en http://irep.iium.edu.my/59599/2/HUDA%20MRS%20POSTER%201.pdf Abd. Rahim, Nour El Huda and Rahim, Mohd Nabil Fikri and Ku Zaifah, Norsidah and Mohd Noor, Hanisah and Abdullah, Kartini and A. Talib, Norlelawati (2017) Prediction of clinical symptoms of schizophrenia based on COMT methylation marker. In: Medical Research Symposium 2017, 10th August 2017, Kuantan, Pahang. http://iiumedic.net/imjm/v1/download/Volume%2015%20Supplement/MRS2016-ABSTRACT-BOOK-86.pdf
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
English
topic RC Internal medicine
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
spellingShingle RC Internal medicine
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Abd. Rahim, Nour El Huda
Rahim, Mohd Nabil Fikri
Ku Zaifah, Norsidah
Mohd Noor, Hanisah
Abdullah, Kartini
A. Talib, Norlelawati
Prediction of clinical symptoms of schizophrenia based on COMT methylation marker
description Introduction: The dopamine hypothesis of schizophrenia is based on the fact that hyper-dopaminergic state is involved in causing psychosis and antipsychotic drugs block the dopamine receptor. COMT regulates the homeostatic levels of neurotransmitter dopamine in the synapses and plays a role in the neurocognitive function. The dysregulation of dopamine in the prefrontal cortex influences the cognitive function and the severity of the psychotic symptoms in schizophrenia. During epigenetic event, methylated COMT gene may cause reduction in its expression and thus contribute to the clinical presentation in schizophrenia. Therefore, the aim of this study was to assess the feasibility of using COMT DNA methylation for prediction of specific psychotic presentations of schizophrenia. Materials and method: In this study, 138 schizophrenia patients were recruited from the Psychiatry Clinic, Hospital Tengku Ampuan Afzan, Kuantan Pahang. Genomic DNA from the peripheral blood was subjected to the Methylight Taqman® analysis for quantitative measurement of the COMT DNA methylation. The psychopathological symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS). Results: The regression analysis showed that the Positive and Excited subdomains of PANSS were significant predictors of COMT hypomethylation (β= -0.288, p= -0.031; β= -0.288, p= -0.031). The Excited subdomain of PANSS was negatively correlated with COMT DNA methylation (r2= -0.380, p= 0.000) as well as the Depressed subdomain (r2= -0.288, p= 0.001). Conclusion: The relationship between the DNA methylation of COMT with the positive, excited and depressed symptoms might indicate the epigenetic role of COMT gene in the manifestation of schizophrenia.
format Conference or Workshop Item
author Abd. Rahim, Nour El Huda
Rahim, Mohd Nabil Fikri
Ku Zaifah, Norsidah
Mohd Noor, Hanisah
Abdullah, Kartini
A. Talib, Norlelawati
author_facet Abd. Rahim, Nour El Huda
Rahim, Mohd Nabil Fikri
Ku Zaifah, Norsidah
Mohd Noor, Hanisah
Abdullah, Kartini
A. Talib, Norlelawati
author_sort Abd. Rahim, Nour El Huda
title Prediction of clinical symptoms of schizophrenia based on COMT methylation marker
title_short Prediction of clinical symptoms of schizophrenia based on COMT methylation marker
title_full Prediction of clinical symptoms of schizophrenia based on COMT methylation marker
title_fullStr Prediction of clinical symptoms of schizophrenia based on COMT methylation marker
title_full_unstemmed Prediction of clinical symptoms of schizophrenia based on COMT methylation marker
title_sort prediction of clinical symptoms of schizophrenia based on comt methylation marker
publisher Kulliyyah of Medicine, International Islamic University Malaysia
publishDate 2017
url http://irep.iium.edu.my/59599/
http://irep.iium.edu.my/59599/
http://irep.iium.edu.my/59599/1/Abstract%20ID2%20Poster%20MRS2017.pdf
http://irep.iium.edu.my/59599/2/HUDA%20MRS%20POSTER%201.pdf
first_indexed 2023-09-18T21:24:27Z
last_indexed 2023-09-18T21:24:27Z
_version_ 1777412097633681408