Long-term consumption effect of eurycoma longifolia jack on histopathological changes in the vital organs in rats

Introduction:The use of Eurycoma longifolia Jack (ELJ)has increased in Southeast Asia especially Malaysia where it is widely used as power enhancement agent. Its use has become nationwide in Malaysia and Indonesia in daily life as beverage to enhance energy and stamina especially among males. Howev...

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Main Author:	Alfaqeh, Hamoud Hussein Mohammed
Format:	Conference or Workshop Item
Language:	English
Published:	AENSI Journals 2014
Subjects:	QP Physiology RB Pathology
Online Access:	http://irep.iium.edu.my/44056/ http://irep.iium.edu.my/44056/ http://irep.iium.edu.my/44056/1/ICACB-5th-6th__Dec_2014-_Bandung-_Indonesia.pdf

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spelling	iium-440562018-05-23T05:37:31Z http://irep.iium.edu.my/44056/ Long-term consumption effect of eurycoma longifolia jack on histopathological changes in the vital organs in rats Alfaqeh, Hamoud Hussein Mohammed QP Physiology RB Pathology Introduction:The use of Eurycoma longifolia Jack (ELJ)has increased in Southeast Asia especially Malaysia where it is widely used as power enhancement agent. Its use has become nationwide in Malaysia and Indonesia in daily life as beverage to enhance energy and stamina especially among males. However, its effect on the safety of vital organs of the body has not been studied properly.Thus, the main objective of this study was to determine whether long-term use of ELJ has side effects on the vital organs such as Pancreas,Liver and Kidney in rats. Materials and methods: Three different concentrations of aqueous extract of ELJ were prepared and dissolved in distilled water. A total of 32 Sprague-Dawley male rats were used and randomly divided into three test groups and control. The test groups were given different doses (low dose 250 mg/kg bw, medium dose 500mg/kg bw and high dose 1000 mg/kg bw) of aqueous extract of ELJ,respectively. Control group was given distilled water alone. Doses were given orally and daily for 5 weeks. After 5 weeks,animals were sacrificed; whole liver tissues were obtained, fixed in 10 percent formaldehyde overnight for histological examination. Result: Histological observations showed mild to moderate degrees of hemorrhage,hepatocytes degeneration and severe fatty changes in liver tissue of the test groups treated with ELJ as compared to control. Conclusion: In conclusion, the long-term daily consumption of ELJ in large quantity as beverage may cause fatty changes, hemorrhage and hepatocytes degeneration in the liver tissue. The Pancreatic tissues on the three groups treated with different concentration doses do not show any necrosis or inflammation in the treated groups. AENSI Journals 2014-12-06 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/44056/1/ICACB-5th-6th__Dec_2014-_Bandung-_Indonesia.pdf Alfaqeh, Hamoud Hussein Mohammed (2014) Long-term consumption effect of eurycoma longifolia jack on histopathological changes in the vital organs in rats. In: International Postgraduate Network IWNEST Conferences Bandung 2014, 5-6 December 2014, Bandung -Indonesia. http://www.aensiweb.com/AEB/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QP Physiology RB Pathology
spellingShingle	QP Physiology RB Pathology Alfaqeh, Hamoud Hussein Mohammed Long-term consumption effect of eurycoma longifolia jack on histopathological changes in the vital organs in rats
description	Introduction:The use of Eurycoma longifolia Jack (ELJ)has increased in Southeast Asia especially Malaysia where it is widely used as power enhancement agent. Its use has become nationwide in Malaysia and Indonesia in daily life as beverage to enhance energy and stamina especially among males. However, its effect on the safety of vital organs of the body has not been studied properly.Thus, the main objective of this study was to determine whether long-term use of ELJ has side effects on the vital organs such as Pancreas,Liver and Kidney in rats. Materials and methods: Three different concentrations of aqueous extract of ELJ were prepared and dissolved in distilled water. A total of 32 Sprague-Dawley male rats were used and randomly divided into three test groups and control. The test groups were given different doses (low dose 250 mg/kg bw, medium dose 500mg/kg bw and high dose 1000 mg/kg bw) of aqueous extract of ELJ,respectively. Control group was given distilled water alone. Doses were given orally and daily for 5 weeks. After 5 weeks,animals were sacrificed; whole liver tissues were obtained, fixed in 10 percent formaldehyde overnight for histological examination. Result: Histological observations showed mild to moderate degrees of hemorrhage,hepatocytes degeneration and severe fatty changes in liver tissue of the test groups treated with ELJ as compared to control. Conclusion: In conclusion, the long-term daily consumption of ELJ in large quantity as beverage may cause fatty changes, hemorrhage and hepatocytes degeneration in the liver tissue. The Pancreatic tissues on the three groups treated with different concentration doses do not show any necrosis or inflammation in the treated groups.
format	Conference or Workshop Item
author	Alfaqeh, Hamoud Hussein Mohammed
author_facet	Alfaqeh, Hamoud Hussein Mohammed
author_sort	Alfaqeh, Hamoud Hussein Mohammed
title	Long-term consumption effect of eurycoma longifolia jack on histopathological changes in the vital organs in rats
title_short	Long-term consumption effect of eurycoma longifolia jack on histopathological changes in the vital organs in rats
title_full	Long-term consumption effect of eurycoma longifolia jack on histopathological changes in the vital organs in rats
title_fullStr	Long-term consumption effect of eurycoma longifolia jack on histopathological changes in the vital organs in rats
title_full_unstemmed	Long-term consumption effect of eurycoma longifolia jack on histopathological changes in the vital organs in rats
title_sort	long-term consumption effect of eurycoma longifolia jack on histopathological changes in the vital organs in rats
publisher	AENSI Journals
publishDate	2014
url	http://irep.iium.edu.my/44056/ http://irep.iium.edu.my/44056/ http://irep.iium.edu.my/44056/1/ICACB-5th-6th__Dec_2014-_Bandung-_Indonesia.pdf
first_indexed	2023-09-18T21:02:40Z
last_indexed	2023-09-18T21:02:40Z
_version_	1777410727663894528

Long-term consumption effect of eurycoma longifolia jack on histopathological changes in the vital organs in rats

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