Optimization of statin (Simvastatin) by monascus Purpureus FTC 5356 in solid-state fermentation

Monascus sp. is a non-pathogenic fungus that can produce statin called simvastatin that can lower blood cholesterol in human body. The objective of this research is to investigate the optimization condition of the simvastatin production in solid-state fermentation by Monascus purpureus FTC 5356. The...

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Main Author:	Morina, Mohd Selih
Format:	Undergraduates Project Papers
Language:	English
Published:	2012
Subjects:	TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/3619/ http://umpir.ump.edu.my/id/eprint/3619/ http://umpir.ump.edu.my/id/eprint/3619/1/CD6360_MORINA_MOHD_SELIH.pdf

id	ump-3619
recordtype	eprints
spelling	ump-36192015-03-03T08:02:11Z http://umpir.ump.edu.my/id/eprint/3619/ Optimization of statin (Simvastatin) by monascus Purpureus FTC 5356 in solid-state fermentation Morina, Mohd Selih TP Chemical technology Monascus sp. is a non-pathogenic fungus that can produce statin called simvastatin that can lower blood cholesterol in human body. The objective of this research is to investigate the optimization condition of the simvastatin production in solid-state fermentation by Monascus purpureus FTC 5356. The local products that used as substrates were banana, guava, pumpkin, coconut meat, corn, papaya and white rice. The fermentation was conducted using the optimum condition of 50% initial moisture content, pH6 at 30°C for 12 days in order to obtain the best substrate. Among these local products, corn can produce the simvastatin while other five fruits do not produce simvastatin. Further experimental carried out using Central Composite Design (CCD) of Response Surface Methodology (RSM) by setting two parameters which are moisture content and nitrogen source by setting the lower and higher range for each of the parameters. From the analysis from RSM, there are 14 runs conducted to achieve the optimum condition to get the maximum production of simvasatin. 2012-03 Undergraduates Project Papers NonPeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/3619/1/CD6360_MORINA_MOHD_SELIH.pdf Morina, Mohd Selih (2012) Optimization of statin (Simvastatin) by monascus Purpureus FTC 5356 in solid-state fermentation. Faculty of Chemical Engineering and Natural Resources, Universiti Malaysia Pahang. http://iportal.ump.edu.my/lib/item?id=chamo:66809&theme=UMP2
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Morina, Mohd Selih Optimization of statin (Simvastatin) by monascus Purpureus FTC 5356 in solid-state fermentation
description	Monascus sp. is a non-pathogenic fungus that can produce statin called simvastatin that can lower blood cholesterol in human body. The objective of this research is to investigate the optimization condition of the simvastatin production in solid-state fermentation by Monascus purpureus FTC 5356. The local products that used as substrates were banana, guava, pumpkin, coconut meat, corn, papaya and white rice. The fermentation was conducted using the optimum condition of 50% initial moisture content, pH6 at 30°C for 12 days in order to obtain the best substrate. Among these local products, corn can produce the simvastatin while other five fruits do not produce simvastatin. Further experimental carried out using Central Composite Design (CCD) of Response Surface Methodology (RSM) by setting two parameters which are moisture content and nitrogen source by setting the lower and higher range for each of the parameters. From the analysis from RSM, there are 14 runs conducted to achieve the optimum condition to get the maximum production of simvasatin.
format	Undergraduates Project Papers
author	Morina, Mohd Selih
author_facet	Morina, Mohd Selih
author_sort	Morina, Mohd Selih
title	Optimization of statin (Simvastatin) by monascus Purpureus FTC 5356 in solid-state fermentation
title_short	Optimization of statin (Simvastatin) by monascus Purpureus FTC 5356 in solid-state fermentation
title_full	Optimization of statin (Simvastatin) by monascus Purpureus FTC 5356 in solid-state fermentation
title_fullStr	Optimization of statin (Simvastatin) by monascus Purpureus FTC 5356 in solid-state fermentation
title_full_unstemmed	Optimization of statin (Simvastatin) by monascus Purpureus FTC 5356 in solid-state fermentation
title_sort	optimization of statin (simvastatin) by monascus purpureus ftc 5356 in solid-state fermentation
publishDate	2012
url	http://umpir.ump.edu.my/id/eprint/3619/ http://umpir.ump.edu.my/id/eprint/3619/ http://umpir.ump.edu.my/id/eprint/3619/1/CD6360_MORINA_MOHD_SELIH.pdf
first_indexed	2023-09-18T21:58:01Z
last_indexed	2023-09-18T21:58:01Z
_version_	1777414209867350016

Optimization of statin (Simvastatin) by monascus Purpureus FTC 5356 in solid-state fermentation

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