A Hybrid of Harmony Search and Minimization of Metabolic Adjustment for Optimization of Succinic Acid Production

Succinic acid has been favored by researchers due to its industrial multi-uses. However, the production of succinic acid is far below cell theoretical maximum. The goal of this research is to identify the optimal set of gene knockouts for obtaining high production of succinic acid in microorganisms....

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Main Authors:	Nor Syahirah, Abdul Wahid, Mohd Saberi, Mohamad, Abdul Hakim, Mohamed Salleh, Safaai, Deris, Chan, Weng Howe, Omatu, Sigeru, Corchado, Juan Manuel, Muhammad Farhan, Sjaugi, Zuwairie, Ibrahim, Zulkifli, Md. Yusof
Format:	Book Section
Language:	English
Published:	Springer 2016
Subjects:	QH426 Genetics TJ Mechanical engineering and machinery
Online Access:	http://umpir.ump.edu.my/id/eprint/6822/ http://umpir.ump.edu.my/id/eprint/6822/ http://umpir.ump.edu.my/id/eprint/6822/ http://umpir.ump.edu.my/id/eprint/6822/1/Hybrid%20of%20Harmony%20Search%20and%20Minimization%20of%20Meta.pdf

id	ump-6822
recordtype	eprints
spelling	ump-68222018-02-08T02:50:41Z http://umpir.ump.edu.my/id/eprint/6822/ A Hybrid of Harmony Search and Minimization of Metabolic Adjustment for Optimization of Succinic Acid Production Nor Syahirah, Abdul Wahid Mohd Saberi, Mohamad Abdul Hakim, Mohamed Salleh Safaai, Deris Chan, Weng Howe Omatu, Sigeru Corchado, Juan Manuel Muhammad Farhan, Sjaugi Zuwairie, Ibrahim Zulkifli, Md. Yusof QH426 Genetics TJ Mechanical engineering and machinery Succinic acid has been favored by researchers due to its industrial multi-uses. However, the production of succinic acid is far below cell theoretical maximum. The goal of this research is to identify the optimal set of gene knockouts for obtaining high production of succinic acid in microorganisms. Gene knockout is a widely used genetic engineering technique. Hence, a hybrid of Harmony Search (HS) and Minimization of Metabolic Adjustment (MOMA) is proposed. The dataset applied is a core Escherichia coli metabolic network model. Harmony Search is a meta-heuristic algorithm inspired by musicians’ improvisation process. Minimization of Metabolic Adjustment is used to calculate fitness closest to the wild-type, after mutant gene knockout. The result obtained from the proposed hybrid technique are knockout genes list and production rate after the deletion. This proposed technique is possible to be applied in wet laboratory experiment to increase the production of succinic acid in E. coli. Springer Mohd Saberi, Mohamad Rocha, Miguel P. Fdez-Riverola, Florentino Mayo, Francisco J. Domínguez Paz, Juan F. De 2016 Book Section PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/6822/1/Hybrid%20of%20Harmony%20Search%20and%20Minimization%20of%20Meta.pdf Nor Syahirah, Abdul Wahid and Mohd Saberi, Mohamad and Abdul Hakim, Mohamed Salleh and Safaai, Deris and Chan, Weng Howe and Omatu, Sigeru and Corchado, Juan Manuel and Muhammad Farhan, Sjaugi and Zuwairie, Ibrahim and Zulkifli, Md. Yusof (2016) A Hybrid of Harmony Search and Minimization of Metabolic Adjustment for Optimization of Succinic Acid Production. In: 10th International Conference on Practical Applications of Computational Biology & Bioinformatics. Advances in Intelligent Systems and Computing, 477 (Pt. IV). Springer, Switzerland, pp. 183-191. ISBN 978-3-319-40125-6 (print); 978-3-319-40126-3 (online) http://dx.doi.org/10.1007/978-3-319-40126-3_19 DOI: 10.1007/978-3-319-40126-3_19
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	QH426 Genetics TJ Mechanical engineering and machinery
spellingShingle	QH426 Genetics TJ Mechanical engineering and machinery Nor Syahirah, Abdul Wahid Mohd Saberi, Mohamad Abdul Hakim, Mohamed Salleh Safaai, Deris Chan, Weng Howe Omatu, Sigeru Corchado, Juan Manuel Muhammad Farhan, Sjaugi Zuwairie, Ibrahim Zulkifli, Md. Yusof A Hybrid of Harmony Search and Minimization of Metabolic Adjustment for Optimization of Succinic Acid Production
description	Succinic acid has been favored by researchers due to its industrial multi-uses. However, the production of succinic acid is far below cell theoretical maximum. The goal of this research is to identify the optimal set of gene knockouts for obtaining high production of succinic acid in microorganisms. Gene knockout is a widely used genetic engineering technique. Hence, a hybrid of Harmony Search (HS) and Minimization of Metabolic Adjustment (MOMA) is proposed. The dataset applied is a core Escherichia coli metabolic network model. Harmony Search is a meta-heuristic algorithm inspired by musicians’ improvisation process. Minimization of Metabolic Adjustment is used to calculate fitness closest to the wild-type, after mutant gene knockout. The result obtained from the proposed hybrid technique are knockout genes list and production rate after the deletion. This proposed technique is possible to be applied in wet laboratory experiment to increase the production of succinic acid in E. coli.
author2	Mohd Saberi, Mohamad
author_facet	Mohd Saberi, Mohamad Nor Syahirah, Abdul Wahid Mohd Saberi, Mohamad Abdul Hakim, Mohamed Salleh Safaai, Deris Chan, Weng Howe Omatu, Sigeru Corchado, Juan Manuel Muhammad Farhan, Sjaugi Zuwairie, Ibrahim Zulkifli, Md. Yusof
format	Book Section
author	Nor Syahirah, Abdul Wahid Mohd Saberi, Mohamad Abdul Hakim, Mohamed Salleh Safaai, Deris Chan, Weng Howe Omatu, Sigeru Corchado, Juan Manuel Muhammad Farhan, Sjaugi Zuwairie, Ibrahim Zulkifli, Md. Yusof
author_sort	Nor Syahirah, Abdul Wahid
title	A Hybrid of Harmony Search and Minimization of Metabolic Adjustment for Optimization of Succinic Acid Production
title_short	A Hybrid of Harmony Search and Minimization of Metabolic Adjustment for Optimization of Succinic Acid Production
title_full	A Hybrid of Harmony Search and Minimization of Metabolic Adjustment for Optimization of Succinic Acid Production
title_fullStr	A Hybrid of Harmony Search and Minimization of Metabolic Adjustment for Optimization of Succinic Acid Production
title_full_unstemmed	A Hybrid of Harmony Search and Minimization of Metabolic Adjustment for Optimization of Succinic Acid Production
title_sort	hybrid of harmony search and minimization of metabolic adjustment for optimization of succinic acid production
publisher	Springer
publishDate	2016
url	http://umpir.ump.edu.my/id/eprint/6822/ http://umpir.ump.edu.my/id/eprint/6822/ http://umpir.ump.edu.my/id/eprint/6822/ http://umpir.ump.edu.my/id/eprint/6822/1/Hybrid%20of%20Harmony%20Search%20and%20Minimization%20of%20Meta.pdf
first_indexed	2023-09-18T22:02:56Z
last_indexed	2023-09-18T22:02:56Z
_version_	1777414519433199616

A Hybrid of Harmony Search and Minimization of Metabolic Adjustment for Optimization of Succinic Acid Production

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