Growth Inhibitory Effect On Bacteria Of Swietenia Macrophylla King Seeds And Leaves Crude Alkaloid Extracts

The uses of plant-based products for disease prevention and treatment become increasingly popular in many societies. Plants are considered one of the major sources for many bioactive groups such as alkaloids. The purpose of this study was to determine the rate of alkaloids and investigate antibacter...

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Main Authors:	Azhari, H. Nour, M. M., Yusoff, Mohammed, S. B., Nour, A. H., Mazza, A. S.
Format:	Article
Language:	English English
Published:	IJPSR 2014
Subjects:	TP Chemical technology QD Chemistry
Online Access:	http://umpir.ump.edu.my/id/eprint/6453/ http://umpir.ump.edu.my/id/eprint/6453/ http://umpir.ump.edu.my/id/eprint/6453/ http://umpir.ump.edu.my/id/eprint/6453/1/Growth_Inhibitory_Effect_On_Bacteria_Of_Swietenia_Macrophylla_King_Seeds_And_Leaves_Crude_Alkaloid_Extracts.pdf http://umpir.ump.edu.my/id/eprint/6453/4/Growth%20Inhibitory%20Effect%20On%20Bacteria%20Of%20Swietenia%20Macrophylla%20King%20Seeds%20And%20Leaves%20Crude%20Alkaloid%20Extracts.pdf

