Engineered Silybin Nanoparticles Educe Efficient Control in Experimental Diabetes

Silybin, is one imminent therapeutic for drug induced hepatotoxicity, human prostrate adenocarcinoma and other degenerative organ diseases. Recent evidences suggest that silybin influences gluconeogenesis pathways favorably and is beneficial in the treatment of type 1 and type 2 diabetes. The compou...

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Main Authors:	Roy, Partha, Das, Suvadra, Pal, Rajat, Auddy, Runa Ghosh, Chakraborti, Abhay Sankar, Mukherjee, Arup
Format:	Article
Language:	English
Published:	Public Library of Science 2014
Subjects:	TA Engineering (General). Civil engineering (General)
Online Access:	http://umpir.ump.edu.my/id/eprint/7962/ http://umpir.ump.edu.my/id/eprint/7962/ http://umpir.ump.edu.my/id/eprint/7962/ http://umpir.ump.edu.my/id/eprint/7962/1/ftek-2014-ParthaRoy.pdf

id	ump-7962
recordtype	eprints
spelling	ump-79622018-05-22T06:51:23Z http://umpir.ump.edu.my/id/eprint/7962/ Engineered Silybin Nanoparticles Educe Efficient Control in Experimental Diabetes Roy, Partha Das, Suvadra Pal, Rajat Auddy, Runa Ghosh Chakraborti, Abhay Sankar Mukherjee, Arup TA Engineering (General). Civil engineering (General) Silybin, is one imminent therapeutic for drug induced hepatotoxicity, human prostrate adenocarcinoma and other degenerative organ diseases. Recent evidences suggest that silybin influences gluconeogenesis pathways favorably and is beneficial in the treatment of type 1 and type 2 diabetes. The compound however is constrained due to solubility (0.4 mg/mL) and bioavailabilty limitations. Appropriate nanoparticle design for silybin in biocompatible polymers was thus proposed as a probable solution for therapeutic inadequacy. New surface engineered biopolymeric nanoparticles with high silybin encapsulation efficiency of 92.11% and zeta potential of +21 mV were designed. Both the pure compound and the nanoparticles were evaluated in vivo for the first time in experimental diabetic conditions. Animal health recovered substantially and the blood glucose levels came down to near normal values after 28 days treatment schedule with the engineered nanoparticles. Restoration from hyperglycemic damage condition was traced to serum insulin regeneration. Serum insulin recovered from the streptozotocin induced pancreatic damage levels of 0.17±0.01 µg/lit to 0.57±0.11 µg/lit after nanoparticle treatment. Significant reduction in glycated hemoglobin level, and restoration of liver glycogen content were some of the other interesting observations. Engineered silybin nanoparticle assisted recovery in diabetic conditions was reasoned due to improved silybin dissolution, passive transport in nanoscale, and restoration of antioxidant status. Public Library of Science 2014 Article PeerReviewed application/pdf en cc_by http://umpir.ump.edu.my/id/eprint/7962/1/ftek-2014-ParthaRoy.pdf Roy, Partha and Das, Suvadra and Pal, Rajat and Auddy, Runa Ghosh and Chakraborti, Abhay Sankar and Mukherjee, Arup (2014) Engineered Silybin Nanoparticles Educe Efficient Control in Experimental Diabetes. PLoS ONE, 9 (7). pp. 1-13. ISSN 1932-6203 http://dx.doi.org/10.1371/journal.pone.0101818 DOI: 10.1371/journal.pone.0101818
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	TA Engineering (General). Civil engineering (General)
spellingShingle	TA Engineering (General). Civil engineering (General) Roy, Partha Das, Suvadra Pal, Rajat Auddy, Runa Ghosh Chakraborti, Abhay Sankar Mukherjee, Arup Engineered Silybin Nanoparticles Educe Efficient Control in Experimental Diabetes
description	Silybin, is one imminent therapeutic for drug induced hepatotoxicity, human prostrate adenocarcinoma and other degenerative organ diseases. Recent evidences suggest that silybin influences gluconeogenesis pathways favorably and is beneficial in the treatment of type 1 and type 2 diabetes. The compound however is constrained due to solubility (0.4 mg/mL) and bioavailabilty limitations. Appropriate nanoparticle design for silybin in biocompatible polymers was thus proposed as a probable solution for therapeutic inadequacy. New surface engineered biopolymeric nanoparticles with high silybin encapsulation efficiency of 92.11% and zeta potential of +21 mV were designed. Both the pure compound and the nanoparticles were evaluated in vivo for the first time in experimental diabetic conditions. Animal health recovered substantially and the blood glucose levels came down to near normal values after 28 days treatment schedule with the engineered nanoparticles. Restoration from hyperglycemic damage condition was traced to serum insulin regeneration. Serum insulin recovered from the streptozotocin induced pancreatic damage levels of 0.17±0.01 µg/lit to 0.57±0.11 µg/lit after nanoparticle treatment. Significant reduction in glycated hemoglobin level, and restoration of liver glycogen content were some of the other interesting observations. Engineered silybin nanoparticle assisted recovery in diabetic conditions was reasoned due to improved silybin dissolution, passive transport in nanoscale, and restoration of antioxidant status.
format	Article
author	Roy, Partha Das, Suvadra Pal, Rajat Auddy, Runa Ghosh Chakraborti, Abhay Sankar Mukherjee, Arup
author_facet	Roy, Partha Das, Suvadra Pal, Rajat Auddy, Runa Ghosh Chakraborti, Abhay Sankar Mukherjee, Arup
author_sort	Roy, Partha
title	Engineered Silybin Nanoparticles Educe Efficient Control in Experimental Diabetes
title_short	Engineered Silybin Nanoparticles Educe Efficient Control in Experimental Diabetes
title_full	Engineered Silybin Nanoparticles Educe Efficient Control in Experimental Diabetes
title_fullStr	Engineered Silybin Nanoparticles Educe Efficient Control in Experimental Diabetes
title_full_unstemmed	Engineered Silybin Nanoparticles Educe Efficient Control in Experimental Diabetes
title_sort	engineered silybin nanoparticles educe efficient control in experimental diabetes
publisher	Public Library of Science
publishDate	2014
url	http://umpir.ump.edu.my/id/eprint/7962/ http://umpir.ump.edu.my/id/eprint/7962/ http://umpir.ump.edu.my/id/eprint/7962/ http://umpir.ump.edu.my/id/eprint/7962/1/ftek-2014-ParthaRoy.pdf
first_indexed	2023-09-18T22:05:09Z
last_indexed	2023-09-18T22:05:09Z
_version_	1777414658979790848

Engineered Silybin Nanoparticles Educe Efficient Control in Experimental Diabetes

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