Evaluation of the co-delivery of diagnostic and therapeutic agents in polymeric micelles for triple negative breats cancer treatment

Triple-negative breast cancer (TNBC) is characterized by its higher incidence of recurrence and more aggressive clinical course. Due to higher rate of recurrence, early detection is urgently needed as well as an effective delivery of anticancer drug to tumor sites to increase patient survival. In th...

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Main Authors:	Nurul Issttifa Iyah, Aminuddin, Rajaletchumy, Veloo Kutty
Format:	Conference or Workshop Item
Language:	English
Published:	Universiti Malaysia Pahang 2019
Subjects:	T Technology (General)
Online Access:	http://umpir.ump.edu.my/id/eprint/26446/ http://umpir.ump.edu.my/id/eprint/26446/1/41.1%20Evaluation%20of%20the%20co-delivery%20of%20diagnostic%20and%20therapeutic.pdf

id	ump-26446
recordtype	eprints
spelling	ump-264462019-12-23T03:13:00Z http://umpir.ump.edu.my/id/eprint/26446/ Evaluation of the co-delivery of diagnostic and therapeutic agents in polymeric micelles for triple negative breats cancer treatment Nurul Issttifa Iyah, Aminuddin Rajaletchumy, Veloo Kutty T Technology (General) Triple-negative breast cancer (TNBC) is characterized by its higher incidence of recurrence and more aggressive clinical course. Due to higher rate of recurrence, early detection is urgently needed as well as an effective delivery of anticancer drug to tumor sites to increase patient survival. In this study, we develop theranostic nanoparticles loaded with anticancer drug (docetaxel) and diagnostic agent (iron oxide) to achieve simultaneous effect of therapeutic and diagnostic. Vitamin E TPGS was used as the nanocarriers, it has amphiphilic structure which is useful in the preparation of nanoparticles to encapsulate hydrophobic drug. This docetaxel-iron oxide loaded TPGS micelles were synthesized using solvent casting method. These micelles were characterized for its nanoparticles properties such as size, surface charge, morphology and drug loading. The synthesized micelles size found to be between the range of 15nm and 100nm for single drug and dual drug loading respectively. These micelles have uniform size distribution with polydispersity index less than 0.3. The surface charged of the micelles is negative between -7 mV and -20 mV. Whereas, the micelles have smooth spherical shape as observed under cryo-TEM. Overall, our micelles have higher drug loading which is suitable to use for effective delivery for triple negative breast cancer treatment. Universiti Malaysia Pahang 2019 Conference or Workshop Item PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/26446/1/41.1%20Evaluation%20of%20the%20co-delivery%20of%20diagnostic%20and%20therapeutic.pdf Nurul Issttifa Iyah, Aminuddin and Rajaletchumy, Veloo Kutty (2019) Evaluation of the co-delivery of diagnostic and therapeutic agents in polymeric micelles for triple negative breats cancer treatment. In: 20th World Conference on Applied Sciences, Engineering, and Technology, 26-27 June 2019 , Kuala Lumpur, Malaysia. pp. 1-2.. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	T Technology (General)
spellingShingle	T Technology (General) Nurul Issttifa Iyah, Aminuddin Rajaletchumy, Veloo Kutty Evaluation of the co-delivery of diagnostic and therapeutic agents in polymeric micelles for triple negative breats cancer treatment
description	Triple-negative breast cancer (TNBC) is characterized by its higher incidence of recurrence and more aggressive clinical course. Due to higher rate of recurrence, early detection is urgently needed as well as an effective delivery of anticancer drug to tumor sites to increase patient survival. In this study, we develop theranostic nanoparticles loaded with anticancer drug (docetaxel) and diagnostic agent (iron oxide) to achieve simultaneous effect of therapeutic and diagnostic. Vitamin E TPGS was used as the nanocarriers, it has amphiphilic structure which is useful in the preparation of nanoparticles to encapsulate hydrophobic drug. This docetaxel-iron oxide loaded TPGS micelles were synthesized using solvent casting method. These micelles were characterized for its nanoparticles properties such as size, surface charge, morphology and drug loading. The synthesized micelles size found to be between the range of 15nm and 100nm for single drug and dual drug loading respectively. These micelles have uniform size distribution with polydispersity index less than 0.3. The surface charged of the micelles is negative between -7 mV and -20 mV. Whereas, the micelles have smooth spherical shape as observed under cryo-TEM. Overall, our micelles have higher drug loading which is suitable to use for effective delivery for triple negative breast cancer treatment.
format	Conference or Workshop Item
author	Nurul Issttifa Iyah, Aminuddin Rajaletchumy, Veloo Kutty
author_facet	Nurul Issttifa Iyah, Aminuddin Rajaletchumy, Veloo Kutty
author_sort	Nurul Issttifa Iyah, Aminuddin
title	Evaluation of the co-delivery of diagnostic and therapeutic agents in polymeric micelles for triple negative breats cancer treatment
title_short	Evaluation of the co-delivery of diagnostic and therapeutic agents in polymeric micelles for triple negative breats cancer treatment
title_full	Evaluation of the co-delivery of diagnostic and therapeutic agents in polymeric micelles for triple negative breats cancer treatment
title_fullStr	Evaluation of the co-delivery of diagnostic and therapeutic agents in polymeric micelles for triple negative breats cancer treatment
title_full_unstemmed	Evaluation of the co-delivery of diagnostic and therapeutic agents in polymeric micelles for triple negative breats cancer treatment
title_sort	evaluation of the co-delivery of diagnostic and therapeutic agents in polymeric micelles for triple negative breats cancer treatment
publisher	Universiti Malaysia Pahang
publishDate	2019
url	http://umpir.ump.edu.my/id/eprint/26446/ http://umpir.ump.edu.my/id/eprint/26446/1/41.1%20Evaluation%20of%20the%20co-delivery%20of%20diagnostic%20and%20therapeutic.pdf
first_indexed	2023-09-18T22:41:12Z
last_indexed	2023-09-18T22:41:12Z
_version_	1777416926299947008

Evaluation of the co-delivery of diagnostic and therapeutic agents in polymeric micelles for triple negative breats cancer treatment

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