Anti-hyperalgesic Effect of a Benzilidine-cyclohexanone Analogue on a Mouse Model of Chronic Constriction Injury-induced Neuropathic Pain: Participation of the Îº-opioid Receptor and KATP

The present study investigated the analgesic effect of a novel synthetic cyclohexanone derivative, 2,6-bis-4-(hydroxyl-3-methoxybenzilidine)-cyclohexanone or BHMC in a mouse model of chronic constriction injury-induced neuropathic pain. It was demonstrated that intraperitoneal administration of BHMC...

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Main Authors:	Akhtar, Muhammad Nadeem, Shaik Ibrahim, Khalivulla, Lee, Ming-Tatt, Nordin, Lajis, Enoch Kumar, Perimal, Ahmad, Akira, Daud Israf, Ali, Mohd Roslan, Sulaiman
Format:	Article
Language:	English
Published:	Elsevier 2013
Subjects:	QR Microbiology
Online Access:	http://umpir.ump.edu.my/id/eprint/5245/ http://umpir.ump.edu.my/id/eprint/5245/ http://umpir.ump.edu.my/id/eprint/5245/ http://umpir.ump.edu.my/id/eprint/5245/1/fist-2013-nadeem-artAnti-HyperalgesicEffect.pdf

id	ump-5245
recordtype	eprints
spelling	ump-52452018-04-19T00:56:00Z http://umpir.ump.edu.my/id/eprint/5245/ Anti-hyperalgesic Effect of a Benzilidine-cyclohexanone Analogue on a Mouse Model of Chronic Constriction Injury-induced Neuropathic Pain: Participation of the Îº-opioid Receptor and KATP Akhtar, Muhammad Nadeem Shaik Ibrahim, Khalivulla Lee, Ming-Tatt Nordin, Lajis Enoch Kumar, Perimal Ahmad, Akira Daud Israf, Ali Mohd Roslan, Sulaiman QR Microbiology The present study investigated the analgesic effect of a novel synthetic cyclohexanone derivative, 2,6-bis-4-(hydroxyl-3-methoxybenzilidine)-cyclohexanone or BHMC in a mouse model of chronic constriction injury-induced neuropathic pain. It was demonstrated that intraperitoneal administration of BHMC (0.03, 0.1, 0.3 and 1.0 mg/kg) exhibited dose-dependent inhibition of chronic constriction injury-induced neuropathic pain in mice, when evaluated using RandallâSelitto mechanical analgesiometer. It was also demonstrated that pretreatment of naloxone (non-selective opioid receptor blocker), nor-binaltorphimine (nor-BNI, selective Îº-opioid receptor blocker), but not Î²-funaltrexamine (Î²-FN, selective Î¼-opioid receptor blocker) and naltrindole hydrochloride (NTI, selective Î´-opioid receptor blocker), reversed the anti-nociceptive effect of BHMC. In addition, the analgesic effect of BHMC was also reverted by pretreatment of 1H-[1,2,4]Oxadiazole[4,3-a]quinoxalin-1-one (ODQ, soluble guanosyl cyclase blocker) and glibenclamide (ATP-sensitive potassium channel blocker) but not NÏ-nitro-l-arginine (l-NAME, a nitric oxide synthase blocker). Taken together, the present study demonstrated that the systemic administration of BHMC attenuated chronic constriction, injury-induced neuropathic pain. We also suggested that the possible mechanisms include Îº-opioid receptor activation and nitric oxide-independent cyclic guanosine monophosphate activation of ATP-sensitive potassium channel opening. Elsevier 2013 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/5245/1/fist-2013-nadeem-artAnti-HyperalgesicEffect.pdf Akhtar, Muhammad Nadeem and Shaik Ibrahim, Khalivulla and Lee, Ming-Tatt and Nordin, Lajis and Enoch Kumar, Perimal and Ahmad, Akira and Daud Israf, Ali and Mohd Roslan, Sulaiman (2013) Anti-hyperalgesic Effect of a Benzilidine-cyclohexanone Analogue on a Mouse Model of Chronic Constriction Injury-induced Neuropathic Pain: Participation of the Îº-opioid Receptor and KATP. Pharmacology Biochemistry and Behavior, 114-115. pp. 58-63. ISSN 0091-3057 (print); 1873-5177 (online) http://dx.doi.org/10.1016/j.pbb.2013.10.019 DOI: 10.1016/j.pbb.2013.10.019
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	QR Microbiology
