Production of Lovastatin by Penicillium spp. Soil Microfungi

Lovastatin is an important fungal secondary metabolite inhibiting the enzyme which catalyzes a rate-limiting step in the biosynthesis of cholesterol. As microfungi of the genus Penicillium are active producers of cholesterol lowering agents (statins), studies of this genus have gained considerable...

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Main Authors:	Seydametova, Emine, Jailani, Salihon, N., Zainol, Convey, Peter
Format:	Article
Language:	English
Published:	IACSIT Press 2012
Subjects:	TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/6898/ http://umpir.ump.edu.my/id/eprint/6898/ http://umpir.ump.edu.my/id/eprint/6898/ http://umpir.ump.edu.my/id/eprint/6898/1/Production_of_Lovastatin_by_Penicillium_spp.pdf

id	ump-6898
recordtype	eprints
spelling	ump-68982018-01-15T04:31:15Z http://umpir.ump.edu.my/id/eprint/6898/ Production of Lovastatin by Penicillium spp. Soil Microfungi Seydametova, Emine Jailani, Salihon N., Zainol Convey, Peter TP Chemical technology Lovastatin is an important fungal secondary metabolite inhibiting the enzyme which catalyzes a rate-limiting step in the biosynthesis of cholesterol. As microfungi of the genus Penicillium are active producers of cholesterol lowering agents (statins), studies of this genus have gained considerable momentum. In Malaysia, both agricultural soils and those of natural ecosystems are valuable sources of filamentous fungi, whose biotechnological potential in terms of lovastatin production has not been well investigated. The aim of the present study is to determine lovastatin-producing potential of Penicillium spp. microfungi isolated from soil in Pahang State (Malaysia). Fungal cultures were isolated, purified, and classified based on characters of colony morphology and microscopic features. All identified representatives of Penicillium were tested for their ability to produce lovastatin. Isolates were cultivated in submerged fermentation. High-performance liquid chromatography (HPLC) was used for detection of lovastatin. Among 54 fungal cultures examined, four Penicillium strains were confirmed to produce this statin. The isolate Penicillium sp. ESF2M was the strongest lovastatin producer, with a yield of 20 mg/l. This strain should now be subjected to a further strain improvement program to maximize the yield of this important statin. IACSIT Press 2012 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/6898/1/Production_of_Lovastatin_by_Penicillium_spp.pdf Seydametova, Emine and Jailani, Salihon and N., Zainol and Convey, Peter (2012) Production of Lovastatin by Penicillium spp. Soil Microfungi. International Journal of Chemical Engineering and Applications (IJCEA), 3 (5). pp. 337-339. ISSN 2010-0221 http://www.ijcea.org/papers/213-E00016.pdf 10.7763/IJCEA.2012.V3.213
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Seydametova, Emine Jailani, Salihon N., Zainol Convey, Peter Production of Lovastatin by Penicillium spp. Soil Microfungi
description	Lovastatin is an important fungal secondary metabolite inhibiting the enzyme which catalyzes a rate-limiting step in the biosynthesis of cholesterol. As microfungi of the genus Penicillium are active producers of cholesterol lowering agents (statins), studies of this genus have gained considerable momentum. In Malaysia, both agricultural soils and those of natural ecosystems are valuable sources of filamentous fungi, whose biotechnological potential in terms of lovastatin production has not been well investigated. The aim of the present study is to determine lovastatin-producing potential of Penicillium spp. microfungi isolated from soil in Pahang State (Malaysia). Fungal cultures were isolated, purified, and classified based on characters of colony morphology and microscopic features. All identified representatives of Penicillium were tested for their ability to produce lovastatin. Isolates were cultivated in submerged fermentation. High-performance liquid chromatography (HPLC) was used for detection of lovastatin. Among 54 fungal cultures examined, four Penicillium strains were confirmed to produce this statin. The isolate Penicillium sp. ESF2M was the strongest lovastatin producer, with a yield of 20 mg/l. This strain should now be subjected to a further strain improvement program to maximize the yield of this important statin.
format	Article
author	Seydametova, Emine Jailani, Salihon N., Zainol Convey, Peter
author_facet	Seydametova, Emine Jailani, Salihon N., Zainol Convey, Peter
author_sort	Seydametova, Emine
title	Production of Lovastatin by Penicillium spp. Soil Microfungi
title_short	Production of Lovastatin by Penicillium spp. Soil Microfungi
title_full	Production of Lovastatin by Penicillium spp. Soil Microfungi
title_fullStr	Production of Lovastatin by Penicillium spp. Soil Microfungi
title_full_unstemmed	Production of Lovastatin by Penicillium spp. Soil Microfungi
title_sort	production of lovastatin by penicillium spp. soil microfungi
publisher	IACSIT Press
publishDate	2012
url	http://umpir.ump.edu.my/id/eprint/6898/ http://umpir.ump.edu.my/id/eprint/6898/ http://umpir.ump.edu.my/id/eprint/6898/ http://umpir.ump.edu.my/id/eprint/6898/1/Production_of_Lovastatin_by_Penicillium_spp.pdf
first_indexed	2023-09-18T22:03:05Z
last_indexed	2023-09-18T22:03:05Z
_version_	1777414528069271552

Production of Lovastatin by Penicillium spp. Soil Microfungi

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