Antibiotic purification by using IMA adsorbents

The intensity to achieve highly efficient and economical separation process can be seen in developing of various methods in the recent year. While in purification of antibiotic there are many methods use such as using High performance liquid chromatography (HPLC) and Counter-current chromatography (...

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Main Author:	Abdul Rahim, Mohd Yusoff
Format:	Undergraduates Project Papers
Language:	English
Published:	2009
Subjects:	TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/852/ http://umpir.ump.edu.my/id/eprint/852/1/Abdul_Rahim_Mohd_Yusoff.pdf

id	ump-852
recordtype	eprints
spelling	ump-8522015-03-03T07:47:14Z http://umpir.ump.edu.my/id/eprint/852/ Antibiotic purification by using IMA adsorbents Abdul Rahim, Mohd Yusoff TP Chemical technology The intensity to achieve highly efficient and economical separation process can be seen in developing of various methods in the recent year. While in purification of antibiotic there are many methods use such as using High performance liquid chromatography (HPLC) and Counter-current chromatography (CCC). The purpose of this research is to develop immobilized metal ion affinity zeolite by using solid state ion exchange method to investigate the effect of pH, types of adsorbent using different metal into rifampicin adsorption capacity. Adsorption of rifampicin using zeolite has a greatly potential due to ability to scale up easily, and highly selective. It was found that the highest adsorption capacity for rifampicin occur at pH 8 with Zr-HBeta as adsorbent. H-beta zeolite give highest adsorption capacity because it has higher diameter size, surface area and pore volume compare to Y zeolite. Increasing the surface area and pore volume will give better chances of rifampicin to adsorb into adsorbent. Meanwhile, pH 8 gives the highest adsorption capacity because it is closer with the pKa2 value of rifampicin which is 7.9. While zirconium is the only transition metal containing both acidic and basic surface sites. So this will make it gives better adsorption capacity of rifampicin compare with ferum and nickel. The adsorption isotherm data of rifampicin was well correlated by the Langmuir model. 2009-04 Undergraduates Project Papers NonPeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/852/1/Abdul_Rahim_Mohd_Yusoff.pdf Abdul Rahim, Mohd Yusoff (2009) Antibiotic purification by using IMA adsorbents. Faculty of Chemical & Natural Resources Engineering, Universiti Malaysia Pahang.
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Abdul Rahim, Mohd Yusoff Antibiotic purification by using IMA adsorbents
description	The intensity to achieve highly efficient and economical separation process can be seen in developing of various methods in the recent year. While in purification of antibiotic there are many methods use such as using High performance liquid chromatography (HPLC) and Counter-current chromatography (CCC). The purpose of this research is to develop immobilized metal ion affinity zeolite by using solid state ion exchange method to investigate the effect of pH, types of adsorbent using different metal into rifampicin adsorption capacity. Adsorption of rifampicin using zeolite has a greatly potential due to ability to scale up easily, and highly selective. It was found that the highest adsorption capacity for rifampicin occur at pH 8 with Zr-HBeta as adsorbent. H-beta zeolite give highest adsorption capacity because it has higher diameter size, surface area and pore volume compare to Y zeolite. Increasing the surface area and pore volume will give better chances of rifampicin to adsorb into adsorbent. Meanwhile, pH 8 gives the highest adsorption capacity because it is closer with the pKa2 value of rifampicin which is 7.9. While zirconium is the only transition metal containing both acidic and basic surface sites. So this will make it gives better adsorption capacity of rifampicin compare with ferum and nickel. The adsorption isotherm data of rifampicin was well correlated by the Langmuir model.
format	Undergraduates Project Papers
author	Abdul Rahim, Mohd Yusoff
author_facet	Abdul Rahim, Mohd Yusoff
author_sort	Abdul Rahim, Mohd Yusoff
title	Antibiotic purification by using IMA adsorbents
title_short	Antibiotic purification by using IMA adsorbents
title_full	Antibiotic purification by using IMA adsorbents
title_fullStr	Antibiotic purification by using IMA adsorbents
title_full_unstemmed	Antibiotic purification by using IMA adsorbents
title_sort	antibiotic purification by using ima adsorbents
publishDate	2009
url	http://umpir.ump.edu.my/id/eprint/852/ http://umpir.ump.edu.my/id/eprint/852/1/Abdul_Rahim_Mohd_Yusoff.pdf
first_indexed	2023-09-18T21:53:28Z
last_indexed	2023-09-18T21:53:28Z
_version_	1777413923706765312

Antibiotic purification by using IMA adsorbents

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