Optimization of aceclofenac proniosomes by using different carriers, Part 1 : development and characterization

In the contemporary medical model world, the proniosomal system has been serving as a new drug delivery system that is considered to significantly enhance the bioavailability of drugs with low water solubility. The application of this system can improve the bioavailability of aceclofenac that is use...

Full description

Bibliographic Details
Main Authors:	Sammour, Rana M.F., Taher, Muhammad, Chatterjee, Bappaditya, Shahiwala, Aliasgar, Mahmood, Syed
Format:	Article
Language:	English
Published:	MDPI 2019
Subjects:	RS Pharmacy and materia medica TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/26270/ http://umpir.ump.edu.my/id/eprint/26270/ http://umpir.ump.edu.my/id/eprint/26270/ http://umpir.ump.edu.my/id/eprint/26270/1/Optimization%20of%20aceclofenac%20proniosomes%20by%20using%20different%20carriers.pdf

id	ump-26270
recordtype	eprints
spelling	ump-262702019-12-09T01:29:43Z http://umpir.ump.edu.my/id/eprint/26270/ Optimization of aceclofenac proniosomes by using different carriers, Part 1 : development and characterization Sammour, Rana M.F. Taher, Muhammad Chatterjee, Bappaditya Shahiwala, Aliasgar Mahmood, Syed RS Pharmacy and materia medica TP Chemical technology In the contemporary medical model world, the proniosomal system has been serving as a new drug delivery system that is considered to significantly enhance the bioavailability of drugs with low water solubility. The application of this system can improve the bioavailability of aceclofenac that is used for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. The present study is intended to develop an optimized proniosomal aceclofenac formula by the use of different carriers. Aceclofenac proniosomes have been prepared by slurry method, and different carriers such as maltodextrin, mannitol, and glucose were tried. Prepared proniosomes characterized by differential scanning calorimetry (DSC) analysis and Fourier transform infrared (FTIR) analysis revealed the compatibility of the drug chosen with the ingredient added, powder X-ray diffractometry (XRD) confirmed the amorphous phase of the prepared proniosomes, and finally, the surfactant layer was observed by scanning electron microscopy (SEM). Aceclofenac physical state transformations were confirmed with all formulas but maltodextrin proniosomes exhibited solubility more than other formulations. HPLC method has been used to analyze the niosomes derived from proniosomes in terms of their entrapment capability and drug content. The obtained results revealed that aceclofenac proniosomes can be successfully prepared by using different carriers. MDPI 2019-07-18 Article PeerReviewed pdf en cc_by_4 http://umpir.ump.edu.my/id/eprint/26270/1/Optimization%20of%20aceclofenac%20proniosomes%20by%20using%20different%20carriers.pdf Sammour, Rana M.F. and Taher, Muhammad and Chatterjee, Bappaditya and Shahiwala, Aliasgar and Mahmood, Syed (2019) Optimization of aceclofenac proniosomes by using different carriers, Part 1 : development and characterization. Pharmaceutics, 11 (7). pp. 1-19. ISSN 1999-4923 https://doi.org/10.3390/pharmaceutics11070350 https://doi.org/10.3390/pharmaceutics11070350
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica TP Chemical technology
spellingShingle	RS Pharmacy and materia medica TP Chemical technology Sammour, Rana M.F. Taher, Muhammad Chatterjee, Bappaditya Shahiwala, Aliasgar Mahmood, Syed Optimization of aceclofenac proniosomes by using different carriers, Part 1 : development and characterization
description	In the contemporary medical model world, the proniosomal system has been serving as a new drug delivery system that is considered to significantly enhance the bioavailability of drugs with low water solubility. The application of this system can improve the bioavailability of aceclofenac that is used for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. The present study is intended to develop an optimized proniosomal aceclofenac formula by the use of different carriers. Aceclofenac proniosomes have been prepared by slurry method, and different carriers such as maltodextrin, mannitol, and glucose were tried. Prepared proniosomes characterized by differential scanning calorimetry (DSC) analysis and Fourier transform infrared (FTIR) analysis revealed the compatibility of the drug chosen with the ingredient added, powder X-ray diffractometry (XRD) confirmed the amorphous phase of the prepared proniosomes, and finally, the surfactant layer was observed by scanning electron microscopy (SEM). Aceclofenac physical state transformations were confirmed with all formulas but maltodextrin proniosomes exhibited solubility more than other formulations. HPLC method has been used to analyze the niosomes derived from proniosomes in terms of their entrapment capability and drug content. The obtained results revealed that aceclofenac proniosomes can be successfully prepared by using different carriers.
format	Article
author	Sammour, Rana M.F. Taher, Muhammad Chatterjee, Bappaditya Shahiwala, Aliasgar Mahmood, Syed
author_facet	Sammour, Rana M.F. Taher, Muhammad Chatterjee, Bappaditya Shahiwala, Aliasgar Mahmood, Syed
author_sort	Sammour, Rana M.F.
title	Optimization of aceclofenac proniosomes by using different carriers, Part 1 : development and characterization
title_short	Optimization of aceclofenac proniosomes by using different carriers, Part 1 : development and characterization
title_full	Optimization of aceclofenac proniosomes by using different carriers, Part 1 : development and characterization
title_fullStr	Optimization of aceclofenac proniosomes by using different carriers, Part 1 : development and characterization
title_full_unstemmed	Optimization of aceclofenac proniosomes by using different carriers, Part 1 : development and characterization
title_sort	optimization of aceclofenac proniosomes by using different carriers, part 1 : development and characterization
publisher	MDPI
publishDate	2019
url	http://umpir.ump.edu.my/id/eprint/26270/ http://umpir.ump.edu.my/id/eprint/26270/ http://umpir.ump.edu.my/id/eprint/26270/ http://umpir.ump.edu.my/id/eprint/26270/1/Optimization%20of%20aceclofenac%20proniosomes%20by%20using%20different%20carriers.pdf
first_indexed	2023-09-18T22:40:48Z
last_indexed	2023-09-18T22:40:48Z
_version_	1777416901847154688

Optimization of aceclofenac proniosomes by using different carriers, Part 1 : development and characterization

Similar Items