Selectively promiscuous opioid ligands: discovery of high affinity/low efficacy opioid ligands with substantial nociceptin opioid peptide receptor affinity

Selectively promiscuous opioid ligands: discovery of high affinity/low efficacy opioid ligands with substantial nociceptin opioid peptide receptor affinity

Emerging clinical and preclinical evidence suggests that a compound displaying high affinity for μ, κ, and δ opioid (MOP, KOP, and DOP) receptors and antagonist activity at each, coupled with moderate affinity and efficacy at nociceptin opioid peptide (NOP) receptors will have utility as a relapse p...

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Bibliographic Details
Main Authors: Kumar, Vinod, Ridzwan, Irna Elina, Grivas, Konstantinos, Lewis, John W, Clark, Mary J, Meurice, Claire, Jimenez-Gomez, Corina, Pogozheva, Irina, Mosberg, Henry, Traynor, John R, Husbands, Stephen M
Format: Article
Language:English
Published: American Chemical Society 2014
Subjects:
QD Chemistry
RS Pharmacy and materia medica
Online Access:http://irep.iium.edu.my/37816/
http://irep.iium.edu.my/37816/
http://irep.iium.edu.my/37816/
http://irep.iium.edu.my/37816/1/Irna_Elina_%28Journal_of_Medicinal_Chemistry%29.pdf

Internet

http://irep.iium.edu.my/37816/
http://irep.iium.edu.my/37816/
http://irep.iium.edu.my/37816/
http://irep.iium.edu.my/37816/1/Irna_Elina_%28Journal_of_Medicinal_Chemistry%29.pdf

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