Anti-Proliferation Effects of Benzimidazole Derivatives on HCT-116 Colon Cancer and MCF-7 Breast Cancer Cell Lines
Benzimidazoles 1-4 were obtained using modified synthesis methods and studied for their ability to inhibit cell proliferation of colon cancer cell HCT-116 and breast cancer cell MCF-7 using MTT assays. In the HCT-116 cell line, benzimidazole 2 was found to have an IC50 value of 16.2±3.85 μg/mL and...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
National Cancer Center, Korea.
2012
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/28843/ http://irep.iium.edu.my/28843/ http://irep.iium.edu.my/28843/ http://irep.iium.edu.my/28843/1/Anti-Proliferation_Effects_of_Benzimidazole_Derivatives_on.pdf |
| Summary: | Benzimidazoles 1-4 were obtained using modified synthesis methods and studied for their ability to inhibit
cell proliferation of colon cancer cell HCT-116 and breast cancer cell MCF-7 using MTT assays. In the HCT-116
cell line, benzimidazole 2 was found to have an IC50 value of 16.2±3.85 μg/mL and benzimidazole 1 a value of
28.5±2.91 μg/mL, while that for benzimidazole 4 was 24.08±0.31 μg/mL. In the MCF-7 cell line, benzimidazole
4 had an IC50 value of 8.86±1.10 μg/mL, benzimidazole 2 a value of 30.29±6.39 μg/mL, and benzimidazole 1 a
value of 31.2±4.49 μg/mL. Benzimidazole 3 exerted no cytotoxity in either of the cell lines, with IC50 values >50
μg/mL. The results suggest that benzimidazoles derivatives may have chemotherapeutic potential for treatment
of both colon and breast cancers. |
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