Methylation-specific PCR Revealed Aberrant Promoter Gene Methylation of p16, MGMT and SPOCK2 in Diffuse Large B-cell Lymphoma

DNA methylation silences the gene through addition of methyl group. p16, a tumor suppressor gene that inhibits cyclin-dependent kinase, inactivates the Rb protein and blocks G1 phase in a normal cell cycle. A DNA repair gene, MGMT removes alkyl adduct to a cysteine residue within the protein...

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Bibliographic Details
Main Authors: Mohd. Ridah, Lailatul Jalilah, Zainuddin, Norafiza, A. Talib, Norlelawati, Hussain, Faezahtul Arbaeyah
Format: Conference or Workshop Item
Language:English
Published: 2015
Subjects:
Online Access:http://irep.iium.edu.my/54383/
http://irep.iium.edu.my/54383/1/ICBHSR.pdf