Evaluation of anti-diabetic properties of cosmos caudatus kunth leaves in obese-diabetic induced rat using metabolomics approach

Diabetes mellitus prevalence is increasing rapidly worldwide. It is resulted from the combination of impaired insulin secretion with reduced insulin sensitivity of the target tissues. The objective of this study is to evaluate metobolites profile in the serum of rats in different conditions (heal...

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Main Authors:	Khatib, Alfi, Perumal, Vikneswari, Abdul Hamid, Azizah, Abas, Faridah, Khozirah Saari, Intan, Ismail, Safinar, Ismail , Amin
Format:	Conference or Workshop Item
Language:	English English
Published:	2014
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/39564/ http://irep.iium.edu.my/39564/ http://irep.iium.edu.my/39564/1/IHCI_2014_Abstract_Book.pdf http://irep.iium.edu.my/39564/2/IHCI_2014_Programme_Book.pdf

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recordtype	eprints
spelling	iium-395642018-05-23T06:43:06Z http://irep.iium.edu.my/39564/ Evaluation of anti-diabetic properties of cosmos caudatus kunth leaves in obese-diabetic induced rat using metabolomics approach Khatib, Alfi Perumal, Vikneswari Abdul Hamid, Azizah Abas, Faridah Khozirah Saari, Intan Ismail, Safinar Ismail , Amin R Medicine (General) Diabetes mellitus prevalence is increasing rapidly worldwide. It is resulted from the combination of impaired insulin secretion with reduced insulin sensitivity of the target tissues. The objective of this study is to evaluate metobolites profile in the serum of rats in different conditions (healthy, diabetes, Cosmos caudatusand metformin treated) using NMR based-metabolomics approach. The 80 % ethanol extract of C. caudatus was force fed to diabetic rats. Streptozotocin was used to induce the obese rat to become diabetic (ob-db). Rats were divided into four groups: healthy rat, ob-db treated with 300 mg/kg metformin and ob-db treated with 200 mg/kg of C. caudatus. The NMR spectrum of serums were statistically calculated using multivariate data analysis to discriminate the groups and to identify the metabolites responsible for discrimination. Glucose level which was elevated in diabetic rats can be reduced to the normal range after metformin and C. caudatus treatment. Interestingly metformin caused elevation of ethanol, lactate and alanine which were not observed in C. caudatus treated rats. Other significant metabolites which have been identified were glucose, ethanol, alanine and lactate. This study suggested that C. caudatus has potential for the treatment of diabetes. 2014-12-03 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/39564/1/IHCI_2014_Abstract_Book.pdf application/pdf en http://irep.iium.edu.my/39564/2/IHCI_2014_Programme_Book.pdf Khatib, Alfi and Perumal, Vikneswari and Abdul Hamid, Azizah and Abas, Faridah and Khozirah Saari, Intan and Ismail, Safinar and Ismail , Amin (2014) Evaluation of anti-diabetic properties of cosmos caudatus kunth leaves in obese-diabetic induced rat using metabolomics approach. In: International Health Conference IIUM 2014, 3rd-4th December 2014, Kuantan. (Unpublished) http://www.iium.edu.my/ihci/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Khatib, Alfi Perumal, Vikneswari Abdul Hamid, Azizah Abas, Faridah Khozirah Saari, Intan Ismail, Safinar Ismail , Amin Evaluation of anti-diabetic properties of cosmos caudatus kunth leaves in obese-diabetic induced rat using metabolomics approach
description	Diabetes mellitus prevalence is increasing rapidly worldwide. It is resulted from the combination of impaired insulin secretion with reduced insulin sensitivity of the target tissues. The objective of this study is to evaluate metobolites profile in the serum of rats in different conditions (healthy, diabetes, Cosmos caudatusand metformin treated) using NMR based-metabolomics approach. The 80 % ethanol extract of C. caudatus was force fed to diabetic rats. Streptozotocin was used to induce the obese rat to become diabetic (ob-db). Rats were divided into four groups: healthy rat, ob-db treated with 300 mg/kg metformin and ob-db treated with 200 mg/kg of C. caudatus. The NMR spectrum of serums were statistically calculated using multivariate data analysis to discriminate the groups and to identify the metabolites responsible for discrimination. Glucose level which was elevated in diabetic rats can be reduced to the normal range after metformin and C. caudatus treatment. Interestingly metformin caused elevation of ethanol, lactate and alanine which were not observed in C. caudatus treated rats. Other significant metabolites which have been identified were glucose, ethanol, alanine and lactate. This study suggested that C. caudatus has potential for the treatment of diabetes.
format	Conference or Workshop Item
author	Khatib, Alfi Perumal, Vikneswari Abdul Hamid, Azizah Abas, Faridah Khozirah Saari, Intan Ismail, Safinar Ismail , Amin
author_facet	Khatib, Alfi Perumal, Vikneswari Abdul Hamid, Azizah Abas, Faridah Khozirah Saari, Intan Ismail, Safinar Ismail , Amin
author_sort	Khatib, Alfi
title	Evaluation of anti-diabetic properties of cosmos caudatus kunth leaves in obese-diabetic induced rat using metabolomics approach
title_short	Evaluation of anti-diabetic properties of cosmos caudatus kunth leaves in obese-diabetic induced rat using metabolomics approach
title_full	Evaluation of anti-diabetic properties of cosmos caudatus kunth leaves in obese-diabetic induced rat using metabolomics approach
title_fullStr	Evaluation of anti-diabetic properties of cosmos caudatus kunth leaves in obese-diabetic induced rat using metabolomics approach
title_full_unstemmed	Evaluation of anti-diabetic properties of cosmos caudatus kunth leaves in obese-diabetic induced rat using metabolomics approach
title_sort	evaluation of anti-diabetic properties of cosmos caudatus kunth leaves in obese-diabetic induced rat using metabolomics approach
publishDate	2014
url	http://irep.iium.edu.my/39564/ http://irep.iium.edu.my/39564/ http://irep.iium.edu.my/39564/1/IHCI_2014_Abstract_Book.pdf http://irep.iium.edu.my/39564/2/IHCI_2014_Programme_Book.pdf
first_indexed	2023-09-18T20:56:52Z
last_indexed	2023-09-18T20:56:52Z
_version_	1777410362189021184

Evaluation of anti-diabetic properties of cosmos caudatus kunth leaves in obese-diabetic induced rat using metabolomics approach

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