Effects of stent design on LDL accumulation at the carotid artery bifurcation

Effects of stent design on LDL accumulation at the carotid artery bifurcation

Restenosis typically occurs in regions of low and oscillating wall shear stress which also favours the accumulation of atherogenic macromolecules such as low-density lipoprotein (LDL). This study aims to determine how stent strut design may affect in-stent restenosis at the carotid artery bifurcati...

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Main Authors: Nasrul Hadi, Johari, Menichini, Claudia, Hamady, Mohamad, Xu, Xiao Y.
Format: Conference or Workshop Item
Language:English
English
Published: Universiti Malaysia Pahang 2019
Subjects:
TJ Mechanical engineering and machinery
Online Access:http://umpir.ump.edu.my/id/eprint/26483/
http://umpir.ump.edu.my/id/eprint/26483/1/75.%20Effects%20of%20stent%20design%20on%20ldl%20accumulation.pdf
http://umpir.ump.edu.my/id/eprint/26483/2/75.1%20Effects%20of%20stent%20design%20on%20ldl%20accumulation.pdf
id ump-26483
recordtype eprints
spelling ump-264832019-12-23T07:19:12Z http://umpir.ump.edu.my/id/eprint/26483/ Effects of stent design on LDL accumulation at the carotid artery bifurcation Nasrul Hadi, Johari Menichini, Claudia Hamady, Mohamad Xu, Xiao Y. TJ Mechanical engineering and machinery Restenosis typically occurs in regions of low and oscillating wall shear stress which also favours the accumulation of atherogenic macromolecules such as low-density lipoprotein (LDL). This study aims to determine how stent strut design may affect in-stent restenosis at the carotid artery bifurcation following carotid artery stenting (CAS) by means of computational simulation. LDL concentrations were compared for post-stent carotid and the contralateral models reconstructed from patient-specific images. Our results show that closed-cell stent designs are more likely to create atheroprone and procoagulant flow conditions than open-cell designs due to larger area exposed to high LDL concentration. Universiti Malaysia Pahang 2019 Conference or Workshop Item PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/26483/1/75.%20Effects%20of%20stent%20design%20on%20ldl%20accumulation.pdf pdf en http://umpir.ump.edu.my/id/eprint/26483/2/75.1%20Effects%20of%20stent%20design%20on%20ldl%20accumulation.pdf Nasrul Hadi, Johari and Menichini, Claudia and Hamady, Mohamad and Xu, Xiao Y. (2019) Effects of stent design on LDL accumulation at the carotid artery bifurcation. In: 6th International Conference on Computational and Mathematical Biomedical Engineering (CMBE 2019), 10-12 June 2019 , Japan. pp. 1-4.. (Unpublished)
repository_type Digital Repository
institution_category Local University
institution Universiti Malaysia Pahang
building UMP Institutional Repository
collection Online Access
language English
English
topic TJ Mechanical engineering and machinery
spellingShingle TJ Mechanical engineering and machinery
Nasrul Hadi, Johari
Menichini, Claudia
Hamady, Mohamad
Xu, Xiao Y.
Effects of stent design on LDL accumulation at the carotid artery bifurcation
description Restenosis typically occurs in regions of low and oscillating wall shear stress which also favours the accumulation of atherogenic macromolecules such as low-density lipoprotein (LDL). This study aims to determine how stent strut design may affect in-stent restenosis at the carotid artery bifurcation following carotid artery stenting (CAS) by means of computational simulation. LDL concentrations were compared for post-stent carotid and the contralateral models reconstructed from patient-specific images. Our results show that closed-cell stent designs are more likely to create atheroprone and procoagulant flow conditions than open-cell designs due to larger area exposed to high LDL concentration.
format Conference or Workshop Item
author Nasrul Hadi, Johari
Menichini, Claudia
Hamady, Mohamad
Xu, Xiao Y.
author_facet Nasrul Hadi, Johari
Menichini, Claudia
Hamady, Mohamad
Xu, Xiao Y.
author_sort Nasrul Hadi, Johari
title Effects of stent design on LDL accumulation at the carotid artery bifurcation
title_short Effects of stent design on LDL accumulation at the carotid artery bifurcation
title_full Effects of stent design on LDL accumulation at the carotid artery bifurcation
title_fullStr Effects of stent design on LDL accumulation at the carotid artery bifurcation
title_full_unstemmed Effects of stent design on LDL accumulation at the carotid artery bifurcation
title_sort effects of stent design on ldl accumulation at the carotid artery bifurcation
publisher Universiti Malaysia Pahang
publishDate 2019
url http://umpir.ump.edu.my/id/eprint/26483/
http://umpir.ump.edu.my/id/eprint/26483/1/75.%20Effects%20of%20stent%20design%20on%20ldl%20accumulation.pdf
http://umpir.ump.edu.my/id/eprint/26483/2/75.1%20Effects%20of%20stent%20design%20on%20ldl%20accumulation.pdf
first_indexed 2023-09-18T22:41:17Z
last_indexed 2023-09-18T22:41:17Z
_version_ 1777416931426435072

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