Antioxidant and antiproliferative activities of the extracts of Hypsizygus tessellatus (brown and white var.) and Flammulina velutipes cap

Cancer is a burning issue in the world today as high mortality rates are associated with it. The World Health Organization (WHO) has advocated exploration of natural products as the alternative measure for cancer management as the synthetic drugs has very strong side effect. Thus, this study investi...

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Main Authors:	Rashid, Shah Samiur, Ukaegbu, Chinonso Ishmael, Hazrulrizawati, Hamid, Mohd Hasbi, Ab. Rahim, Zaidul, I. S. M.
Format:	Conference or Workshop Item
Language:	English English
Published:	2019
Subjects:	QC Physics
Online Access:	http://umpir.ump.edu.my/id/eprint/26440/ http://umpir.ump.edu.my/id/eprint/26440/1/38.%20Antioxidant%20and%20antiproliferative%20activities%20of%20the%20extracts.pdf http://umpir.ump.edu.my/id/eprint/26440/2/38.1%20Antioxidant%20and%20antiproliferative%20activities%20of%20the%20extracts.pdf

id	ump-26440
recordtype	eprints
spelling	ump-264402020-02-26T03:01:42Z http://umpir.ump.edu.my/id/eprint/26440/ Antioxidant and antiproliferative activities of the extracts of Hypsizygus tessellatus (brown and white var.) and Flammulina velutipes cap Rashid, Shah Samiur Ukaegbu, Chinonso Ishmael Hazrulrizawati, Hamid Mohd Hasbi, Ab. Rahim Zaidul, I. S. M. QC Physics Cancer is a burning issue in the world today as high mortality rates are associated with it. The World Health Organization (WHO) has advocated exploration of natural products as the alternative measure for cancer management as the synthetic drugs has very strong side effect. Thus, this study investigated the antiproliferative effects of water and methanol extracts of the caps of three mushrooms (two variants of Hypsizygus tessellatus and Flammulina velutipes) against two breast cancer cell lines. In addition to the antiproliferation study, phytochemical identification and anti-oxidant investigation was also conducted. The phytochemical compositions of the extracts were identified using mass spectroscopy (UPLC-QTOF/MS). From the obtained results, the water extracts of F. velutipes (Enoki) and white H. tessellatus (Bunapi shimeji) caps showed higher radical scavenging activities against DPPH free radicals and H2O2 compared to the methanol fractions. accordingly, the same extracts showed a good ferric reducing antioxidant power against ferric ions. Finally, the extracts showed considerable levels of antiproliferative activities against the breast cancer cells (MCF-7 and MDA-MB-231). Therefore, the findings suggest that the presence of different phytochemicals (polyphenols, alkaloids) become reactive synergistically to eliminate free radicals from the body and help to prevent the development of free radicals-related diseases like cancer. 2019 Conference or Workshop Item PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/26440/1/38.%20Antioxidant%20and%20antiproliferative%20activities%20of%20the%20extracts.pdf pdf en http://umpir.ump.edu.my/id/eprint/26440/2/38.1%20Antioxidant%20and%20antiproliferative%20activities%20of%20the%20extracts.pdf Rashid, Shah Samiur and Ukaegbu, Chinonso Ishmael and Hazrulrizawati, Hamid and Mohd Hasbi, Ab. Rahim and Zaidul, I. S. M. (2019) Antioxidant and antiproliferative activities of the extracts of Hypsizygus tessellatus (brown and white var.) and Flammulina velutipes cap. In: International Conference on Environment and Life Science (ICENLISC-19), 21 May 2019 , Sydney, Australia. pp. 1-20.. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English English
topic	QC Physics
spellingShingle	QC Physics Rashid, Shah Samiur Ukaegbu, Chinonso Ishmael Hazrulrizawati, Hamid Mohd Hasbi, Ab. Rahim Zaidul, I. S. M. Antioxidant and antiproliferative activities of the extracts of Hypsizygus tessellatus (brown and white var.) and Flammulina velutipes cap
description	Cancer is a burning issue in the world today as high mortality rates are associated with it. The World Health Organization (WHO) has advocated exploration of natural products as the alternative measure for cancer management as the synthetic drugs has very strong side effect. Thus, this study investigated the antiproliferative effects of water and methanol extracts of the caps of three mushrooms (two variants of Hypsizygus tessellatus and Flammulina velutipes) against two breast cancer cell lines. In addition to the antiproliferation study, phytochemical identification and anti-oxidant investigation was also conducted. The phytochemical compositions of the extracts were identified using mass spectroscopy (UPLC-QTOF/MS). From the obtained results, the water extracts of F. velutipes (Enoki) and white H. tessellatus (Bunapi shimeji) caps showed higher radical scavenging activities against DPPH free radicals and H2O2 compared to the methanol fractions. accordingly, the same extracts showed a good ferric reducing antioxidant power against ferric ions. Finally, the extracts showed considerable levels of antiproliferative activities against the breast cancer cells (MCF-7 and MDA-MB-231). Therefore, the findings suggest that the presence of different phytochemicals (polyphenols, alkaloids) become reactive synergistically to eliminate free radicals from the body and help to prevent the development of free radicals-related diseases like cancer.
format	Conference or Workshop Item
author	Rashid, Shah Samiur Ukaegbu, Chinonso Ishmael Hazrulrizawati, Hamid Mohd Hasbi, Ab. Rahim Zaidul, I. S. M.
author_facet	Rashid, Shah Samiur Ukaegbu, Chinonso Ishmael Hazrulrizawati, Hamid Mohd Hasbi, Ab. Rahim Zaidul, I. S. M.
author_sort	Rashid, Shah Samiur
title	Antioxidant and antiproliferative activities of the extracts of Hypsizygus tessellatus (brown and white var.) and Flammulina velutipes cap
title_short	Antioxidant and antiproliferative activities of the extracts of Hypsizygus tessellatus (brown and white var.) and Flammulina velutipes cap
title_full	Antioxidant and antiproliferative activities of the extracts of Hypsizygus tessellatus (brown and white var.) and Flammulina velutipes cap
title_fullStr	Antioxidant and antiproliferative activities of the extracts of Hypsizygus tessellatus (brown and white var.) and Flammulina velutipes cap
title_full_unstemmed	Antioxidant and antiproliferative activities of the extracts of Hypsizygus tessellatus (brown and white var.) and Flammulina velutipes cap
title_sort	antioxidant and antiproliferative activities of the extracts of hypsizygus tessellatus (brown and white var.) and flammulina velutipes cap
publishDate	2019
url	http://umpir.ump.edu.my/id/eprint/26440/ http://umpir.ump.edu.my/id/eprint/26440/1/38.%20Antioxidant%20and%20antiproliferative%20activities%20of%20the%20extracts.pdf http://umpir.ump.edu.my/id/eprint/26440/2/38.1%20Antioxidant%20and%20antiproliferative%20activities%20of%20the%20extracts.pdf
first_indexed	2023-09-18T22:41:11Z
last_indexed	2023-09-18T22:41:11Z
_version_	1777416925422288896

Antioxidant and antiproliferative activities of the extracts of Hypsizygus tessellatus (brown and white var.) and Flammulina velutipes cap

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