Nanostructured Materials From Hydroxyethyl Cellulose For Skin Tissue Engineering

In this study, a novel fibrous membrane of hydroxyethyl cellulose (HEC)/poly(vinyl alcohol) blend was successfully fabricated by electrospinning technique and characterized. The concentration of HEC (5%) with PVA (15%) was optimized, blended in different ratios (30–50%) and electrospun to get smooth...

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Main Authors:	Farah Hanani, Zulkifli, Jahir Hussain, Fathima Shahitha, M. M., Yusoff, Mohammad Syaiful Bahari, Abdull Rasad
Format:	Article
Language:	English English
Published:	Elsevier Ltd 2014
Subjects:	Q Science (General) QD Chemistry
Online Access:	http://umpir.ump.edu.my/id/eprint/6597/ http://umpir.ump.edu.my/id/eprint/6597/ http://umpir.ump.edu.my/id/eprint/6597/ http://umpir.ump.edu.my/id/eprint/6597/1/Nanostructured%20Materials%20from%20Hydroxyethyl%20Cellulose%20for%20Skin%20Tissue%20Engineering.pdf http://umpir.ump.edu.my/id/eprint/6597/7/Nanostructured%20Materials%20From%20Hydroxyethyl%20Cellulose%20For%20Skin%20Tissue%20Engineering.pdf

id	ump-6597
recordtype	eprints
spelling	ump-65972018-07-26T06:55:01Z http://umpir.ump.edu.my/id/eprint/6597/ Nanostructured Materials From Hydroxyethyl Cellulose For Skin Tissue Engineering Farah Hanani, Zulkifli Jahir Hussain, Fathima Shahitha M. M., Yusoff Mohammad Syaiful Bahari, Abdull Rasad Q Science (General) QD Chemistry In this study, a novel fibrous membrane of hydroxyethyl cellulose (HEC)/poly(vinyl alcohol) blend was successfully fabricated by electrospinning technique and characterized. The concentration of HEC (5%) with PVA (15%) was optimized, blended in different ratios (30–50%) and electrospun to get smooth nanofibers. Nanofibrous membranes were made water insoluble by chemically cross-linking by glutaraldehyde and used as scaffolds for the skin tissue engineering. The microstructure, morphology, mechanical and thermal properties of the blended HEC/PVA nanofibrous scaffolds were characterized by scanning electron microscope, Fourier transform infrared spectroscopy, differential scanning colorimetry, universal testing machine and thermogravimetric analysis. Cytotoxicity studies on these nanofibrous scaffolds were carried out using human melanoma cells by the MTT assays. The cells were able to attach and spread in the nanofibrous scaffolds as shown by the SEM images. These preliminary results show that these nanofibrous scaffolds that supports cell adhesion and proliferation is promising for skin tissue engineering. Elsevier Ltd 2014 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/6597/1/Nanostructured%20Materials%20from%20Hydroxyethyl%20Cellulose%20for%20Skin%20Tissue%20Engineering.pdf application/pdf en http://umpir.ump.edu.my/id/eprint/6597/7/Nanostructured%20Materials%20From%20Hydroxyethyl%20Cellulose%20For%20Skin%20Tissue%20Engineering.pdf Farah Hanani, Zulkifli and Jahir Hussain, Fathima Shahitha and M. M., Yusoff and Mohammad Syaiful Bahari, Abdull Rasad (2014) Nanostructured Materials From Hydroxyethyl Cellulose For Skin Tissue Engineering. Carbohydrate Polymers, 114. pp. 238-245. ISSN 0144-8617 http://dx.doi.org/10.1016/j.carbpol.2014.08.019 DOI: 10.1016/j.carbpol.2014.08.019
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English English
topic	Q Science (General) QD Chemistry
spellingShingle	Q Science (General) QD Chemistry Farah Hanani, Zulkifli Jahir Hussain, Fathima Shahitha M. M., Yusoff Mohammad Syaiful Bahari, Abdull Rasad Nanostructured Materials From Hydroxyethyl Cellulose For Skin Tissue Engineering
description	In this study, a novel fibrous membrane of hydroxyethyl cellulose (HEC)/poly(vinyl alcohol) blend was successfully fabricated by electrospinning technique and characterized. The concentration of HEC (5%) with PVA (15%) was optimized, blended in different ratios (30–50%) and electrospun to get smooth nanofibers. Nanofibrous membranes were made water insoluble by chemically cross-linking by glutaraldehyde and used as scaffolds for the skin tissue engineering. The microstructure, morphology, mechanical and thermal properties of the blended HEC/PVA nanofibrous scaffolds were characterized by scanning electron microscope, Fourier transform infrared spectroscopy, differential scanning colorimetry, universal testing machine and thermogravimetric analysis. Cytotoxicity studies on these nanofibrous scaffolds were carried out using human melanoma cells by the MTT assays. The cells were able to attach and spread in the nanofibrous scaffolds as shown by the SEM images. These preliminary results show that these nanofibrous scaffolds that supports cell adhesion and proliferation is promising for skin tissue engineering.
format	Article
author	Farah Hanani, Zulkifli Jahir Hussain, Fathima Shahitha M. M., Yusoff Mohammad Syaiful Bahari, Abdull Rasad
author_facet	Farah Hanani, Zulkifli Jahir Hussain, Fathima Shahitha M. M., Yusoff Mohammad Syaiful Bahari, Abdull Rasad
author_sort	Farah Hanani, Zulkifli
title	Nanostructured Materials From Hydroxyethyl Cellulose For Skin Tissue Engineering
title_short	Nanostructured Materials From Hydroxyethyl Cellulose For Skin Tissue Engineering
title_full	Nanostructured Materials From Hydroxyethyl Cellulose For Skin Tissue Engineering
title_fullStr	Nanostructured Materials From Hydroxyethyl Cellulose For Skin Tissue Engineering
title_full_unstemmed	Nanostructured Materials From Hydroxyethyl Cellulose For Skin Tissue Engineering
title_sort	nanostructured materials from hydroxyethyl cellulose for skin tissue engineering
publisher	Elsevier Ltd
publishDate	2014
url	http://umpir.ump.edu.my/id/eprint/6597/ http://umpir.ump.edu.my/id/eprint/6597/ http://umpir.ump.edu.my/id/eprint/6597/ http://umpir.ump.edu.my/id/eprint/6597/1/Nanostructured%20Materials%20from%20Hydroxyethyl%20Cellulose%20for%20Skin%20Tissue%20Engineering.pdf http://umpir.ump.edu.my/id/eprint/6597/7/Nanostructured%20Materials%20From%20Hydroxyethyl%20Cellulose%20For%20Skin%20Tissue%20Engineering.pdf
first_indexed	2023-09-18T22:02:30Z
last_indexed	2023-09-18T22:02:30Z
_version_	1777414492145057792

Nanostructured Materials From Hydroxyethyl Cellulose For Skin Tissue Engineering

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