Participation of Large Ca2+ Activated Potassium Channel in Antinociceptive Activity of Chalcone Derivative (3-(2, 5-dimethoxyphenyl)-1-(5-methylfuran-2-yl) prop-2-en-1-one) DMPF-1 Action in Mice Model

Participation of Large Ca2+ Activated Potassium Channel in Antinociceptive Activity of Chalcone Derivative (3-(2, 5-dimethoxyphenyl)-1-(5-methylfuran-2-yl) prop-2-en-1-one) DMPF-1 Action in Mice Model

The role of potassium channels in nociceptive activity was proposed in the past decade. Various type of potassium channel has been found to exert different action in propogation of action potential in nervous system. As DMPF-1, a chalcone derivative possesses antinociceptive properties. The mechani...

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Main Authors: Akhtar, Muhammad Nadeem, Noor Azlina, Abu Bakar, Mohd Roslan, Sulaiman, Nordin, Lajis, Akira Omar, Farouk
Format: Conference or Workshop Item
Language:English
Published: 2013
Subjects:
QR Microbiology
Online Access:http://umpir.ump.edu.my/id/eprint/5213/
http://umpir.ump.edu.my/id/eprint/5213/
http://umpir.ump.edu.my/id/eprint/5213/1/fist-2013-nadeem-confParticipationofLargeCa.pdf
id ump-5213
recordtype eprints
spelling ump-52132018-04-19T00:59:00Z http://umpir.ump.edu.my/id/eprint/5213/ Participation of Large Ca2+ Activated Potassium Channel in Antinociceptive Activity of Chalcone Derivative (3-(2, 5-dimethoxyphenyl)-1-(5-methylfuran-2-yl) prop-2-en-1-one) DMPF-1 Action in Mice Model Akhtar, Muhammad Nadeem Noor Azlina, Abu Bakar Mohd Roslan, Sulaiman Nordin, Lajis Akira Omar, Farouk QR Microbiology The role of potassium channels in nociceptive activity was proposed in the past decade. Various type of potassium channel has been found to exert different action in propogation of action potential in nervous system. As DMPF-1, a chalcone derivative possesses antinociceptive properties. The mechanism of its action has been carried out to verify the pathway involved. The present study addressed the role of potassium channel in the contribution of the antinociceptive action of DMPF-1. The involvement of potassium channel was evaluated using acetic acid-induced abdominal writhing test.The animals were pretreated with charybdotoxin (large Ca2+ activated potassium channel blocker)(0.04mg/kg, i.p) or apamin (small Ca2+ activated potassium channel blocker)(0.02mg/kg, i.p.) 15 minutes before administration of DMPF-1. It was demonstrated that the challenge of DMPF-1 treated group with charybdotoxin has reversed the antinociceptive activity of this novel chalcone, which indicates the possible participation of large Ca2+ activated potassium channel in antinociceptive effect cause by DMPF-1 but not through small Ca2+ activated potassium channel. 2013 Conference or Workshop Item PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/5213/1/fist-2013-nadeem-confParticipationofLargeCa.pdf Akhtar, Muhammad Nadeem and Noor Azlina, Abu Bakar and Mohd Roslan, Sulaiman and Nordin, Lajis and Akira Omar, Farouk (2013) Participation of Large Ca2+ Activated Potassium Channel in Antinociceptive Activity of Chalcone Derivative (3-(2, 5-dimethoxyphenyl)-1-(5-methylfuran-2-yl) prop-2-en-1-one) DMPF-1 Action in Mice Model. In: 3rd International Conference on Medical, Biological and Pharmaceutical Sciences (ICMBPS'2013), 4-5 January 2013 , Bali, Indonesia. pp. 204-206.. http://psrcentre.org/images/extraimages/42.%20113109.pdf
repository_type Digital Repository
institution_category Local University
institution Universiti Malaysia Pahang
