Effect of intrapartum pethidine on the neonatal outcome: is it duration related?

Objectives: To study the effect of pethidine on the intrapartum fetal heart rate (FHR) pattern and to assess the neonatal outcome with regards to the interval between pethidine administration to delivery of the fetus. Materials: 73 healthy women intrapartum from labour suite hospital Tengku A...

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Main Authors:	Abdulwahab, Dalia F, Husin, Roziah, Rukaia, Busurerah, Awang, Mokhtar, Ismail, Rozihan
Format:	Article
Language:	English English
Published:	Elsevier BV 2012
Subjects:	RG Gynecology and obstetrics
Online Access:	http://irep.iium.edu.my/32312/ http://irep.iium.edu.my/32312/1/FIGO.pdf http://irep.iium.edu.my/32312/4/ScienceDirect_-_Search_Results__AUTHORS%28D_Abdulwahab%29.htm

id	iium-32312
recordtype	eprints
spelling	iium-323122013-10-17T03:48:09Z http://irep.iium.edu.my/32312/ Effect of intrapartum pethidine on the neonatal outcome: is it duration related? Abdulwahab, Dalia F Husin, Roziah Rukaia, Busurerah Awang, Mokhtar Ismail, Rozihan RG Gynecology and obstetrics Objectives: To study the effect of pethidine on the intrapartum fetal heart rate (FHR) pattern and to assess the neonatal outcome with regards to the interval between pethidine administration to delivery of the fetus. Materials: 73 healthy women intrapartum from labour suite hospital Tengku Ampuan Afzan, Kuantan, Malaysia. Methods: This is a prospective observational study done on 73 healthy consented women with singleton pregnancy at term. All fetus were normal, vertex presentation with reactive FHR tracing before pethidine administration. FHR recording were performed for 40 minutes prior to and one hour post pethidine. Cervical dilatation of all patients ≤4cm at time of pethidine administration. Intramuscular pethidine 1 mg/kg was given as an intrapartum analgesia. The study sample was divided into two groups, first group delivered within 4 hours and second group delivered more than 4 hours after the pethidine administration. The data were analysed by SSPS 17.0. Results: the mean age of the recruited patients is 28.15±6.15 years and mean gestational age of 39.14±1.094 weeks. The mean duration from pethidine administration to delivery is 296.48±173.65 minutes (4 hours and 56 minutes). Four (5.5%) cases had suspicious CTG 1 hour post pethidine, 1 with absence of acceleration for 45 minutes and 3 cases with early deceleration lasted for 60 to 90 minutes. Out of 73 patients, 38 babies delivered within 4 hours and 35 delivered after 4 hours of pethidine. All neonates delivered with good Apgar Score (AS), 8 at 1 minute and 9 at 5 minute except 1 with AS of 5 at 1 min and 7 at 5 min which delivered more than 4 hours after pethidine. Sixteen (21.9%) cases were admitted to the Neonatal Intensive Care Unit (NICU). Eleven (68.75%) cases were admitted due to neonatal sedation from the delivery group less than 4 hours after pethidine. Five (31.25%) cases from the delivery group more than 4 hours, 4 cases with a diagnosis of transient tachypnea of newborn and 1 secondary to meconium aspiration syndrome (MAS). All discharge to mother after 24 hours, non required ventilation apart from the one with MAS which required ventilation for one day and longer admission. Despite of the higher number of those require admission in the less than 4 hours group, it was not statistically significant with P value of 7.44. Conclusions: Pethidine can be used as an intrapartum analgesia which is safe, easily available without major effect on fetal heart rate pattern and neonatal outcome even if given in advance stage of labour. Elsevier BV 2012 Article PeerReviewed application/pdf en http://irep.iium.edu.my/32312/1/FIGO.pdf application/pdf en http://irep.iium.edu.my/32312/4/ScienceDirect_-_Search_Results__AUTHORS%28D_Abdulwahab%29.htm Abdulwahab, Dalia F and Husin, Roziah and Rukaia, Busurerah and Awang, Mokhtar and Ismail, Rozihan (2012) Effect of intrapartum pethidine on the neonatal outcome: is it duration related? International Journal of Gynecology and Obstetrics, 119 (S3). S807-S807. ISSN 0020-7292
