Synthesis and Biological Evaluation of Novel Substituted 1,3,4-thiadiazole and 2,6-di aryl substituted imidazo [2,1- b] [1,3,4]thiadiazole Derivatives

A new series of N-[5-(4-(alkyl/aryl)-3-nitro-phenyl)-[1,3,4-thiadiazol-2-yl]-2,2-dimethyl-propionamide 4(ael) and 6-(4-Methoxy-phenyl)-2-(4-alkyl/aryl)-3-nitro-phenyl)-Imidazo [2,1-b] [1,3,4] thiadiazole 6(ael) were synthesized starting from 5-(4-Fluoro-3-nitro-phenyl)-[1,3,4] thiadiazole-2-ylamine....

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Main Authors: Hegde, Gurumurthy, Boodappa, Chandrakantha, Isloor, Arun M., Shetty, Prakash, Sook, Fun Pang
Format: Article
Language:English
English
Published: Elsevier 2014
Subjects:
Online Access:http://umpir.ump.edu.my/id/eprint/8073/
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spelling ump-80732018-05-17T06:30:23Z http://umpir.ump.edu.my/id/eprint/8073/ Synthesis and Biological Evaluation of Novel Substituted 1,3,4-thiadiazole and 2,6-di aryl substituted imidazo [2,1- b] [1,3,4]thiadiazole Derivatives Hegde, Gurumurthy Boodappa, Chandrakantha Isloor, Arun M. Shetty, Prakash Sook, Fun Pang QD Chemistry QC Physics A new series of N-[5-(4-(alkyl/aryl)-3-nitro-phenyl)-[1,3,4-thiadiazol-2-yl]-2,2-dimethyl-propionamide 4(ael) and 6-(4-Methoxy-phenyl)-2-(4-alkyl/aryl)-3-nitro-phenyl)-Imidazo [2,1-b] [1,3,4] thiadiazole 6(ael) were synthesized starting from 5-(4-Fluoro-3-nitro-phenyl)-[1,3,4] thiadiazole-2-ylamine. The synthesized compounds were characterized by IR, NMR, mass spectral and elemental analysis. All the compounds were tested for antibacterial and antifungal activities. The antimicrobial activities of the compounds were assessed by well plate method (zone of inhibition). Compounds 4a,4c and 6e,6g displayed appreciable activity at the concentration 0.5 - 1.0 mg/mL. Elsevier 2014 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/8073/1/Synthesis%20and%20Biological%20Evaluation%20of%20Novel%20Substituted%201%2C3%2C4-Thiadiazole%20and%202%2C6-Di%20Aryl%20Substituted%20Imidazo%20%5B2%2C1-B%5D%20%5B1%2C3%2C4%5D%20Thiadiazole%20Derivatives.pdf application/pdf en http://umpir.ump.edu.my/id/eprint/8073/7/Synthesis%20and%20Biological%20Evaluation%20of%20Novel%20Substituted%201%2C3%2C4-Thiadiazole%20and%202%2C6-Di%20Aryl%20Substituted%20Imidazo%20%5B2%2C1-B%5D%20%5B1%2C3%2C4%5D%20Thiadiazole%20Derivatives.pdf Hegde, Gurumurthy and Boodappa, Chandrakantha and Isloor, Arun M. and Shetty, Prakash and Sook, Fun Pang (2014) Synthesis and Biological Evaluation of Novel Substituted 1,3,4-thiadiazole and 2,6-di aryl substituted imidazo [2,1- b] [1,3,4]thiadiazole Derivatives. European Journal of Medicinal Chemistry, 71. pp. 316-323. ISSN 0223-5234 (prin); 1768-3254 (online) http://dx.doi.org/10.1016/j.ejmech.2013.10.056 DOI: 10.1016/j.ejmech.2013.10.056
repository_type Digital Repository
institution_category Local University
institution Universiti Malaysia Pahang
building UMP Institutional Repository
collection Online Access
language English
English
topic QD Chemistry
QC Physics
spellingShingle QD Chemistry
QC Physics
Hegde, Gurumurthy
Boodappa, Chandrakantha
Isloor, Arun M.