id	ump-6453
recordtype	eprints
spelling	ump-64532018-03-08T06:10:24Z http://umpir.ump.edu.my/id/eprint/6453/ Growth Inhibitory Effect On Bacteria Of Swietenia Macrophylla King Seeds And Leaves Crude Alkaloid Extracts Azhari, H. Nour M. M., Yusoff Mohammed, S. B. Nour, A. H. Mazza, A. S. TP Chemical technology QD Chemistry The uses of plant-based products for disease prevention and treatment become increasingly popular in many societies. Plants are considered one of the major sources for many bioactive groups such as alkaloids. The purpose of this study was to determine the rate of alkaloids and investigate antibacterial activity of alkaloid fraction of seeds and leaves from plant, genus Swietenia of S. macrophylla (Familay: Maliaceae) against four pathogenic bacteria namely; Gram-positive: Staphylococcus aureus ATCC1026 and Gram-negative: Escherichia coli ATCC10536, Pseudomonas aeruginosa ATCC15442, and Salmonella typhimurium ATCC14038 based on inhibition zones. For the antibacterial bioassay, two concentrations, 50 and 100 mg/mL of seeds and leaves extracts were prepared and tested by disc diffusion method. The obtained results showed that the plant parts contain various levels of alkaloids, and with appreciable level of antibacterial activity against all tested microorganisms. The seeds extract showed high activity at a concentration of 100 mg/mL compared with leaves at the same concentration, especially against Gram-positive strain.The inhibition zones ranged from 3 to 21 mm for all treatments. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of the extracts ranged from 12.5 to 50 mg/mL. Furthermore, on TLC screening for phytochemicals groups, positive and interesting results were obtained, and the work underway to identify the bioactive compound(s). IJPSR 2014 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/6453/1/Growth_Inhibitory_Effect_On_Bacteria_Of_Swietenia_Macrophylla_King_Seeds_And_Leaves_Crude_Alkaloid_Extracts.pdf application/pdf en http://umpir.ump.edu.my/id/eprint/6453/4/Growth%20Inhibitory%20Effect%20On%20Bacteria%20Of%20Swietenia%20Macrophylla%20King%20Seeds%20And%20Leaves%20Crude%20Alkaloid%20Extracts.pdf Azhari, H. Nour and M. M., Yusoff and Mohammed, S. B. and Nour, A. H. and Mazza, A. S. (2014) Growth Inhibitory Effect On Bacteria Of Swietenia Macrophylla King Seeds And Leaves Crude Alkaloid Extracts. International Journal of Pharmaceutical Sciences and Research , 5 (8). pp. 3204-3208. ISSN 2320-5148 (print); 0975-8232 (online) http://www.ijpsr.com/V5I8/index.html DOI: 10.13040/IJPSR.0975-8232.5(8).3204-08
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English English
topic	TP Chemical technology QD Chemistry
spellingShingle	TP Chemical technology QD Chemistry Azhari, H. Nour M. M., Yusoff Mohammed, S. B. Nour, A. H. Mazza, A. S. Growth Inhibitory Effect On Bacteria Of Swietenia Macrophylla King Seeds And Leaves Crude Alkaloid Extracts
description	The uses of plant-based products for disease prevention and treatment become increasingly popular in many societies. Plants are considered one of the major sources for many bioactive groups such as alkaloids. The purpose of this study was to determine the rate of alkaloids and investigate antibacterial activity of alkaloid fraction of seeds and leaves from plant, genus Swietenia of S. macrophylla (Familay: Maliaceae) against four pathogenic bacteria namely; Gram-positive: Staphylococcus aureus ATCC1026 and Gram-negative: Escherichia coli ATCC10536, Pseudomonas aeruginosa ATCC15442, and Salmonella typhimurium ATCC14038 based on inhibition zones. For the antibacterial bioassay, two concentrations, 50 and 100 mg/mL of seeds and leaves extracts were prepared and tested by disc diffusion method. The obtained results showed that the plant parts contain various levels of alkaloids, and with appreciable level of antibacterial activity against all tested microorganisms. The seeds extract showed high activity at a concentration of 100 mg/mL compared with leaves at the same concentration, especially against Gram-positive strain.The inhibition zones ranged from 3 to 21 mm for all treatments. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of the extracts ranged from 12.5 to 50 mg/mL. Furthermore, on TLC screening for phytochemicals groups, positive and interesting results were obtained, and the work underway to identify the bioactive compound(s).
format	Article
author	Azhari, H. Nour M. M., Yusoff Mohammed, S. B. Nour, A. H. Mazza, A. S.
author_facet	Azhari, H. Nour M. M., Yusoff Mohammed, S. B. Nour, A. H. Mazza, A. S.
author_sort	Azhari, H. Nour
title	Growth Inhibitory Effect On Bacteria Of Swietenia Macrophylla King Seeds And Leaves Crude Alkaloid Extracts
title_short	Growth Inhibitory Effect On Bacteria Of Swietenia Macrophylla King Seeds And Leaves Crude Alkaloid Extracts
title_full	Growth Inhibitory Effect On Bacteria Of Swietenia Macrophylla King Seeds And Leaves Crude Alkaloid Extracts
title_fullStr	Growth Inhibitory Effect On Bacteria Of Swietenia Macrophylla King Seeds And Leaves Crude Alkaloid Extracts
title_full_unstemmed	Growth Inhibitory Effect On Bacteria Of Swietenia Macrophylla King Seeds And Leaves Crude Alkaloid Extracts
title_sort	growth inhibitory effect on bacteria of swietenia macrophylla king seeds and leaves crude alkaloid extracts
publisher	IJPSR
publishDate	2014
url	http://umpir.ump.edu.my/id/eprint/6453/ http://umpir.ump.edu.my/id/eprint/6453/ http://umpir.ump.edu.my/id/eprint/6453/ http://umpir.ump.edu.my/id/eprint/6453/1/Growth_Inhibitory_Effect_On_Bacteria_Of_Swietenia_Macrophylla_King_Seeds_And_Leaves_Crude_Alkaloid_Extracts.pdf http://umpir.ump.edu.my/id/eprint/6453/4/Growth%20Inhibitory%20Effect%20On%20Bacteria%20Of%20Swietenia%20Macrophylla%20King%20Seeds%20And%20Leaves%20Crude%20Alkaloid%20Extracts.pdf
first_indexed	2023-09-18T22:02:12Z
last_indexed	2023-09-18T22:02:12Z
_version_	1777414473056780288

Growth Inhibitory Effect On Bacteria Of Swietenia Macrophylla King Seeds And Leaves Crude Alkaloid Extracts

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