Synthesis, Structural Analysis and Screening of Some Novel 5-Substituted Aryl/Aralkyl-1,3,4-Oxadiazol-2-Yl 4-(Morpholin-4-Ylsulfonyl)Benzyl Sulfides as Potential Antibacterial Agents

A series of new 5-substituted aryl/aralkyl-1,3,4-oxadiazol-2-yl 4-(morpholin-4-ylsulfonyl)benzyl sulfides 6a-k were synthesized by converting multifarious aryl/aralkyl organic acids 1a-k successively into corresponding esters 2a-k, hydrazides 3a-k and 5-substituted aryl/aralkyl-1,3,4-oxadiazole-2-th...

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Main Authors: Akhtar, Muhammad Nadeem, Rehman, Aziz-ur, Gul, Samreen, Abbasi, Muhammad Athar, Nafeesa, Khadija, Ahmad, Irshad, Afzal, Saira
Format: Article
Language:English
Published: Taylor & Francis 2015
Subjects:
Online Access:http://umpir.ump.edu.my/id/eprint/7989/
http://umpir.ump.edu.my/id/eprint/7989/
http://umpir.ump.edu.my/id/eprint/7989/
http://umpir.ump.edu.my/id/eprint/7989/1/Synthesis%2C%20Structural%20Analysis%2C%20and%20Screening%20of%20Some%20Novel%205-Substituted%20Aryl.pdf
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recordtype eprints
spelling ump-79892018-08-24T02:05:50Z http://umpir.ump.edu.my/id/eprint/7989/ Synthesis, Structural Analysis and Screening of Some Novel 5-Substituted Aryl/Aralkyl-1,3,4-Oxadiazol-2-Yl 4-(Morpholin-4-Ylsulfonyl)Benzyl Sulfides as Potential Antibacterial Agents Akhtar, Muhammad Nadeem Rehman, Aziz-ur Gul, Samreen Abbasi, Muhammad Athar Nafeesa, Khadija Ahmad, Irshad Afzal, Saira QD Chemistry A series of new 5-substituted aryl/aralkyl-1,3,4-oxadiazol-2-yl 4-(morpholin-4-ylsulfonyl)benzyl sulfides 6a-k were synthesized by converting multifarious aryl/aralkyl organic acids 1a-k successively into corresponding esters 2a-k, hydrazides 3a-k and 5-substituted aryl/aralkyl-1,3,4-oxadiazole-2-thiols 4a-k. Finally, the target compounds, 6a-k were prepared by stirring 5-substituted-1,3,4-oxadiazole-2-thiols with 4-(4-(bromomethyl)phenylsulfonyl) morpholine (5) in the presence of N,N-dimethylformamide (DMF) and sodium hydride (NaH). The structures of the newly synthesized compounds were elucidated by spectroscopic techniques. In addition, the anti-bacterial activity of all the synthesized compounds was investigated in vitro against Gram-positive and Gram-negative bacteria by using ciprofloxacin as reference standard drug and the results showed that some of the tested compounds possessed good anti-bacterial activity. Taylor & Francis 2015 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/7989/1/Synthesis%2C%20Structural%20Analysis%2C%20and%20Screening%20of%20Some%20Novel%205-Substituted%20Aryl.pdf Akhtar, Muhammad Nadeem and Rehman, Aziz-ur and Gul, Samreen and Abbasi, Muhammad Athar and Nafeesa, Khadija and Ahmad, Irshad and Afzal, Saira (2015) Synthesis, Structural Analysis and Screening of Some Novel 5-Substituted Aryl/Aralkyl-1,3,4-Oxadiazol-2-Yl 4-(Morpholin-4-Ylsulfonyl)Benzyl Sulfides as Potential Antibacterial Agents. Phosphorus, Sulfur, and Silicon and the Related Elements. ISSN 1042-6507 (print); 1563-5325 (online) http://dx.doi.org/10.1080/10426507.2014.965816 DOI: 10.1080/10426507.2014.965816
repository_type Digital Repository
institution_category Local University
institution Universiti Malaysia Pahang
building UMP Institutional Repository
