Screening of various parts of phaleria macrocarpa plant for α-glucosidase inhibitory activity

Phaleria macrocarpa is an herbal plant used in Malaysia to enhance vitality. The aim of this study was to screen the α -glucosidase inhibitory activity of different parts (fruit flesh, leaves and stem) of P. macrocarpa . Methanol (polar) and n-hexane (nonpolar) extracts, obtained by room tempera...

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Main Authors:	Evan Prince, Sabina, Sarker, Md. Zaidul Islam, Ghafoor, Kashif, Md. Jaffri, Juliana, Ferdosh, Sahena, Elfadıl Elfadl, Babiker, Perumal, Vikneswari, Hamed, Mohamed Bey Baba, Amid, Mehrnoush, Khatib, Alfi
Format:	Article
Language:	English English English
Published:	Wiley-Blackwell 2016
Subjects:	Q Science (General) T Technology (General)
Online Access:	http://irep.iium.edu.my/46843/ http://irep.iium.edu.my/46843/ http://irep.iium.edu.my/46843/ http://irep.iium.edu.my/46843/1/46843_Screening%20of%20various%20parts%20of%20phaleria%20macrocarpa.pdf http://irep.iium.edu.my/46843/2/46843_Screening%20of%20various%20parts%20of%20phaleria%20macrocarpa_WOS.pdf http://irep.iium.edu.my/46843/3/46843_Screening%20of%20various%20parts%20of%20phaleria%20macrocarpa_SCOPUS.pdf

