Preparation of Mesoporous Silica-Supported Chiral Amino Alcohols for the Enantioselective Addition of Diethylzinc to Aldehyde and Asymmetric Transfer Hydrogenation to Ketones
Optically active (−)-ephedrine, (−)-norephedrine, and (−)-prolinol were immobilized onto cubicmesoporousMCM-48 silica. The immobilized amino alcohols served as a heterogeneous chiral catalyst for the asymmetric addition of diethylzinc to aldehydes and transfer hydrogenation to ketones. The developed...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Publishing Corporation
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| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/8176/ http://umpir.ump.edu.my/id/eprint/8176/1/Sha_JNM-3.pdf |
| Summary: | Optically active (−)-ephedrine, (−)-norephedrine, and (−)-prolinol were immobilized onto cubicmesoporousMCM-48 silica. The immobilized amino alcohols served as a heterogeneous chiral catalyst for the asymmetric addition of diethylzinc to aldehydes and transfer hydrogenation to ketones. The developed catalytic process yielded optically enriches secondary aromatic alcohols with 92–99% conversion and 70–82% enantioselectivity. |
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