Effect of Solvents and Crystallization Methods on the Formation of Carbamazepine-Saccharin Co-Crystal

Active Pharmaceutical Ingredients (API) crystallized in its co-crystal form is believed to be able to improve the physicochemical properties of its pure crystal. Carbamazepine (CBZ) and saccharin (SAC) were used in this study in investigation of effect of solvents and crystallization methods on the...

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Main Authors:	Fatinah, Ab Rahman, E. N., Engku Mat Nasir, Syarifah, Abd Rahim, Raihana Z., Edros, Nornizar, Anuar
Format:	Article
Language:	English
Published:	Science Publishing Corporation 2018
Subjects:	TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/25796/ http://umpir.ump.edu.my/id/eprint/25796/ http://umpir.ump.edu.my/id/eprint/25796/1/Effect%20of%20Solvents%20and%20Crystallization%20Methods%20on%20the%20Formation%20of%20Carbamazepine.pdf

id	ump-25796
recordtype	eprints
spelling	ump-257962019-09-04T02:26:37Z http://umpir.ump.edu.my/id/eprint/25796/ Effect of Solvents and Crystallization Methods on the Formation of Carbamazepine-Saccharin Co-Crystal Fatinah, Ab Rahman E. N., Engku Mat Nasir Syarifah, Abd Rahim Raihana Z., Edros Nornizar, Anuar TP Chemical technology Active Pharmaceutical Ingredients (API) crystallized in its co-crystal form is believed to be able to improve the physicochemical properties of its pure crystal. Carbamazepine (CBZ) and saccharin (SAC) were used in this study in investigation of effect of solvents and crystallization methods on the formation of CBZ-SAC co-crystal. There were four different solvents (acetonitrile, ethanol, ethyl acetate and propanol) and two crystallization methods (slurry and stirring crystallization) used in this study. The crystals produced were characterized by Differential Scanning Calorimetry (DSC), Powder X-Ray Diffraction (PXRD), Fourier Transform Infrared (FTIR) and optical microscopy. The findings revealed that only Form I of CBZ-SAC co-crystals was successfully formed for all parameters under studied. It was concluded that the type of solvents, crystallization methods and CBZ:SAC ratio used in this study did not play an important role on the CBZ-SAC Form I co-crystal formation for this system. Science Publishing Corporation 2018 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/25796/1/Effect%20of%20Solvents%20and%20Crystallization%20Methods%20on%20the%20Formation%20of%20Carbamazepine.pdf Fatinah, Ab Rahman and E. N., Engku Mat Nasir and Syarifah, Abd Rahim and Raihana Z., Edros and Nornizar, Anuar (2018) Effect of Solvents and Crystallization Methods on the Formation of Carbamazepine-Saccharin Co-Crystal. International Journal of Engineering & Technology, 7 (4.18). pp. 90-94. ISSN 2227-524X https://www.sciencepubco.com/index.php/ijet/article/view/21828
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Fatinah, Ab Rahman E. N., Engku Mat Nasir Syarifah, Abd Rahim Raihana Z., Edros Nornizar, Anuar Effect of Solvents and Crystallization Methods on the Formation of Carbamazepine-Saccharin Co-Crystal
description	Active Pharmaceutical Ingredients (API) crystallized in its co-crystal form is believed to be able to improve the physicochemical properties of its pure crystal. Carbamazepine (CBZ) and saccharin (SAC) were used in this study in investigation of effect of solvents and crystallization methods on the formation of CBZ-SAC co-crystal. There were four different solvents (acetonitrile, ethanol, ethyl acetate and propanol) and two crystallization methods (slurry and stirring crystallization) used in this study. The crystals produced were characterized by Differential Scanning Calorimetry (DSC), Powder X-Ray Diffraction (PXRD), Fourier Transform Infrared (FTIR) and optical microscopy. The findings revealed that only Form I of CBZ-SAC co-crystals was successfully formed for all parameters under studied. It was concluded that the type of solvents, crystallization methods and CBZ:SAC ratio used in this study did not play an important role on the CBZ-SAC Form I co-crystal formation for this system.
format	Article
author	Fatinah, Ab Rahman E. N., Engku Mat Nasir Syarifah, Abd Rahim Raihana Z., Edros Nornizar, Anuar
author_facet	Fatinah, Ab Rahman E. N., Engku Mat Nasir Syarifah, Abd Rahim Raihana Z., Edros Nornizar, Anuar
author_sort	Fatinah, Ab Rahman
title	Effect of Solvents and Crystallization Methods on the Formation of Carbamazepine-Saccharin Co-Crystal
title_short	Effect of Solvents and Crystallization Methods on the Formation of Carbamazepine-Saccharin Co-Crystal
title_full	Effect of Solvents and Crystallization Methods on the Formation of Carbamazepine-Saccharin Co-Crystal
title_fullStr	Effect of Solvents and Crystallization Methods on the Formation of Carbamazepine-Saccharin Co-Crystal
title_full_unstemmed	Effect of Solvents and Crystallization Methods on the Formation of Carbamazepine-Saccharin Co-Crystal
title_sort	effect of solvents and crystallization methods on the formation of carbamazepine-saccharin co-crystal
publisher	Science Publishing Corporation
publishDate	2018
url	http://umpir.ump.edu.my/id/eprint/25796/ http://umpir.ump.edu.my/id/eprint/25796/ http://umpir.ump.edu.my/id/eprint/25796/1/Effect%20of%20Solvents%20and%20Crystallization%20Methods%20on%20the%20Formation%20of%20Carbamazepine.pdf
first_indexed	2023-09-18T22:39:49Z
last_indexed	2023-09-18T22:39:49Z
_version_	1777416839205224448

Effect of Solvents and Crystallization Methods on the Formation of Carbamazepine-Saccharin Co-Crystal

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