Shetty, Prakash
Sook, Fun Pang
Synthesis and Biological Evaluation of Novel Substituted 1,3,4-thiadiazole and 2,6-di aryl substituted imidazo [2,1- b] [1,3,4]thiadiazole Derivatives
description A new series of N-[5-(4-(alkyl/aryl)-3-nitro-phenyl)-[1,3,4-thiadiazol-2-yl]-2,2-dimethyl-propionamide 4(ael) and 6-(4-Methoxy-phenyl)-2-(4-alkyl/aryl)-3-nitro-phenyl)-Imidazo [2,1-b] [1,3,4] thiadiazole 6(ael) were synthesized starting from 5-(4-Fluoro-3-nitro-phenyl)-[1,3,4] thiadiazole-2-ylamine. The synthesized compounds were characterized by IR, NMR, mass spectral and elemental analysis. All the compounds were tested for antibacterial and antifungal activities. The antimicrobial activities of the compounds were assessed by well plate method (zone of inhibition). Compounds 4a,4c and 6e,6g displayed appreciable activity at the concentration 0.5 - 1.0 mg/mL.
format Article
author Hegde, Gurumurthy
Boodappa, Chandrakantha
Isloor, Arun M.
Shetty, Prakash
Sook, Fun Pang
author_facet Hegde, Gurumurthy
Boodappa, Chandrakantha
Isloor, Arun M.
Shetty, Prakash
Sook, Fun Pang
author_sort Hegde, Gurumurthy
title Synthesis and Biological Evaluation of Novel Substituted 1,3,4-thiadiazole and 2,6-di aryl substituted imidazo [2,1- b] [1,3,4]thiadiazole Derivatives
title_short Synthesis and Biological Evaluation of Novel Substituted 1,3,4-thiadiazole and 2,6-di aryl substituted imidazo [2,1- b] [1,3,4]thiadiazole Derivatives
title_full Synthesis and Biological Evaluation of Novel Substituted 1,3,4-thiadiazole and 2,6-di aryl substituted imidazo [2,1- b] [1,3,4]thiadiazole Derivatives
title_fullStr Synthesis and Biological Evaluation of Novel Substituted 1,3,4-thiadiazole and 2,6-di aryl substituted imidazo [2,1- b] [1,3,4]thiadiazole Derivatives
title_full_unstemmed Synthesis and Biological Evaluation of Novel Substituted 1,3,4-thiadiazole and 2,6-di aryl substituted imidazo [2,1- b] [1,3,4]thiadiazole Derivatives
title_sort synthesis and biological evaluation of novel substituted 1,3,4-thiadiazole and 2,6-di aryl substituted imidazo [2,1- b] [1,3,4]thiadiazole derivatives
publisher Elsevier
publishDate 2014
url http://umpir.ump.edu.my/id/eprint/8073/
http://umpir.ump.edu.my/id/eprint/8073/
http://umpir.ump.edu.my/id/eprint/8073/
http://umpir.ump.edu.my/id/eprint/8073/1/Synthesis%20and%20Biological%20Evaluation%20of%20Novel%20Substituted%201%2C3%2C4-Thiadiazole%20and%202%2C6-Di%20Aryl%20Substituted%20Imidazo%20%5B2%2C1-B%5D%20%5B1%2C3%2C4%5D%20Thiadiazole%20Derivatives.pdf
http://umpir.ump.edu.my/id/eprint/8073/7/Synthesis%20and%20Biological%20Evaluation%20of%20Novel%20Substituted%201%2C3%2C4-Thiadiazole%20and%202%2C6-Di%20Aryl%20Substituted%20Imidazo%20%5B2%2C1-B%5D%20%5B1%2C3%2C4%5D%20Thiadiazole%20Derivatives.pdf
first_indexed 2023-09-18T22:05:21Z
last_indexed 2023-09-18T22:05:21Z
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