Engineered Andrographolide Nanosystems for Smart Recovery in Hepatotoxic Conditions

Andrographolide (AG) is one of the most potent labdane diterpenoid-type free radical scavengers available from plant sources. The compound is the principal bioactive component in Andrographis paniculata leaf extracts, and is responsible for anti-inflammatory, anticancer, and immunomodulatory activit...

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Main Authors: Roy, Partha, Das, Suvadra, Auddy, Runa Ghosh, Mukherjee, Arup
Format: Article
Language:English
Published: Dovepress 2014
Subjects:
Online Access:http://umpir.ump.edu.my/id/eprint/8009/
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http://umpir.ump.edu.my/id/eprint/8009/
http://umpir.ump.edu.my/id/eprint/8009/1/dr.partha_IJN-65262-engineered-andrographolide-nanosystems-for-smart-recovery-in_100914.pdf
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spelling ump-80092018-05-22T06:48:16Z http://umpir.ump.edu.my/id/eprint/8009/ Engineered Andrographolide Nanosystems for Smart Recovery in Hepatotoxic Conditions Roy, Partha Das, Suvadra Auddy, Runa Ghosh Mukherjee, Arup T Technology (General) Andrographolide (AG) is one of the most potent labdane diterpenoid-type free radical scavengers available from plant sources. The compound is the principal bioactive component in Andrographis paniculata leaf extracts, and is responsible for anti-inflammatory, anticancer, and immunomodulatory activity. The application of AG in therapeutics, however, is severely constrained, due to its low aqueous solubility, short biological half-life, and poor cellular permeability. Engineered nanoparticles in biodegradable polymer systems were therefore conceived as one solution to aid in further drug-like applications of AG. In this study, a cationic modified poly(lactic-co-glycolic) acid nanosystem was applied for evaluation against experimental mouse hepatotoxic conditions. Biopolymeric nanoparticles of hydrodynamic size of 229.7±17.17 nm and ζ-potential +34.4±1.87 mV facilitated marked restoration in liver functions and oxidative stress markers. Superior dissolution for bioactive AG, hepatic residence, and favorable cytokine regulation in the liver tissues are some of the factors responsible for the newer nanosystemassisted rapid recovery. Dovepress 2014 Article PeerReviewed application/pdf en cc_by_nc http://umpir.ump.edu.my/id/eprint/8009/1/dr.partha_IJN-65262-engineered-andrographolide-nanosystems-for-smart-recovery-in_100914.pdf Roy, Partha and Das, Suvadra and Auddy, Runa Ghosh and Mukherjee, Arup (2014) Engineered Andrographolide Nanosystems for Smart Recovery in Hepatotoxic Conditions. International Journal of Nanomedicine, 9 (1). pp. 4723-4735. ISSN 1178-2013 http://dx.doi.org/10.2147/IJN.S65262 DOI: 10.2147/IJN.S65262
repository_type Digital Repository
institution_category Local University
institution Universiti Malaysia Pahang
building UMP Institutional Repository
collection Online Access
language English
topic T Technology (General)
spellingShingle T Technology (General)
Roy, Partha
Das, Suvadra
Auddy, Runa Ghosh
Mukherjee, Arup
Engineered Andrographolide Nanosystems for Smart Recovery in Hepatotoxic Conditions
description Andrographolide (AG) is one of the most potent labdane diterpenoid-type free radical scavengers available from plant sources. The compound is the principal bioactive component in Andrographis paniculata leaf extracts, and is responsible for anti-inflammatory, anticancer, and immunomodulatory activity. The application of AG in therapeutics, however, is severely constrained, due to its low aqueous solubility, short biological half-life, and poor cellular permeability. Engineered nanoparticles in biodegradable polymer systems were therefore conceived as one solution to aid in further drug-like applications of AG. In this study, a cationic modified poly(lactic-co-glycolic) acid nanosystem was applied for evaluation against experimental mouse hepatotoxic conditions. Biopolymeric nanoparticles of hydrodynamic size of 229.7±17.17 nm and ζ-potential +34.4±1.87 mV facilitated marked restoration in liver functions and oxidative stress markers. Superior dissolution for bioactive AG, hepatic residence, and favorable cytokine regulation in the liver tissues are some of the factors responsible for the newer nanosystemassisted rapid recovery.
format Article
author Roy, Partha
Das, Suvadra
Auddy, Runa Ghosh
Mukherjee, Arup
author_facet Roy, Partha
Das, Suvadra
Auddy, Runa Ghosh
Mukherjee, Arup
author_sort Roy, Partha
title Engineered Andrographolide Nanosystems for Smart Recovery in Hepatotoxic Conditions
title_short Engineered Andrographolide Nanosystems for Smart Recovery in Hepatotoxic Conditions
title_full Engineered Andrographolide Nanosystems for Smart Recovery in Hepatotoxic Conditions
title_fullStr Engineered Andrographolide Nanosystems for Smart Recovery in Hepatotoxic Conditions
title_full_unstemmed Engineered Andrographolide Nanosystems for Smart Recovery in Hepatotoxic Conditions
title_sort engineered andrographolide nanosystems for smart recovery in hepatotoxic conditions
publisher Dovepress
publishDate 2014
url http://umpir.ump.edu.my/id/eprint/8009/
http://umpir.ump.edu.my/id/eprint/8009/
http://umpir.ump.edu.my/id/eprint/8009/
http://umpir.ump.edu.my/id/eprint/8009/1/dr.partha_IJN-65262-engineered-andrographolide-nanosystems-for-smart-recovery-in_100914.pdf
first_indexed 2023-09-18T22:05:14Z
last_indexed 2023-09-18T22:05:14Z
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