Microencapsulation and Spray Drying of Orthosiphon Staminues

The leaves of Orthosiphon Stamineus contained many useful bioactive compounds (flavonoid) that exhibit excellent therapeutic properties. However, the flavonoid contain is prone to degradation when expose to high temperature during spray drying to produce Orthosiphon Stamineus in powder form. Microen...

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Main Author:	Lee Siew, Ling
Format:	Undergraduates Project Papers
Language:	English
Published:	2013
Subjects:	RS Pharmacy and materia medica
Online Access:	http://umpir.ump.edu.my/id/eprint/7015/ http://umpir.ump.edu.my/id/eprint/7015/ http://umpir.ump.edu.my/id/eprint/7015/1/CD7363.pdf

id	ump-7015
recordtype	eprints
spelling	ump-70152015-03-03T09:33:52Z http://umpir.ump.edu.my/id/eprint/7015/ Microencapsulation and Spray Drying of Orthosiphon Staminues Lee Siew, Ling RS Pharmacy and materia medica The leaves of Orthosiphon Stamineus contained many useful bioactive compounds (flavonoid) that exhibit excellent therapeutic properties. However, the flavonoid contain is prone to degradation when expose to high temperature during spray drying to produce Orthosiphon Stamineus in powder form. Microencapsulation is one of the methods to preserve the flavonoids from degrading. This research is undertaken to achieve the objectives to minimize the thermal degradation of Orthosiphon Stamineus compound using spray drying method and microencapsulation method besides formulating a stable organically derived micorencapsulat to preserve the bioactive compounds from degrading. This research was conducted by extracting the bioactive compound from Orthosiphon Stamineus leaves using 70% methanol. Different concentration of the encapsulating agent, maltodextrin (MD) and whey protein isolate (WPI) were studied. The moisture, total solid and total flavonoid content test besides UPLC were analyzed. From the result obtained, 5% WPI added to the extract solution recorded the highest concentration of rosmarinic acid with amount 2.48 mg/ml and 0.00714 mg/ml. of sinensetin whereas 5% MD recorded high concentration of rosmarinic acid with amount 2.38 mg/ml and 0.00719 mg/ml sinensetin. However, 5% of WPI was a better encapsulating agent when compare to maltodextrin with its capability to achieve highest rosmarinic acid and sinensetin retention at 98.7% and 92.5% respectively. On the other hand, usage of 5% maltodextrin recorded lower rosmarinic retention (94.8%) and sinensetin (93.1%). Thus, minimize degradation of the useful bioactive components in Orthosiphon Stamineus were able to be prevented by applying the spray drying method using 5% microencapsulating agent whey protein isolate. 2013-02 Undergraduates Project Papers NonPeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/7015/1/CD7363.pdf Lee Siew, Ling (2013) Microencapsulation and Spray Drying of Orthosiphon Staminues. Faculty of Chemical and Natural Resources Engineering, Universiti Malaysia Pahang. http://iportal.ump.edu.my/lib/item?id=chamo:75759&theme=UMP2
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Lee Siew, Ling Microencapsulation and Spray Drying of Orthosiphon Staminues
description	The leaves of Orthosiphon Stamineus contained many useful bioactive compounds (flavonoid) that exhibit excellent therapeutic properties. However, the flavonoid contain is prone to degradation when expose to high temperature during spray drying to produce Orthosiphon Stamineus in powder form. Microencapsulation is one of the methods to preserve the flavonoids from degrading. This research is undertaken to achieve the objectives to minimize the thermal degradation of Orthosiphon Stamineus compound using spray drying method and microencapsulation method besides formulating a stable organically derived micorencapsulat to preserve the bioactive compounds from degrading. This research was conducted by extracting the bioactive compound from Orthosiphon Stamineus leaves using 70% methanol. Different concentration of the encapsulating agent, maltodextrin (MD) and whey protein isolate (WPI) were studied. The moisture, total solid and total flavonoid content test besides UPLC were analyzed. From the result obtained, 5% WPI added to the extract solution recorded the highest concentration of rosmarinic acid with amount 2.48 mg/ml and 0.00714 mg/ml. of sinensetin whereas 5% MD recorded high concentration of rosmarinic acid with amount 2.38 mg/ml and 0.00719 mg/ml sinensetin. However, 5% of WPI was a better encapsulating agent when compare to maltodextrin with its capability to achieve highest rosmarinic acid and sinensetin retention at 98.7% and 92.5% respectively. On the other hand, usage of 5% maltodextrin recorded lower rosmarinic retention (94.8%) and sinensetin (93.1%). Thus, minimize degradation of the useful bioactive components in Orthosiphon Stamineus were able to be prevented by applying the spray drying method using 5% microencapsulating agent whey protein isolate.
format	Undergraduates Project Papers
author	Lee Siew, Ling
author_facet	Lee Siew, Ling
author_sort	Lee Siew, Ling
title	Microencapsulation and Spray Drying of Orthosiphon Staminues
title_short	Microencapsulation and Spray Drying of Orthosiphon Staminues
title_full	Microencapsulation and Spray Drying of Orthosiphon Staminues
title_fullStr	Microencapsulation and Spray Drying of Orthosiphon Staminues
title_full_unstemmed	Microencapsulation and Spray Drying of Orthosiphon Staminues
title_sort	microencapsulation and spray drying of orthosiphon staminues
publishDate	2013
url	http://umpir.ump.edu.my/id/eprint/7015/ http://umpir.ump.edu.my/id/eprint/7015/ http://umpir.ump.edu.my/id/eprint/7015/1/CD7363.pdf
first_indexed	2023-09-18T22:03:15Z
last_indexed	2023-09-18T22:03:15Z
_version_	1777414539356143616

Microencapsulation and Spray Drying of Orthosiphon Staminues

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