Ion-selective electrode biochip for applications in a liquid environment

Physiological sensing conducted in a liquid environment requires electrodes with long lifetime. The development of a robust ion-selective electrode–based biochip in a lab-on-a-chip platform is described. To compare electrode lifetime, which is driven by the transducer layer, electrochemical measurem...

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Main Authors:	Wan Salim, Wan Wardatul Amani, Hermann, Andrew C., Zietchek, Michael Z., Pfluger, Jonathan P., Park, Joon H., ul Haque, Aeraj, Sanober, Fahmi, Porterfield, Marshall D.
Other Authors:	Ibrahim, Fatimah
Format:	Conference or Workshop Item
Language:	English English
Published:	Springer 2016
Subjects:	T Technology (General)
Online Access:	http://irep.iium.edu.my/47221/ http://irep.iium.edu.my/47221/ http://irep.iium.edu.my/47221/ http://irep.iium.edu.my/47221/7/47221_Ion-selective%20electrode%20biochip%20for%20applications_SCOPUS.pdf http://irep.iium.edu.my/47221/13/47221_Ion-selective%20electrode%20biochip%20for%20applications%20in%20a%20liquid%20environment.pdf

id	iium-47221
recordtype	eprints
spelling	iium-472212017-10-20T04:10:54Z http://irep.iium.edu.my/47221/ Ion-selective electrode biochip for applications in a liquid environment Wan Salim, Wan Wardatul Amani Hermann, Andrew C. Zietchek, Michael Z. Pfluger, Jonathan P. Park, Joon H. ul Haque, Aeraj Sanober, Fahmi Porterfield, Marshall D. T Technology (General) Physiological sensing conducted in a liquid environment requires electrodes with long lifetime. The development of a robust ion-selective electrode–based biochip in a lab-on-a-chip platform is described. To compare electrode lifetime, which is driven by the transducer layer, electrochemical measurements were performed in a custom-made flow-cell chamber. The results of potentiometric measurement of cationic analytes demonstrate the electrodes to have a near-Nernstian slope profile even after they are stored for almost a month in liquid medium. The electrodes also achieved H2O2 amperometric sensitivity (1.25 and 3.32 µAmM-1cm-2 for PEDOT:PSS and PEDOT:CaSO4 respectively) and lower detection limit (2.21 µM, 8.4 µM, 3.44 µM, for H+, NH4+, Ca2+ respectively) comparable to that of wire-type electrodes. Furthermore, the lifetime is dependent on the electrodeposition method of the conductive polymer, and the transducer layer must be modified to fit the analyte types. These results indicate that extended lifetime of microfabricated ion-selective electrodes in a multiplex format can be realized by optimizing the microfabricated electrode surface functionalization. Springer Ibrahim, Fatimah Usman, Juliana Mohktar, Mas Sahidayana Ahmad, Mohd Yazed 2016 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/47221/7/47221_Ion-selective%20electrode%20biochip%20for%20applications_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/47221/13/47221_Ion-selective%20electrode%20biochip%20for%20applications%20in%20a%20liquid%20environment.pdf Wan Salim, Wan Wardatul Amani and Hermann, Andrew C. and Zietchek, Michael Z. and Pfluger, Jonathan P. and Park, Joon H. and ul Haque, Aeraj and Sanober, Fahmi and Porterfield, Marshall D. (2016) Ion-selective electrode biochip for applications in a liquid environment. In: International Conference for Innovation in Biomedical Engineering and Life Sciences (ICIBEL2015), 6 - 8 December 2015, Putrajaya, Malaysia. http://www.springer.com/series/7403 10.1007/978-981-10-0266-3_18
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	T Technology (General)
spellingShingle	T Technology (General) Wan Salim, Wan Wardatul Amani Hermann, Andrew C. Zietchek, Michael Z. Pfluger, Jonathan P. Park, Joon H. ul Haque, Aeraj Sanober, Fahmi Porterfield, Marshall D. Ion-selective electrode biochip for applications in a liquid environment
description	Physiological sensing conducted in a liquid environment requires electrodes with long lifetime. The development of a robust ion-selective electrode–based biochip in a lab-on-a-chip platform is described. To compare electrode lifetime, which is driven by the transducer layer, electrochemical measurements were performed in a custom-made flow-cell chamber. The results of potentiometric measurement of cationic analytes demonstrate the electrodes to have a near-Nernstian slope profile even after they are stored for almost a month in liquid medium. The electrodes also achieved H2O2 amperometric sensitivity (1.25 and 3.32 µAmM-1cm-2 for PEDOT:PSS and PEDOT:CaSO4 respectively) and lower detection limit (2.21 µM, 8.4 µM, 3.44 µM, for H+, NH4+, Ca2+ respectively) comparable to that of wire-type electrodes. Furthermore, the lifetime is dependent on the electrodeposition method of the conductive polymer, and the transducer layer must be modified to fit the analyte types. These results indicate that extended lifetime of microfabricated ion-selective electrodes in a multiplex format can be realized by optimizing the microfabricated electrode surface functionalization.
author2	Ibrahim, Fatimah
author_facet	Ibrahim, Fatimah Wan Salim, Wan Wardatul Amani Hermann, Andrew C. Zietchek, Michael Z. Pfluger, Jonathan P. Park, Joon H. ul Haque, Aeraj Sanober, Fahmi Porterfield, Marshall D.
format	Conference or Workshop Item
author	Wan Salim, Wan Wardatul Amani Hermann, Andrew C. Zietchek, Michael Z. Pfluger, Jonathan P. Park, Joon H. ul Haque, Aeraj Sanober, Fahmi Porterfield, Marshall D.
author_sort	Wan Salim, Wan Wardatul Amani
title	Ion-selective electrode biochip for applications in a liquid environment
title_short	Ion-selective electrode biochip for applications in a liquid environment
title_full	Ion-selective electrode biochip for applications in a liquid environment
title_fullStr	Ion-selective electrode biochip for applications in a liquid environment
title_full_unstemmed	Ion-selective electrode biochip for applications in a liquid environment
title_sort	ion-selective electrode biochip for applications in a liquid environment
publisher	Springer
publishDate	2016
url	http://irep.iium.edu.my/47221/ http://irep.iium.edu.my/47221/ http://irep.iium.edu.my/47221/ http://irep.iium.edu.my/47221/7/47221_Ion-selective%20electrode%20biochip%20for%20applications_SCOPUS.pdf http://irep.iium.edu.my/47221/13/47221_Ion-selective%20electrode%20biochip%20for%20applications%20in%20a%20liquid%20environment.pdf
first_indexed	2023-09-18T21:07:12Z
last_indexed	2023-09-18T21:07:12Z
_version_	1777411012946821120

Ion-selective electrode biochip for applications in a liquid environment

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