building UMP Institutional Repository
collection Online Access
language English
topic QR Microbiology
spellingShingle QR Microbiology
Akhtar, Muhammad Nadeem
Noor Azlina, Abu Bakar
Mohd Roslan, Sulaiman
Nordin, Lajis
Akira Omar, Farouk
Participation of Large Ca2+ Activated Potassium Channel in Antinociceptive Activity of Chalcone Derivative (3-(2, 5-dimethoxyphenyl)-1-(5-methylfuran-2-yl) prop-2-en-1-one) DMPF-1 Action in Mice Model
description The role of potassium channels in nociceptive activity was proposed in the past decade. Various type of potassium channel has been found to exert different action in propogation of action potential in nervous system. As DMPF-1, a chalcone derivative possesses antinociceptive properties. The mechanism of its action has been carried out to verify the pathway involved. The present study addressed the role of potassium channel in the contribution of the antinociceptive action of DMPF-1. The involvement of potassium channel was evaluated using acetic acid-induced abdominal writhing test.The animals were pretreated with charybdotoxin (large Ca2+ activated potassium channel blocker)(0.04mg/kg, i.p) or apamin (small Ca2+ activated potassium channel blocker)(0.02mg/kg, i.p.) 15 minutes before administration of DMPF-1. It was demonstrated that the challenge of DMPF-1 treated group with charybdotoxin has reversed the antinociceptive activity of this novel chalcone, which indicates the possible participation of large Ca2+ activated potassium channel in antinociceptive effect cause by DMPF-1 but not through small Ca2+ activated potassium channel.
format Conference or Workshop Item
author Akhtar, Muhammad Nadeem
Noor Azlina, Abu Bakar
Mohd Roslan, Sulaiman
Nordin, Lajis
Akira Omar, Farouk
author_facet Akhtar, Muhammad Nadeem
Noor Azlina, Abu Bakar
Mohd Roslan, Sulaiman
Nordin, Lajis
Akira Omar, Farouk
author_sort Akhtar, Muhammad Nadeem
title Participation of Large Ca2+ Activated Potassium Channel in Antinociceptive Activity of Chalcone Derivative (3-(2, 5-dimethoxyphenyl)-1-(5-methylfuran-2-yl) prop-2-en-1-one) DMPF-1 Action in Mice Model
title_short Participation of Large Ca2+ Activated Potassium Channel in Antinociceptive Activity of Chalcone Derivative (3-(2, 5-dimethoxyphenyl)-1-(5-methylfuran-2-yl) prop-2-en-1-one) DMPF-1 Action in Mice Model
title_full Participation of Large Ca2+ Activated Potassium Channel in Antinociceptive Activity of Chalcone Derivative (3-(2, 5-dimethoxyphenyl)-1-(5-methylfuran-2-yl) prop-2-en-1-one) DMPF-1 Action in Mice Model
title_fullStr Participation of Large Ca2+ Activated Potassium Channel in Antinociceptive Activity of Chalcone Derivative (3-(2, 5-dimethoxyphenyl)-1-(5-methylfuran-2-yl) prop-2-en-1-one) DMPF-1 Action in Mice Model
title_full_unstemmed Participation of Large Ca2+ Activated Potassium Channel in Antinociceptive Activity of Chalcone Derivative (3-(2, 5-dimethoxyphenyl)-1-(5-methylfuran-2-yl) prop-2-en-1-one) DMPF-1 Action in Mice Model
title_sort participation of large ca2+ activated potassium channel in antinociceptive activity of chalcone derivative (3-(2, 5-dimethoxyphenyl)-1-(5-methylfuran-2-yl) prop-2-en-1-one) dmpf-1 action in mice model
publishDate 2013
url http://umpir.ump.edu.my/id/eprint/5213/
http://umpir.ump.edu.my/id/eprint/5213/
http://umpir.ump.edu.my/id/eprint/5213/1/fist-2013-nadeem-confParticipationofLargeCa.pdf
first_indexed 2023-09-18T22:00:29Z
last_indexed 2023-09-18T22:00:29Z
_version_ 1777414364641361920

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