Recent advances in nanotheranostics for triple negative breast cancer treatment

Triple-negative breast cancer (TNBC) is the most complex and aggressive type of breast cancer encountered world widely in women. Absence of hormonal receptors on breast cancer cells necessitates the chemotherapy as the only treatment regime. High propensity to metastasize and relapse in addition to...

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Main Authors:	Thakur, Vikram, Rajaletchumy, Veloo Kutty
Format:	Article
Language:	English
Published:	BioMed Central Ltd. 2019
Subjects:	R Medicine (General) RC0254 Neoplasms. Tumors. Oncology (including Cancer) TA Engineering (General). Civil engineering (General)
Online Access:	http://umpir.ump.edu.my/id/eprint/26625/ http://umpir.ump.edu.my/id/eprint/26625/ http://umpir.ump.edu.my/id/eprint/26625/ http://umpir.ump.edu.my/id/eprint/26625/1/Recent%20advances%20in%20nanotheranostics%20for%20triple%20negative%20breast.pdf

id	ump-26625
recordtype	eprints
spelling	ump-266252019-12-10T02:49:17Z http://umpir.ump.edu.my/id/eprint/26625/ Recent advances in nanotheranostics for triple negative breast cancer treatment Thakur, Vikram Rajaletchumy, Veloo Kutty R Medicine (General) RC0254 Neoplasms. Tumors. Oncology (including Cancer) TA Engineering (General). Civil engineering (General) Triple-negative breast cancer (TNBC) is the most complex and aggressive type of breast cancer encountered world widely in women. Absence of hormonal receptors on breast cancer cells necessitates the chemotherapy as the only treatment regime. High propensity to metastasize and relapse in addition to poor prognosis and survival motivated the oncologist, nano-medical scientist to develop novel and efficient nanotherapies to solve such a big TNBC challenge. Recently, the focus for enhanced availability, targeted cellular uptake with minimal toxicity is achieved by nano-carriers. These smart nano-carriers carrying all the necessary arsenals (drugs, tracking probe, and ligand) designed in such a way that specifically targets the TNBC cells at site. Articulating the targeted delivery system with multifunctional molecules for high specificity, tracking, diagnosis, and treatment emerged as theranostic approach. In this review, in addition to classical treatment modalities, recent advances in nanotheranostics for early and effective diagnostic and treatment is discussed. This review highlighted the recently FDA approved immunotherapy and all the ongoing clinical trials for TNBC, in addition to nanoparticle assisted immunotherapy. Futuristic but realistic advancements in artificial intelligence (AI) and machine learning not only improve early diagnosis but also assist clinicians for their workup in TNBC. The novel concept of Nanoparticles induced endothelial leakiness (NanoEL) as a way of tumor invasion is also discussed in addition to classical EPR effect. This review intends to provide basic insight and understanding of the novel nano-therapeutic modalities in TNBC diagnosis and treatment and to sensitize the readers for continue designing the novel nanomedicine. This is the first time that designing nanoparticles with stoichiometric definable number of antibodies per nanoparticle now represents the next level of precision by design in nanomedicine. BioMed Central Ltd. 2019-10-28 Article PeerReviewed pdf en cc_by_4 http://umpir.ump.edu.my/id/eprint/26625/1/Recent%20advances%20in%20nanotheranostics%20for%20triple%20negative%20breast.pdf Thakur, Vikram and Rajaletchumy, Veloo Kutty (2019) Recent advances in nanotheranostics for triple negative breast cancer treatment. Journal of Experimental and Clinical Cancer Research, 38 (1). pp. 1-22. ISSN 1756-9966 https://doi.org/10.1186/s13046-019-1443-1 https://doi.org/10.1186/s13046-019-1443-1
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	R Medicine (General) RC0254 Neoplasms. Tumors. Oncology (including Cancer) TA Engineering (General). Civil engineering (General)
spellingShingle	R Medicine (General) RC0254 Neoplasms. Tumors. Oncology (including Cancer) TA Engineering (General). Civil engineering (General) Thakur, Vikram Rajaletchumy, Veloo Kutty Recent advances in nanotheranostics for triple negative breast cancer treatment
description	Triple-negative breast cancer (TNBC) is the most complex and aggressive type of breast cancer encountered world widely in women. Absence of hormonal receptors on breast cancer cells necessitates the chemotherapy as the only treatment regime. High propensity to metastasize and relapse in addition to poor prognosis and survival motivated the oncologist, nano-medical scientist to develop novel and efficient nanotherapies to solve such a big TNBC challenge. Recently, the focus for enhanced availability, targeted cellular uptake with minimal toxicity is achieved by nano-carriers. These smart nano-carriers carrying all the necessary arsenals (drugs, tracking probe, and ligand) designed in such a way that specifically targets the TNBC cells at site. Articulating the targeted delivery system with multifunctional molecules for high specificity, tracking, diagnosis, and treatment emerged as theranostic approach. In this review, in addition to classical treatment modalities, recent advances in nanotheranostics for early and effective diagnostic and treatment is discussed. This review highlighted the recently FDA approved immunotherapy and all the ongoing clinical trials for TNBC, in addition to nanoparticle assisted immunotherapy. Futuristic but realistic advancements in artificial intelligence (AI) and machine learning not only improve early diagnosis but also assist clinicians for their workup in TNBC. The novel concept of Nanoparticles induced endothelial leakiness (NanoEL) as a way of tumor invasion is also discussed in addition to classical EPR effect. This review intends to provide basic insight and understanding of the novel nano-therapeutic modalities in TNBC diagnosis and treatment and to sensitize the readers for continue designing the novel nanomedicine. This is the first time that designing nanoparticles with stoichiometric definable number of antibodies per nanoparticle now represents the next level of precision by design in nanomedicine.
format	Article
author	Thakur, Vikram Rajaletchumy, Veloo Kutty
author_facet	Thakur, Vikram Rajaletchumy, Veloo Kutty
author_sort	Thakur, Vikram
title	Recent advances in nanotheranostics for triple negative breast cancer treatment
title_short	Recent advances in nanotheranostics for triple negative breast cancer treatment
title_full	Recent advances in nanotheranostics for triple negative breast cancer treatment
title_fullStr	Recent advances in nanotheranostics for triple negative breast cancer treatment
title_full_unstemmed	Recent advances in nanotheranostics for triple negative breast cancer treatment
title_sort	recent advances in nanotheranostics for triple negative breast cancer treatment
publisher	BioMed Central Ltd.
publishDate	2019
url	http://umpir.ump.edu.my/id/eprint/26625/ http://umpir.ump.edu.my/id/eprint/26625/ http://umpir.ump.edu.my/id/eprint/26625/ http://umpir.ump.edu.my/id/eprint/26625/1/Recent%20advances%20in%20nanotheranostics%20for%20triple%20negative%20breast.pdf
first_indexed	2023-09-18T22:41:33Z
last_indexed	2023-09-18T22:41:33Z
_version_	1777416949098086400

Recent advances in nanotheranostics for triple negative breast cancer treatment

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