Antibiotic purification by using zeolites adsorbent

Effective separation and purification of antibiotic has been an important issue in the pharmaceutical industries. A novel antibiotic adsorption has been developed in biotechnology to achieve high efficiency and economical separation processes. Application in separation and purification processes oft...

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Main Author:	Nur Munirah, Abd Wahab
Format:	Undergraduates Project Papers
Language:	English
Published:	2009
Subjects:	TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/826/ http://umpir.ump.edu.my/id/eprint/826/ http://umpir.ump.edu.my/id/eprint/826/1/Nur_Munirah_Abd_Wahab.pdf

id	ump-826
recordtype	eprints
spelling	ump-8262015-03-03T07:47:06Z http://umpir.ump.edu.my/id/eprint/826/ Antibiotic purification by using zeolites adsorbent Nur Munirah, Abd Wahab TP Chemical technology Effective separation and purification of antibiotic has been an important issue in the pharmaceutical industries. A novel antibiotic adsorption has been developed in biotechnology to achieve high efficiency and economical separation processes. Application in separation and purification processes often used the ability of zeolites and other molecular sieves to exclude larger molecules to enter the pores and admit smaller ones. In this study, three types of zeolites which are Y, Beta and ZSM-5 have been used to study the effect of their performance on the antibiotic purification. The zeolite is used as an immobilized metal ion affinity stationary phase for antibiotic purification. The adsorption of Rifampicin antibiotic using zeolites was studied. Rifampicin adsorbance was analyzed by using UV/VIS Spectrophotometer. The zeolite Beta is recognized to have highest adsorption capacity compared to zeolite Y and ZSM-5. The adsorption capacity of Rifampicin depends on their types of structure, pore size of the zeolite, surface area as well as pore volume of the zeolite. The effect of pH on adsorption capacity was studied at four different pHs, namely 5, 7, 8, and 9. It is found that the adsorption capacity is the highest at pH 8 which is the nearest to the pKa of Rifampicin. Increase in pH lower than pKa value result in increasing adsorption capacity. But,increase in pH higher than pKa value results decreasing adsorption capacity. This is postulate due to the electrostatics repulsion between antibiotic molecules and the surface of adsorbent. Lastly, it can be concluded that the most efficient zeolite is Beta at pH 8.The adsorption isotherms data on Rifampicin are fitted to the Langmuir model. 2009-04 Undergraduates Project Papers NonPeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/826/1/Nur_Munirah_Abd_Wahab.pdf Nur Munirah, Abd Wahab (2009) Antibiotic purification by using zeolites adsorbent. Faculty of Chemical & Natural Resources Engineering, Universiti Malaysia Pahang. http://iportal.ump.edu.my/lib/item?id=chamo:45457&theme=UMP2
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Nur Munirah, Abd Wahab Antibiotic purification by using zeolites adsorbent
description	Effective separation and purification of antibiotic has been an important issue in the pharmaceutical industries. A novel antibiotic adsorption has been developed in biotechnology to achieve high efficiency and economical separation processes. Application in separation and purification processes often used the ability of zeolites and other molecular sieves to exclude larger molecules to enter the pores and admit smaller ones. In this study, three types of zeolites which are Y, Beta and ZSM-5 have been used to study the effect of their performance on the antibiotic purification. The zeolite is used as an immobilized metal ion affinity stationary phase for antibiotic purification. The adsorption of Rifampicin antibiotic using zeolites was studied. Rifampicin adsorbance was analyzed by using UV/VIS Spectrophotometer. The zeolite Beta is recognized to have highest adsorption capacity compared to zeolite Y and ZSM-5. The adsorption capacity of Rifampicin depends on their types of structure, pore size of the zeolite, surface area as well as pore volume of the zeolite. The effect of pH on adsorption capacity was studied at four different pHs, namely 5, 7, 8, and 9. It is found that the adsorption capacity is the highest at pH 8 which is the nearest to the pKa of Rifampicin. Increase in pH lower than pKa value result in increasing adsorption capacity. But,increase in pH higher than pKa value results decreasing adsorption capacity. This is postulate due to the electrostatics repulsion between antibiotic molecules and the surface of adsorbent. Lastly, it can be concluded that the most efficient zeolite is Beta at pH 8.The adsorption isotherms data on Rifampicin are fitted to the Langmuir model.
format	Undergraduates Project Papers
author	Nur Munirah, Abd Wahab
author_facet	Nur Munirah, Abd Wahab
author_sort	Nur Munirah, Abd Wahab
title	Antibiotic purification by using zeolites adsorbent
title_short	Antibiotic purification by using zeolites adsorbent
title_full	Antibiotic purification by using zeolites adsorbent
title_fullStr	Antibiotic purification by using zeolites adsorbent
title_full_unstemmed	Antibiotic purification by using zeolites adsorbent
title_sort	antibiotic purification by using zeolites adsorbent
publishDate	2009
url	http://umpir.ump.edu.my/id/eprint/826/ http://umpir.ump.edu.my/id/eprint/826/ http://umpir.ump.edu.my/id/eprint/826/1/Nur_Munirah_Abd_Wahab.pdf
first_indexed	2023-09-18T21:53:25Z
last_indexed	2023-09-18T21:53:25Z
_version_	1777413920334544896

Antibiotic purification by using zeolites adsorbent

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