Product Optimization of a Fed-batch Fermentation Process

This paper discusses the development of constrained optimization strategies for a fed- batch penicillin fermentation process. To facilitate the study, a mathematical model of the system is developed based on published materials, and simulated using MATLAB software. Good agreement is obtained when t...

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Main Authors:	Noor Asma Fazli, Abdul Samad, Arshad, Ahmad, Mohd Kamaruddin, Abd Hamid
Format:	Conference or Workshop Item
Language:	English
Published:	2007
Subjects:	TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/6218/ http://umpir.ump.edu.my/id/eprint/6218/1/fkksa-2007_proceeding.pdf

id	ump-6218
recordtype	eprints
spelling	ump-62182018-05-04T07:59:19Z http://umpir.ump.edu.my/id/eprint/6218/ Product Optimization of a Fed-batch Fermentation Process Noor Asma Fazli, Abdul Samad Arshad, Ahmad Mohd Kamaruddin, Abd Hamid TP Chemical technology This paper discusses the development of constrained optimization strategies for a fed- batch penicillin fermentation process. To facilitate the study, a mathematical model of the system is developed based on published materials, and simulated using MATLAB software. Good agreement is obtained when the results are validated against published work. To provide on-line estimates of the difficult to measure penicillin concentration, Partial Least Squares model is employed. Using these estimates, good control of product concentration is established thus enabling it to be implemented as part of product concentration control loop. Further improvements are introduced using dynamic optimization aiming at increasing the achievable product concentration while satisfying all process constraints. Two strategies are considered. These are optimal control policy using direct-shooting algorithm and unconstrained Dynamic Matrix Control (DMC). From this two optimization approaches, it is possible to estimate the optimal operating conditions as substrate feed rate so that the systems presents high performance within threshold value limit. The result also revealed that the use of DMC approach is superior the direct shooting method in term of the penicillin concentration as well as penicillin purity. Results obtained in this study have exposed the potentials of dynamic optimization schemes in improving the product purity in a fed-batch fermentation process. 2007 Conference or Workshop Item PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/6218/1/fkksa-2007_proceeding.pdf Noor Asma Fazli, Abdul Samad and Arshad, Ahmad and Mohd Kamaruddin, Abd Hamid (2007) Product Optimization of a Fed-batch Fermentation Process. In: Proceedings of European Congress of Chemical Engineering (ECCE-6) , 16-20 September 2007 , Copenhagen. pp. 1-17..
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Noor Asma Fazli, Abdul Samad Arshad, Ahmad Mohd Kamaruddin, Abd Hamid Product Optimization of a Fed-batch Fermentation Process
description	This paper discusses the development of constrained optimization strategies for a fed- batch penicillin fermentation process. To facilitate the study, a mathematical model of the system is developed based on published materials, and simulated using MATLAB software. Good agreement is obtained when the results are validated against published work. To provide on-line estimates of the difficult to measure penicillin concentration, Partial Least Squares model is employed. Using these estimates, good control of product concentration is established thus enabling it to be implemented as part of product concentration control loop. Further improvements are introduced using dynamic optimization aiming at increasing the achievable product concentration while satisfying all process constraints. Two strategies are considered. These are optimal control policy using direct-shooting algorithm and unconstrained Dynamic Matrix Control (DMC). From this two optimization approaches, it is possible to estimate the optimal operating conditions as substrate feed rate so that the systems presents high performance within threshold value limit. The result also revealed that the use of DMC approach is superior the direct shooting method in term of the penicillin concentration as well as penicillin purity. Results obtained in this study have exposed the potentials of dynamic optimization schemes in improving the product purity in a fed-batch fermentation process.
format	Conference or Workshop Item
author	Noor Asma Fazli, Abdul Samad Arshad, Ahmad Mohd Kamaruddin, Abd Hamid
author_facet	Noor Asma Fazli, Abdul Samad Arshad, Ahmad Mohd Kamaruddin, Abd Hamid
author_sort	Noor Asma Fazli, Abdul Samad
title	Product Optimization of a Fed-batch Fermentation Process
title_short	Product Optimization of a Fed-batch Fermentation Process
title_full	Product Optimization of a Fed-batch Fermentation Process
title_fullStr	Product Optimization of a Fed-batch Fermentation Process
title_full_unstemmed	Product Optimization of a Fed-batch Fermentation Process
title_sort	product optimization of a fed-batch fermentation process
publishDate	2007
url	http://umpir.ump.edu.my/id/eprint/6218/ http://umpir.ump.edu.my/id/eprint/6218/1/fkksa-2007_proceeding.pdf
first_indexed	2023-09-18T22:01:48Z
last_indexed	2023-09-18T22:01:48Z
_version_	1777414448092282880

Product Optimization of a Fed-batch Fermentation Process

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