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RG Gynecology and obstetrics
spellingShingle	RG Gynecology and obstetrics Abdulwahab, Dalia F Husin, Roziah Rukaia, Busurerah Awang, Mokhtar Ismail, Rozihan Effect of intrapartum pethidine on the neonatal outcome: is it duration related?
description	Objectives: To study the effect of pethidine on the intrapartum fetal heart rate (FHR) pattern and to assess the neonatal outcome with regards to the interval between pethidine administration to delivery of the fetus. Materials: 73 healthy women intrapartum from labour suite hospital Tengku Ampuan Afzan, Kuantan, Malaysia. Methods: This is a prospective observational study done on 73 healthy consented women with singleton pregnancy at term. All fetus were normal, vertex presentation with reactive FHR tracing before pethidine administration. FHR recording were performed for 40 minutes prior to and one hour post pethidine. Cervical dilatation of all patients ≤4cm at time of pethidine administration. Intramuscular pethidine 1 mg/kg was given as an intrapartum analgesia. The study sample was divided into two groups, first group delivered within 4 hours and second group delivered more than 4 hours after the pethidine administration. The data were analysed by SSPS 17.0. Results: the mean age of the recruited patients is 28.15±6.15 years and mean gestational age of 39.14±1.094 weeks. The mean duration from pethidine administration to delivery is 296.48±173.65 minutes (4 hours and 56 minutes). Four (5.5%) cases had suspicious CTG 1 hour post pethidine, 1 with absence of acceleration for 45 minutes and 3 cases with early deceleration lasted for 60 to 90 minutes. Out of 73 patients, 38 babies delivered within 4 hours and 35 delivered after 4 hours of pethidine. All neonates delivered with good Apgar Score (AS), 8 at 1 minute and 9 at 5 minute except 1 with AS of 5 at 1 min and 7 at 5 min which delivered more than 4 hours after pethidine. Sixteen (21.9%) cases were admitted to the Neonatal Intensive Care Unit (NICU). Eleven (68.75%) cases were admitted due to neonatal sedation from the delivery group less than 4 hours after pethidine. Five (31.25%) cases from the delivery group more than 4 hours, 4 cases with a diagnosis of transient tachypnea of newborn and 1 secondary to meconium aspiration syndrome (MAS). All discharge to mother after 24 hours, non required ventilation apart from the one with MAS which required ventilation for one day and longer admission. Despite of the higher number of those require admission in the less than 4 hours group, it was not statistically significant with P value of 7.44. Conclusions: Pethidine can be used as an intrapartum analgesia which is safe, easily available without major effect on fetal heart rate pattern and neonatal outcome even if given in advance stage of labour.
format	Article
author	Abdulwahab, Dalia F Husin, Roziah Rukaia, Busurerah Awang, Mokhtar Ismail, Rozihan
author_facet	Abdulwahab, Dalia F Husin, Roziah Rukaia, Busurerah Awang, Mokhtar Ismail, Rozihan
author_sort	Abdulwahab, Dalia F
title	Effect of intrapartum pethidine on the neonatal outcome: is it duration related?
title_short	Effect of intrapartum pethidine on the neonatal outcome: is it duration related?
title_full	Effect of intrapartum pethidine on the neonatal outcome: is it duration related?
title_fullStr	Effect of intrapartum pethidine on the neonatal outcome: is it duration related?
title_full_unstemmed	Effect of intrapartum pethidine on the neonatal outcome: is it duration related?
title_sort	effect of intrapartum pethidine on the neonatal outcome: is it duration related?
publisher	Elsevier BV
publishDate	2012
url	http://irep.iium.edu.my/32312/ http://irep.iium.edu.my/32312/1/FIGO.pdf http://irep.iium.edu.my/32312/4/ScienceDirect_-_Search_Results__AUTHORS%28D_Abdulwahab%29.htm
first_indexed	2023-09-18T20:46:39Z
last_indexed	2023-09-18T20:46:39Z
_version_	1777409719519936512

Effect of intrapartum pethidine on the neonatal outcome: is it duration related?

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