Effects of stent design on LDL accumulation at the carotid artery bifurcation
Restenosis typically occurs in regions of low and oscillating wall shear stress which also favours the accumulation of atherogenic macromolecules such as low-density lipoprotein (LDL). This study aims to determine how stent strut design may affect in-stent restenosis at the carotid artery bifurcati...
| Main Authors: | , , , |
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| Format: | Conference or Workshop Item |
| Language: | English English |
| Published: |
Universiti Malaysia Pahang
2019
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| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/26483/ http://umpir.ump.edu.my/id/eprint/26483/1/75.%20Effects%20of%20stent%20design%20on%20ldl%20accumulation.pdf http://umpir.ump.edu.my/id/eprint/26483/2/75.1%20Effects%20of%20stent%20design%20on%20ldl%20accumulation.pdf |
| Summary: | Restenosis typically occurs in regions of low and oscillating wall shear stress which also favours
the accumulation of atherogenic macromolecules such as low-density lipoprotein (LDL). This study aims to determine how stent strut design may affect in-stent restenosis at the carotid artery bifurcation following carotid artery stenting (CAS) by means of computational simulation. LDL concentrations were compared for post-stent carotid and the contralateral models reconstructed from patient-specific images. Our results show that closed-cell stent designs are more likely to create atheroprone and procoagulant flow conditions than open-cell designs due to larger area exposed to high LDL concentration. |
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