A study of binding serum albumin proteins with β-carboline alkaloids :Critical for pharmacological action of various drugs

β-Carboline alkaloids present in Peganum harmala L. (harmal) have recently drawn attention due to their antitumor activities. Bovine Serum Albumin (BSA) is the major soluble protein constituent of the circulatory system, and has many physiological functions including the transportation of various...

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Main Authors:	Qadir, Anmbiya, Khuroo, Mohammad Akbar, Akbar, Iqrah, Jamal, Parveen
Format:	Conference or Workshop Item
Language:	English
Published:	Kulliyah of Engineering, International Islamic University Malaysia 2016
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/51789/ http://irep.iium.edu.my/51789/ http://irep.iium.edu.my/51789/1/51789.pdf

id	iium-51789
recordtype	eprints
spelling	iium-517892017-10-19T13:37:35Z http://irep.iium.edu.my/51789/ A study of binding serum albumin proteins with β-carboline alkaloids :Critical for pharmacological action of various drugs Qadir, Anmbiya Khuroo, Mohammad Akbar Akbar, Iqrah Jamal, Parveen QD Chemistry β-Carboline alkaloids present in Peganum harmala L. (harmal) have recently drawn attention due to their antitumor activities. Bovine Serum Albumin (BSA) is the major soluble protein constituent of the circulatory system, and has many physiological functions including the transportation of various compounds as ligands. In this study the binding of β-carboline alkaloids to Bovine Serum Albumin (BSA) has been investigated by using a constant protein concentration and varying drug concentrations. The binding modes of β-carboline alkaloids were analyzed by using FTIR and UV–Vis spectroscopic methods. Spectroscopic evidence showed that β-carboline alkaloids bind BSA via hydrophobic interaction and Vander Waals contacts along with Hbonding with the–NH groups. Kulliyah of Engineering, International Islamic University Malaysia 2016 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/51789/1/51789.pdf Qadir, Anmbiya and Khuroo, Mohammad Akbar and Akbar, Iqrah and Jamal, Parveen (2016) A study of binding serum albumin proteins with β-carboline alkaloids :Critical for pharmacological action of various drugs. In: 4th International Conference on Biotechnology Engineering 2016 (ICBioE 2016), 25th-27th July 2016, Kuala Lumpur. http://www.iium.edu.my/icbioe/2016/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QD Chemistry
spellingShingle	QD Chemistry Qadir, Anmbiya Khuroo, Mohammad Akbar Akbar, Iqrah Jamal, Parveen A study of binding serum albumin proteins with β-carboline alkaloids :Critical for pharmacological action of various drugs
description	β-Carboline alkaloids present in Peganum harmala L. (harmal) have recently drawn attention due to their antitumor activities. Bovine Serum Albumin (BSA) is the major soluble protein constituent of the circulatory system, and has many physiological functions including the transportation of various compounds as ligands. In this study the binding of β-carboline alkaloids to Bovine Serum Albumin (BSA) has been investigated by using a constant protein concentration and varying drug concentrations. The binding modes of β-carboline alkaloids were analyzed by using FTIR and UV–Vis spectroscopic methods. Spectroscopic evidence showed that β-carboline alkaloids bind BSA via hydrophobic interaction and Vander Waals contacts along with Hbonding with the–NH groups.
format	Conference or Workshop Item
author	Qadir, Anmbiya Khuroo, Mohammad Akbar Akbar, Iqrah Jamal, Parveen
author_facet	Qadir, Anmbiya Khuroo, Mohammad Akbar Akbar, Iqrah Jamal, Parveen
author_sort	Qadir, Anmbiya
title	A study of binding serum albumin proteins with β-carboline alkaloids :Critical for pharmacological action of various drugs
title_short	A study of binding serum albumin proteins with β-carboline alkaloids :Critical for pharmacological action of various drugs
title_full	A study of binding serum albumin proteins with β-carboline alkaloids :Critical for pharmacological action of various drugs
title_fullStr	A study of binding serum albumin proteins with β-carboline alkaloids :Critical for pharmacological action of various drugs
title_full_unstemmed	A study of binding serum albumin proteins with β-carboline alkaloids :Critical for pharmacological action of various drugs
title_sort	study of binding serum albumin proteins with β-carboline alkaloids :critical for pharmacological action of various drugs
publisher	Kulliyah of Engineering, International Islamic University Malaysia
publishDate	2016
url	http://irep.iium.edu.my/51789/ http://irep.iium.edu.my/51789/ http://irep.iium.edu.my/51789/1/51789.pdf
first_indexed	2023-09-18T21:13:25Z
last_indexed	2023-09-18T21:13:25Z
_version_	1777411403674550272

A study of binding serum albumin proteins with β-carboline alkaloids :Critical for pharmacological action of various drugs

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