Simulation of Transdermal Drug Delivery System for Breast Cancer Therapy Using COMSOL
The objective of this paper is to study the effectiveness if the new method of breast cancer therapy, which is the application transdermal patch for the drug delivery system through the largest organ of human body, the skin. This study was done by simulating the process of drug diffusion using multi...
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| Format: | Undergraduates Project Papers |
| Language: | English |
| Published: |
2012
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| Online Access: | http://umpir.ump.edu.my/id/eprint/7167/ http://umpir.ump.edu.my/id/eprint/7167/ http://umpir.ump.edu.my/id/eprint/7167/1/CD7138.pdf |
| Summary: | The objective of this paper is to study the effectiveness if the new method of breast cancer therapy, which is the application transdermal patch for the drug delivery system through the largest organ of human body, the skin. This study was done by simulating the process of drug diffusion using multiphysics software, COMSOL. For this study, we are using two types of drugs which have different physical and chemical properties as the subject, which is Paclitaxel and Doxorubicin. The simulation are done by obtaining the information such as the molecular weight and specific diffusivity of drugs through breast tissue until it reaches the targeted cancerous area. The simulation is computed using multiphysics software- COMSOL, to see how fast the drugs will be delivered to the targeted cancer cell. The effectiveness of this method of therapy by is studied by manipulating the properties of the type of drugs, the diffusivity of the drugs and the volume of the breast modeling. All of these parameters are manipulated by designing mathematical models governed by Fick‟s Law of diffusion. The differences of the concentration of drug on specific depth of breast tissue are shown by a color spectrum after the simulation was done. The application of transdermal patch in breast cancer therapy is the new type of drugs delivery system which lately has been the subjects of numerous researches, as it has been proven to be more advantageous than normal chemotherapy. The dosage of drug needs to be taken by the patients can be reduced significantly as this system is more topical and it is very specific, as the drugs applied to the skin will be absorbed and straightly attack the targeted cancer cell. Compared to normal chemotherapy, the drug pathway does not go through the vascular system or bloodstream, and it can reduce the side effects brought about by the strong drugs to the body of the patients. By doing this study, further development of this new type of breast cancer therapy can be done, so it can be creates more understanding and optimized as the primary type of breast cancer therapy. |
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