spellingShingle	QR Microbiology Akhtar, Muhammad Nadeem Shaik Ibrahim, Khalivulla Lee, Ming-Tatt Nordin, Lajis Enoch Kumar, Perimal Ahmad, Akira Daud Israf, Ali Mohd Roslan, Sulaiman Anti-hyperalgesic Effect of a Benzilidine-cyclohexanone Analogue on a Mouse Model of Chronic Constriction Injury-induced Neuropathic Pain: Participation of the Îº-opioid Receptor and KATP
description	The present study investigated the analgesic effect of a novel synthetic cyclohexanone derivative, 2,6-bis-4-(hydroxyl-3-methoxybenzilidine)-cyclohexanone or BHMC in a mouse model of chronic constriction injury-induced neuropathic pain. It was demonstrated that intraperitoneal administration of BHMC (0.03, 0.1, 0.3 and 1.0 mg/kg) exhibited dose-dependent inhibition of chronic constriction injury-induced neuropathic pain in mice, when evaluated using RandallâSelitto mechanical analgesiometer. It was also demonstrated that pretreatment of naloxone (non-selective opioid receptor blocker), nor-binaltorphimine (nor-BNI, selective Îº-opioid receptor blocker), but not Î²-funaltrexamine (Î²-FN, selective Î¼-opioid receptor blocker) and naltrindole hydrochloride (NTI, selective Î´-opioid receptor blocker), reversed the anti-nociceptive effect of BHMC. In addition, the analgesic effect of BHMC was also reverted by pretreatment of 1H-[1,2,4]Oxadiazole[4,3-a]quinoxalin-1-one (ODQ, soluble guanosyl cyclase blocker) and glibenclamide (ATP-sensitive potassium channel blocker) but not NÏ-nitro-l-arginine (l-NAME, a nitric oxide synthase blocker). Taken together, the present study demonstrated that the systemic administration of BHMC attenuated chronic constriction, injury-induced neuropathic pain. We also suggested that the possible mechanisms include Îº-opioid receptor activation and nitric oxide-independent cyclic guanosine monophosphate activation of ATP-sensitive potassium channel opening.
format	Article
author	Akhtar, Muhammad Nadeem Shaik Ibrahim, Khalivulla Lee, Ming-Tatt Nordin, Lajis Enoch Kumar, Perimal Ahmad, Akira Daud Israf, Ali Mohd Roslan, Sulaiman
author_facet	Akhtar, Muhammad Nadeem Shaik Ibrahim, Khalivulla Lee, Ming-Tatt Nordin, Lajis Enoch Kumar, Perimal Ahmad, Akira Daud Israf, Ali Mohd Roslan, Sulaiman
author_sort	Akhtar, Muhammad Nadeem
title	Anti-hyperalgesic Effect of a Benzilidine-cyclohexanone Analogue on a Mouse Model of Chronic Constriction Injury-induced Neuropathic Pain: Participation of the Îº-opioid Receptor and KATP
title_short	Anti-hyperalgesic Effect of a Benzilidine-cyclohexanone Analogue on a Mouse Model of Chronic Constriction Injury-induced Neuropathic Pain: Participation of the Îº-opioid Receptor and KATP
title_full	Anti-hyperalgesic Effect of a Benzilidine-cyclohexanone Analogue on a Mouse Model of Chronic Constriction Injury-induced Neuropathic Pain: Participation of the Îº-opioid Receptor and KATP
title_fullStr	Anti-hyperalgesic Effect of a Benzilidine-cyclohexanone Analogue on a Mouse Model of Chronic Constriction Injury-induced Neuropathic Pain: Participation of the Îº-opioid Receptor and KATP
title_full_unstemmed	Anti-hyperalgesic Effect of a Benzilidine-cyclohexanone Analogue on a Mouse Model of Chronic Constriction Injury-induced Neuropathic Pain: Participation of the Îº-opioid Receptor and KATP
title_sort	anti-hyperalgesic effect of a benzilidine-cyclohexanone analogue on a mouse model of chronic constriction injury-induced neuropathic pain: participation of the îº-opioid receptor and katp
publisher	Elsevier
publishDate	2013
url	http://umpir.ump.edu.my/id/eprint/5245/ http://umpir.ump.edu.my/id/eprint/5245/ http://umpir.ump.edu.my/id/eprint/5245/ http://umpir.ump.edu.my/id/eprint/5245/1/fist-2013-nadeem-artAnti-HyperalgesicEffect.pdf
first_indexed	2023-09-18T22:00:30Z
last_indexed	2023-09-18T22:00:30Z
_version_	1777414365945790464

Anti-hyperalgesic Effect of a Benzilidine-cyclohexanone Analogue on a Mouse Model of Chronic Constriction Injury-induced Neuropathic Pain: Participation of the Îº-opioid Receptor and KATP

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