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recordtype	eprints
spelling	iium-468432017-02-13T03:07:32Z http://irep.iium.edu.my/46843/ Screening of various parts of phaleria macrocarpa plant for α-glucosidase inhibitory activity Evan Prince, Sabina Sarker, Md. Zaidul Islam Ghafoor, Kashif Md. Jaffri, Juliana Ferdosh, Sahena Elfadıl Elfadl, Babiker Perumal, Vikneswari Hamed, Mohamed Bey Baba Amid, Mehrnoush Khatib, Alfi Q Science (General) T Technology (General) Phaleria macrocarpa is an herbal plant used in Malaysia to enhance vitality. The aim of this study was to screen the α -glucosidase inhibitory activity of different parts (fruit flesh, leaves and stem) of P. macrocarpa . Methanol (polar) and n-hexane (nonpolar) extracts, obtained by room temperature solvent extraction, were evaluated for in vitro α-glucosidase activity inhibition. The compounds were identified by using gas chromatography-mass spectrometry (GC-MS) according to their similarity index of >70%, which might be responsible for α-glucosidase inhibitory activity. The methanol extract of the fruit flesh had the highest yield (25.6±0.5%), whereas the n-hexane extract of the stem is more effective against α-glucosidase activity (IC500.8±0.1μg/mL). The fruit flesh (IC501.3±0.2μg/mL)and leaves (IC501.6±0.6μg/mL) had also well effectively. The identified metabo-lites are predominantly phenolics, carbohydrates, triterpenes and organic acids,such as D-fructose, squalene,α -linolenic acid and α-D-glucopyranoside. In-depth chemical profiling using GC-MS was performed for the first time for this plant to assess the likely compounds present in the extract that could be associated with anti-hyperglycemic activity. Of the three parts tested, every part indicates the potential α-glucosidase inhibitory activity and hexane extract of stem showed more inhibitory activity among all extracts. Thus,P. macrocarpa can attenuate hyperglycemia by potently inhibiting carbohydrate hydrolyzing enzymes, making it a viable plant as a source of natural compounds for the management of type 2 diabetes mellitus. Wiley-Blackwell 2016-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/46843/1/46843_Screening%20of%20various%20parts%20of%20phaleria%20macrocarpa.pdf application/pdf en http://irep.iium.edu.my/46843/2/46843_Screening%20of%20various%20parts%20of%20phaleria%20macrocarpa_WOS.pdf application/pdf en http://irep.iium.edu.my/46843/3/46843_Screening%20of%20various%20parts%20of%20phaleria%20macrocarpa_SCOPUS.pdf Evan Prince, Sabina and Sarker, Md. Zaidul Islam and Ghafoor, Kashif and Md. Jaffri, Juliana and Ferdosh, Sahena and Elfadıl Elfadl, Babiker and Perumal, Vikneswari and Hamed, Mohamed Bey Baba and Amid, Mehrnoush and Khatib, Alfi (2016) Screening of various parts of phaleria macrocarpa plant for α-glucosidase inhibitory activity. Journal of Food Biochemistry, 40 (2). pp. 201-210. ISSN 1745-4514 http://onlinelibrary.wiley.com/wol1/doi/10.1111/jfbc.12212/abstract 10.1111/jfbc.12212
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	Q Science (General) T Technology (General)
spellingShingle	Q Science (General) T Technology (General) Evan Prince, Sabina Sarker, Md. Zaidul Islam Ghafoor, Kashif Md. Jaffri, Juliana Ferdosh, Sahena Elfadıl Elfadl, Babiker Perumal, Vikneswari Hamed, Mohamed Bey Baba Amid, Mehrnoush Khatib, Alfi Screening of various parts of phaleria macrocarpa plant for α-glucosidase inhibitory activity
description	Phaleria macrocarpa is an herbal plant used in Malaysia to enhance vitality. The aim of this study was to screen the α -glucosidase inhibitory activity of different parts (fruit flesh, leaves and stem) of P. macrocarpa . Methanol (polar) and n-hexane (nonpolar) extracts, obtained by room temperature solvent extraction, were evaluated for in vitro α-glucosidase activity inhibition. The compounds were identified by using gas chromatography-mass spectrometry (GC-MS) according to their similarity index of >70%, which might be responsible for α-glucosidase inhibitory activity. The methanol extract of the fruit flesh had the highest yield (25.6±0.5%), whereas the n-hexane extract of the stem is more effective against α-glucosidase activity (IC500.8±0.1μg/mL). The fruit flesh (IC501.3±0.2μg/mL)and leaves (IC501.6±0.6μg/mL) had also well effectively. The identified metabo-lites are predominantly phenolics, carbohydrates, triterpenes and organic acids,such as D-fructose, squalene,α -linolenic acid and α-D-glucopyranoside. In-depth chemical profiling using GC-MS was performed for the first time for this plant to assess the likely compounds present in the extract that could be associated with anti-hyperglycemic activity. Of the three parts tested, every part indicates the potential α-glucosidase inhibitory activity and hexane extract of stem showed more inhibitory activity among all extracts. Thus,P. macrocarpa can attenuate hyperglycemia by potently inhibiting carbohydrate hydrolyzing enzymes, making it a viable plant as a source of natural compounds for the management of type 2 diabetes mellitus.
format	Article
author	Evan Prince, Sabina Sarker, Md. Zaidul Islam Ghafoor, Kashif Md. Jaffri, Juliana Ferdosh, Sahena Elfadıl Elfadl, Babiker Perumal, Vikneswari Hamed, Mohamed Bey Baba Amid, Mehrnoush Khatib, Alfi
author_facet	Evan Prince, Sabina Sarker, Md. Zaidul Islam Ghafoor, Kashif Md. Jaffri, Juliana Ferdosh, Sahena Elfadıl Elfadl, Babiker Perumal, Vikneswari Hamed, Mohamed Bey Baba Amid, Mehrnoush Khatib, Alfi
author_sort	Evan Prince, Sabina
title	Screening of various parts of phaleria macrocarpa plant for α-glucosidase inhibitory activity
title_short	Screening of various parts of phaleria macrocarpa plant for α-glucosidase inhibitory activity
title_full	Screening of various parts of phaleria macrocarpa plant for α-glucosidase inhibitory activity
title_fullStr	Screening of various parts of phaleria macrocarpa plant for α-glucosidase inhibitory activity
title_full_unstemmed	Screening of various parts of phaleria macrocarpa plant for α-glucosidase inhibitory activity
title_sort	screening of various parts of phaleria macrocarpa plant for α-glucosidase inhibitory activity
publisher	Wiley-Blackwell
publishDate	2016
url	http://irep.iium.edu.my/46843/ http://irep.iium.edu.my/46843/ http://irep.iium.edu.my/46843/ http://irep.iium.edu.my/46843/1/46843_Screening%20of%20various%20parts%20of%20phaleria%20macrocarpa.pdf http://irep.iium.edu.my/46843/2/46843_Screening%20of%20various%20parts%20of%20phaleria%20macrocarpa_WOS.pdf http://irep.iium.edu.my/46843/3/46843_Screening%20of%20various%20parts%20of%20phaleria%20macrocarpa_SCOPUS.pdf
first_indexed	2023-09-18T21:06:40Z
last_indexed	2023-09-18T21:06:40Z
_version_	1777410978914238464

Screening of various parts of phaleria macrocarpa plant for α-glucosidase inhibitory activity

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