Supercritical carbon dioxide extraction of bioactive flavonoid from strobilanthes crispus (Pecah kaca)

The bioactive flavonoid compounds of Strobilanthes crispus (Pecah Kaca) leaves obtained by using supercritical carbon dioxide (SC-CO2) extraction were investigated and the obtained crude extract yields were compared in order to select the best operation parameters. Since carbon dioxide is a non-pol...

Full description

Bibliographic Details
Main Authors:	Md. Salleh, Liza, Abdul Rahman, Russly, Bimakr, Mandana, Selamat, Jinap, A., Rahmat, Sarker, Md. Zaidul Islam, Abdul Hamid, Azizah
Format:	Article
Language:	English
Published:	Elsevier 2010
Subjects:	RM Therapeutics. Pharmacology RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/18308/ http://irep.iium.edu.my/18308/ http://irep.iium.edu.my/18308/ http://irep.iium.edu.my/18308/1/liza.pdf

id	iium-18308
recordtype	eprints
spelling	iium-183082012-03-19T06:37:01Z http://irep.iium.edu.my/18308/ Supercritical carbon dioxide extraction of bioactive flavonoid from strobilanthes crispus (Pecah kaca) Md. Salleh, Liza Abdul Rahman, Russly Bimakr, Mandana Selamat, Jinap A., Rahmat Sarker, Md. Zaidul Islam Abdul Hamid, Azizah RM Therapeutics. Pharmacology RS Pharmacy and materia medica The bioactive flavonoid compounds of Strobilanthes crispus (Pecah Kaca) leaves obtained by using supercritical carbon dioxide (SC-CO2) extraction were investigated and the obtained crude extract yields were compared in order to select the best operation parameters. Since carbon dioxide is a non-polar solvent, ethanolwas used as co-solvent to increase the polarity of the fluid. The studied parameters were pressure (100, 150 and 200 bar), temperature (40, 50 and 60 ◦C) and dynamic extraction time (40, 60 and 80 min). The optimum extraction condition occurred at 200 bar, 50 ◦C and 60 min. Based on the mean value, pressure had dominant effect on the extraction yield. Apart from the optimum SFE conditions two other conditions namely at minimum (100 bar, 40 ◦C, 40 min) and maximum (200 bar, 60 ◦C, 80 min) levels of each studied parameters as control runs were analyzed by HPLC to determine the major bioactive flavonoid compounds from S. crispus. Under the optimum conditions eight flavonoid compounds were identified; they were (+)-catechin, (−)-epicatechin, rutin, myricetin, luteolin, apigenin, naringenin and kaempferol. © 2009 The Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved. Keywords: Strobilanthes crispus; Bioactive flavonoid; Supercritical carbon dioxide extraction; HPLC Elsevier 2010 Article PeerReviewed application/pdf en http://irep.iium.edu.my/18308/1/liza.pdf Md. Salleh, Liza and Abdul Rahman, Russly and Bimakr, Mandana and Selamat, Jinap and A., Rahmat and Sarker, Md. Zaidul Islam and Abdul Hamid, Azizah (2010) Supercritical carbon dioxide extraction of bioactive flavonoid from strobilanthes crispus (Pecah kaca). Food and Bioproducts Processing, 88 (2-3). pp. 319-326. ISSN 0960-3085 http://www.sciencedirect.com/science/article/pii/S0960308509000169 http://dx.doi.org/10.1016/j.fbp.2009.02.001
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RM Therapeutics. Pharmacology RS Pharmacy and materia medica
spellingShingle	RM Therapeutics. Pharmacology RS Pharmacy and materia medica Md. Salleh, Liza Abdul Rahman, Russly Bimakr, Mandana Selamat, Jinap A., Rahmat Sarker, Md. Zaidul Islam Abdul Hamid, Azizah Supercritical carbon dioxide extraction of bioactive flavonoid from strobilanthes crispus (Pecah kaca)
description	The bioactive flavonoid compounds of Strobilanthes crispus (Pecah Kaca) leaves obtained by using supercritical carbon dioxide (SC-CO2) extraction were investigated and the obtained crude extract yields were compared in order to select the best operation parameters. Since carbon dioxide is a non-polar solvent, ethanolwas used as co-solvent to increase the polarity of the fluid. The studied parameters were pressure (100, 150 and 200 bar), temperature (40, 50 and 60 ◦C) and dynamic extraction time (40, 60 and 80 min). The optimum extraction condition occurred at 200 bar, 50 ◦C and 60 min. Based on the mean value, pressure had dominant effect on the extraction yield. Apart from the optimum SFE conditions two other conditions namely at minimum (100 bar, 40 ◦C, 40 min) and maximum (200 bar, 60 ◦C, 80 min) levels of each studied parameters as control runs were analyzed by HPLC to determine the major bioactive flavonoid compounds from S. crispus. Under the optimum conditions eight flavonoid compounds were identified; they were (+)-catechin, (−)-epicatechin, rutin, myricetin, luteolin, apigenin, naringenin and kaempferol. © 2009 The Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved. Keywords: Strobilanthes crispus; Bioactive flavonoid; Supercritical carbon dioxide extraction; HPLC
format	Article
author	Md. Salleh, Liza Abdul Rahman, Russly Bimakr, Mandana Selamat, Jinap A., Rahmat Sarker, Md. Zaidul Islam Abdul Hamid, Azizah
author_facet	Md. Salleh, Liza Abdul Rahman, Russly Bimakr, Mandana Selamat, Jinap A., Rahmat Sarker, Md. Zaidul Islam Abdul Hamid, Azizah
author_sort	Md. Salleh, Liza
title	Supercritical carbon dioxide extraction of bioactive flavonoid from strobilanthes crispus (Pecah kaca)
title_short	Supercritical carbon dioxide extraction of bioactive flavonoid from strobilanthes crispus (Pecah kaca)
title_full	Supercritical carbon dioxide extraction of bioactive flavonoid from strobilanthes crispus (Pecah kaca)
title_fullStr	Supercritical carbon dioxide extraction of bioactive flavonoid from strobilanthes crispus (Pecah kaca)
title_full_unstemmed	Supercritical carbon dioxide extraction of bioactive flavonoid from strobilanthes crispus (Pecah kaca)
title_sort	supercritical carbon dioxide extraction of bioactive flavonoid from strobilanthes crispus (pecah kaca)
publisher	Elsevier
publishDate	2010
url	http://irep.iium.edu.my/18308/ http://irep.iium.edu.my/18308/ http://irep.iium.edu.my/18308/ http://irep.iium.edu.my/18308/1/liza.pdf
first_indexed	2023-09-18T20:27:23Z
last_indexed	2023-09-18T20:27:23Z
_version_	1777408507359789056

Supercritical carbon dioxide extraction of bioactive flavonoid from strobilanthes crispus (Pecah kaca)

Similar Items