Induction of apoptosis and oxidative stress in estrogen receptor-negative breast cancer, MDA-MB231 cells, by ethanolic mango seed extract

In this study, the effect of mango kernel extract in the induction of apoptosis of the breast cancer (MDA-MB-231) cell line was examined. This is an attempt to discover alternatives to current therapeutic regimes in the treatment of breast cancers. Methods: The pro-apoptotic markers, Bax, cytochrome...

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Main Authors:	Hussah Abdullah, Al-Shwyeh, Sabo Mohammed, Abdulkarim, Rasedee, Abdullah, Mirghani, Mohamed Elwathig Saeed, Al-Qubaisi, Mothanna Sadiq
Format:	Article
Language:	English English
Published:	BioMed Central 2015
Subjects:	Q Science (General)
Online Access:	http://irep.iium.edu.my/48564/ http://irep.iium.edu.my/48564/ http://irep.iium.edu.my/48564/ http://irep.iium.edu.my/48564/1/Mango_%28B_cancer%29_12906_2015_BMC.pdf http://irep.iium.edu.my/48564/4/48564_wos-scopus.pdf

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recordtype	eprints
spelling	iium-485642017-11-23T07:51:46Z http://irep.iium.edu.my/48564/ Induction of apoptosis and oxidative stress in estrogen receptor-negative breast cancer, MDA-MB231 cells, by ethanolic mango seed extract Hussah Abdullah, Al-Shwyeh Sabo Mohammed, Abdulkarim Rasedee, Abdullah Mirghani, Mohamed Elwathig Saeed Al-Qubaisi, Mothanna Sadiq Q Science (General) In this study, the effect of mango kernel extract in the induction of apoptosis of the breast cancer (MDA-MB-231) cell line was examined. This is an attempt to discover alternatives to current therapeutic regimes in the treatment of breast cancers. Methods: The pro-apoptotic markers, Bax, cytochrome c, caspases-. -8 and -9, and anti-apoptotic markers, Bcl-2, p53 and glutathione were determined in MDA-MB231 cells treated for 12 and 24h with mango kernel extract. Results: The results showed that the extract produced a time- and dose-dependent increases in pro-apoptotic proteins and oxidative stress markers with a corresponding decrease in anti-apoptotic markers. Conclusions: Based on the findings, mango kernel extract modulates redox balance in MDA-MB-231 breast cancer cells with a tendency for apoptotic cell death. The changes observed in this study may collectively underlie the basis for the cell death induced in MDA-MB-231 breast cancer cells by mango kernel extract. Thus, mango kernel extract has potential to be developed into an antibreast cancer mixture, and hence these results are worth studying further. BioMed Central 2015 Article PeerReviewed application/pdf en http://irep.iium.edu.my/48564/1/Mango_%28B_cancer%29_12906_2015_BMC.pdf application/pdf en http://irep.iium.edu.my/48564/4/48564_wos-scopus.pdf Hussah Abdullah, Al-Shwyeh and Sabo Mohammed, Abdulkarim and Rasedee, Abdullah and Mirghani, Mohamed Elwathig Saeed and Al-Qubaisi, Mothanna Sadiq (2015) Induction of apoptosis and oxidative stress in estrogen receptor-negative breast cancer, MDA-MB231 cells, by ethanolic mango seed extract. BMC Complementary and Alternative Medicine, 15 (45). pp. 1-7. ISSN 1472-6882 http://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-015-0575-x DOI 10.1186/s12906-015-0575-x
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	Q Science (General)
spellingShingle	Q Science (General) Hussah Abdullah, Al-Shwyeh Sabo Mohammed, Abdulkarim Rasedee, Abdullah Mirghani, Mohamed Elwathig Saeed Al-Qubaisi, Mothanna Sadiq Induction of apoptosis and oxidative stress in estrogen receptor-negative breast cancer, MDA-MB231 cells, by ethanolic mango seed extract
description	In this study, the effect of mango kernel extract in the induction of apoptosis of the breast cancer (MDA-MB-231) cell line was examined. This is an attempt to discover alternatives to current therapeutic regimes in the treatment of breast cancers. Methods: The pro-apoptotic markers, Bax, cytochrome c, caspases-. -8 and -9, and anti-apoptotic markers, Bcl-2, p53 and glutathione were determined in MDA-MB231 cells treated for 12 and 24h with mango kernel extract. Results: The results showed that the extract produced a time- and dose-dependent increases in pro-apoptotic proteins and oxidative stress markers with a corresponding decrease in anti-apoptotic markers. Conclusions: Based on the findings, mango kernel extract modulates redox balance in MDA-MB-231 breast cancer cells with a tendency for apoptotic cell death. The changes observed in this study may collectively underlie the basis for the cell death induced in MDA-MB-231 breast cancer cells by mango kernel extract. Thus, mango kernel extract has potential to be developed into an antibreast cancer mixture, and hence these results are worth studying further.
format	Article
author	Hussah Abdullah, Al-Shwyeh Sabo Mohammed, Abdulkarim Rasedee, Abdullah Mirghani, Mohamed Elwathig Saeed Al-Qubaisi, Mothanna Sadiq
author_facet	Hussah Abdullah, Al-Shwyeh Sabo Mohammed, Abdulkarim Rasedee, Abdullah Mirghani, Mohamed Elwathig Saeed Al-Qubaisi, Mothanna Sadiq
author_sort	Hussah Abdullah, Al-Shwyeh
title	Induction of apoptosis and oxidative stress in estrogen receptor-negative breast cancer, MDA-MB231 cells, by ethanolic mango seed extract
title_short	Induction of apoptosis and oxidative stress in estrogen receptor-negative breast cancer, MDA-MB231 cells, by ethanolic mango seed extract
title_full	Induction of apoptosis and oxidative stress in estrogen receptor-negative breast cancer, MDA-MB231 cells, by ethanolic mango seed extract
title_fullStr	Induction of apoptosis and oxidative stress in estrogen receptor-negative breast cancer, MDA-MB231 cells, by ethanolic mango seed extract
title_full_unstemmed	Induction of apoptosis and oxidative stress in estrogen receptor-negative breast cancer, MDA-MB231 cells, by ethanolic mango seed extract
title_sort	induction of apoptosis and oxidative stress in estrogen receptor-negative breast cancer, mda-mb231 cells, by ethanolic mango seed extract
publisher	BioMed Central
publishDate	2015
url	http://irep.iium.edu.my/48564/ http://irep.iium.edu.my/48564/ http://irep.iium.edu.my/48564/ http://irep.iium.edu.my/48564/1/Mango_%28B_cancer%29_12906_2015_BMC.pdf http://irep.iium.edu.my/48564/4/48564_wos-scopus.pdf
first_indexed	2023-09-18T21:08:51Z
last_indexed	2023-09-18T21:08:51Z
_version_	1777411117035814912

Induction of apoptosis and oxidative stress in estrogen receptor-negative breast cancer, MDA-MB231 cells, by ethanolic mango seed extract

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