collection Online Access
language English
topic QD Chemistry
spellingShingle QD Chemistry
Akhtar, Muhammad Nadeem
Rehman, Aziz-ur
Gul, Samreen
Abbasi, Muhammad Athar
Nafeesa, Khadija
Ahmad, Irshad
Afzal, Saira
Synthesis, Structural Analysis and Screening of Some Novel 5-Substituted Aryl/Aralkyl-1,3,4-Oxadiazol-2-Yl 4-(Morpholin-4-Ylsulfonyl)Benzyl Sulfides as Potential Antibacterial Agents
description A series of new 5-substituted aryl/aralkyl-1,3,4-oxadiazol-2-yl 4-(morpholin-4-ylsulfonyl)benzyl sulfides 6a-k were synthesized by converting multifarious aryl/aralkyl organic acids 1a-k successively into corresponding esters 2a-k, hydrazides 3a-k and 5-substituted aryl/aralkyl-1,3,4-oxadiazole-2-thiols 4a-k. Finally, the target compounds, 6a-k were prepared by stirring 5-substituted-1,3,4-oxadiazole-2-thiols with 4-(4-(bromomethyl)phenylsulfonyl) morpholine (5) in the presence of N,N-dimethylformamide (DMF) and sodium hydride (NaH). The structures of the newly synthesized compounds were elucidated by spectroscopic techniques. In addition, the anti-bacterial activity of all the synthesized compounds was investigated in vitro against Gram-positive and Gram-negative bacteria by using ciprofloxacin as reference standard drug and the results showed that some of the tested compounds possessed good anti-bacterial activity.
format Article
author Akhtar, Muhammad Nadeem
Rehman, Aziz-ur
Gul, Samreen
Abbasi, Muhammad Athar
Nafeesa, Khadija
Ahmad, Irshad
Afzal, Saira
author_facet Akhtar, Muhammad Nadeem
Rehman, Aziz-ur
Gul, Samreen
Abbasi, Muhammad Athar
Nafeesa, Khadija
Ahmad, Irshad
Afzal, Saira
author_sort Akhtar, Muhammad Nadeem
title Synthesis, Structural Analysis and Screening of Some Novel 5-Substituted Aryl/Aralkyl-1,3,4-Oxadiazol-2-Yl 4-(Morpholin-4-Ylsulfonyl)Benzyl Sulfides as Potential Antibacterial Agents
title_short Synthesis, Structural Analysis and Screening of Some Novel 5-Substituted Aryl/Aralkyl-1,3,4-Oxadiazol-2-Yl 4-(Morpholin-4-Ylsulfonyl)Benzyl Sulfides as Potential Antibacterial Agents
title_full Synthesis, Structural Analysis and Screening of Some Novel 5-Substituted Aryl/Aralkyl-1,3,4-Oxadiazol-2-Yl 4-(Morpholin-4-Ylsulfonyl)Benzyl Sulfides as Potential Antibacterial Agents
title_fullStr Synthesis, Structural Analysis and Screening of Some Novel 5-Substituted Aryl/Aralkyl-1,3,4-Oxadiazol-2-Yl 4-(Morpholin-4-Ylsulfonyl)Benzyl Sulfides as Potential Antibacterial Agents
title_full_unstemmed Synthesis, Structural Analysis and Screening of Some Novel 5-Substituted Aryl/Aralkyl-1,3,4-Oxadiazol-2-Yl 4-(Morpholin-4-Ylsulfonyl)Benzyl Sulfides as Potential Antibacterial Agents
title_sort synthesis, structural analysis and screening of some novel 5-substituted aryl/aralkyl-1,3,4-oxadiazol-2-yl 4-(morpholin-4-ylsulfonyl)benzyl sulfides as potential antibacterial agents
publisher Taylor & Francis
publishDate 2015
url http://umpir.ump.edu.my/id/eprint/7989/
http://umpir.ump.edu.my/id/eprint/7989/
http://umpir.ump.edu.my/id/eprint/7989/
http://umpir.ump.edu.my/id/eprint/7989/1/Synthesis%2C%20Structural%20Analysis%2C%20and%20Screening%20of%20Some%20Novel%205-Substituted%20Aryl.pdf
first_indexed 2023-09-18T22:05:12Z
last_indexed 2023-09-18T22:05:12Z
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