Potential antidiabetic properties of G. mangostana Linn. on Streptozotocin-induced diabetic rats

Aim: The aim of the study was to evaluate the biochemical effects and histopathological alterations of the ethanolic extracts of G. mangostana pericarps (GME) on STZ-induced diabetic rats. Methods: Oral administration of GME at doses of 50, 100 and 200mg/kg b.w. were given to STZ-induced diabetic...

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Main Authors:	Bakhtiar, M. Taher, Tengku Zakaria, Tengku Muhammad Faris, Azad, Abul Kalam
Format:	Conference or Workshop Item
Language:	English English English
Published:	2014
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/37029/ http://irep.iium.edu.my/37029/ http://irep.iium.edu.my/37029/2/IRIIE_2014_-_IRIIE_Management_System.pdf http://irep.iium.edu.my/37029/3/Results_for_medal.pdf http://irep.iium.edu.my/37029/8/Taher.pdf

id	iium-37029
recordtype	eprints
spelling	iium-370292015-03-26T07:58:43Z http://irep.iium.edu.my/37029/ Potential antidiabetic properties of G. mangostana Linn. on Streptozotocin-induced diabetic rats Bakhtiar, M. Taher Tengku Zakaria, Tengku Muhammad Faris Azad, Abul Kalam RS Pharmacy and materia medica Aim: The aim of the study was to evaluate the biochemical effects and histopathological alterations of the ethanolic extracts of G. mangostana pericarps (GME) on STZ-induced diabetic rats. Methods: Oral administration of GME at doses of 50, 100 and 200mg/kg b.w. were given to STZ-induced diabetic and normoglycaemic albino rats. The serum biochemical parameters, enzymatic analysis and histopathological alterations were examined and compared to reference standard hypoglycamic drug, glibenclamide. Analytes including blood glucose, liver transminases viz. alanine aminotransferase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALT); lipid profile included triglycerides (TG), total cholesterol (TC), High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL) and Very Low Density Lipoprotein (VLDL); creatinine, urea and total protein were checked using standard test kits and reagents. Histological changes in the liver, kidney and pancreas of the animals were also examined. Results: The results obtained revealed a significant reduction of glucose level in GME with doses of 100mg/kg (p<0.001) and 200mg/kg (p<0.001) compared to 50mg/kg. Total cholesterol, serum triglyceride, LDL, VLDL, urea and creatinine were reduced in the treatment group while total protein contents and HDL level mildly elevated. Histological assessment revealed a reduction in lesions associated with diabetic state in STZ-induced rats. Conclusion: The implications of the results obtained especially reduction of glucose and improved biochemical function by G.mangostana are their potential use in management of diabetes and apparent effects on the liver, kidney and pancreas when administered in dose-dependent manner. 2014 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/37029/2/IRIIE_2014_-_IRIIE_Management_System.pdf application/pdf en http://irep.iium.edu.my/37029/3/Results_for_medal.pdf application/pdf en http://irep.iium.edu.my/37029/8/Taher.pdf Bakhtiar, M. Taher and Tengku Zakaria, Tengku Muhammad Faris and Azad, Abul Kalam (2014) Potential antidiabetic properties of G. mangostana Linn. on Streptozotocin-induced diabetic rats. In: IIUM Research, Invention & Innovation Exhibition (IRIIE 2014), 11-12 June 2014, CAC, IIUM Gombak. http://www.iium.edu.my/irie/14/index.php/result/8-irie2014/36-results-for-has
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Bakhtiar, M. Taher Tengku Zakaria, Tengku Muhammad Faris Azad, Abul Kalam Potential antidiabetic properties of G. mangostana Linn. on Streptozotocin-induced diabetic rats
description	Aim: The aim of the study was to evaluate the biochemical effects and histopathological alterations of the ethanolic extracts of G. mangostana pericarps (GME) on STZ-induced diabetic rats. Methods: Oral administration of GME at doses of 50, 100 and 200mg/kg b.w. were given to STZ-induced diabetic and normoglycaemic albino rats. The serum biochemical parameters, enzymatic analysis and histopathological alterations were examined and compared to reference standard hypoglycamic drug, glibenclamide. Analytes including blood glucose, liver transminases viz. alanine aminotransferase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALT); lipid profile included triglycerides (TG), total cholesterol (TC), High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL) and Very Low Density Lipoprotein (VLDL); creatinine, urea and total protein were checked using standard test kits and reagents. Histological changes in the liver, kidney and pancreas of the animals were also examined. Results: The results obtained revealed a significant reduction of glucose level in GME with doses of 100mg/kg (p<0.001) and 200mg/kg (p<0.001) compared to 50mg/kg. Total cholesterol, serum triglyceride, LDL, VLDL, urea and creatinine were reduced in the treatment group while total protein contents and HDL level mildly elevated. Histological assessment revealed a reduction in lesions associated with diabetic state in STZ-induced rats. Conclusion: The implications of the results obtained especially reduction of glucose and improved biochemical function by G.mangostana are their potential use in management of diabetes and apparent effects on the liver, kidney and pancreas when administered in dose-dependent manner.
format	Conference or Workshop Item
author	Bakhtiar, M. Taher Tengku Zakaria, Tengku Muhammad Faris Azad, Abul Kalam
author_facet	Bakhtiar, M. Taher Tengku Zakaria, Tengku Muhammad Faris Azad, Abul Kalam
author_sort	Bakhtiar, M. Taher
title	Potential antidiabetic properties of G. mangostana Linn. on Streptozotocin-induced diabetic rats
title_short	Potential antidiabetic properties of G. mangostana Linn. on Streptozotocin-induced diabetic rats
title_full	Potential antidiabetic properties of G. mangostana Linn. on Streptozotocin-induced diabetic rats
title_fullStr	Potential antidiabetic properties of G. mangostana Linn. on Streptozotocin-induced diabetic rats
title_full_unstemmed	Potential antidiabetic properties of G. mangostana Linn. on Streptozotocin-induced diabetic rats
title_sort	potential antidiabetic properties of g. mangostana linn. on streptozotocin-induced diabetic rats
publishDate	2014
url	http://irep.iium.edu.my/37029/ http://irep.iium.edu.my/37029/ http://irep.iium.edu.my/37029/2/IRIIE_2014_-_IRIIE_Management_System.pdf http://irep.iium.edu.my/37029/3/Results_for_medal.pdf http://irep.iium.edu.my/37029/8/Taher.pdf
first_indexed	2023-09-18T20:53:06Z
last_indexed	2023-09-18T20:53:06Z
_version_	1777410126043414528

Potential antidiabetic properties of G. mangostana Linn. on Streptozotocin-induced diabetic rats

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