Anti-diabetic activity and mineral elements evaluation of vernonia amygdalina leaves obtained from Malaysia

Diabetes has been characterized by transmuted lipids, hyperglycemia, proteins, and carbohydrates metabolism that can affect the quality of life. Although there are quite several synthetic drugs used in managing this disease, however, due to their side effects, the use of natural sources is imperativ...

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Main Authors:	Alara, Oluwaseun Ruth, Nour, A. H.
Format:	Article
Language:	English
Published:	Marmara University 2019
Subjects:	RA Public aspects of medicine RM Therapeutics. Pharmacology TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/25559/ http://umpir.ump.edu.my/id/eprint/25559/ http://umpir.ump.edu.my/id/eprint/25559/ http://umpir.ump.edu.my/id/eprint/25559/1/Anti-diabetic%20activity%20and%20mineral%20elements%20evaluation%20of%20vernonia.pdf

id	ump-25559
recordtype	eprints
spelling	ump-255592020-02-28T07:53:34Z http://umpir.ump.edu.my/id/eprint/25559/ Anti-diabetic activity and mineral elements evaluation of vernonia amygdalina leaves obtained from Malaysia Alara, Oluwaseun Ruth Nour, A. H. RA Public aspects of medicine RM Therapeutics. Pharmacology TP Chemical technology Diabetes has been characterized by transmuted lipids, hyperglycemia, proteins, and carbohydrates metabolism that can affect the quality of life. Although there are quite several synthetic drugs used in managing this disease, however, due to their side effects, the use of natural sources is imperative. This study focused on the in-vitro inhibitory activity of Vernonia amygdalina leaf grown in Malaysia using both α-amylase and α-glucosidase assays. The quantities of mineral elements in the plant extracts through microwave-assisted and Soxhlet extraction methods were as well examined through inductively coupled plasma mass spectrometry (ICP-MS) analysis. The extract of V. amygdalina leaf showed the highest dose-dependent effect of 97.28 and 98.08% of inhibition at 1.0 mg/mL having IC50 values of 0.51 mg/mL and 0.49 mg/mL against α-amylase and α-glucosidase enzymes, respectively. The inhibitory effects of the extract were higher than acarbose (a standard drug). Moreover, the results showed that higher quantities of mineral elements (potassium, magnesium, and calcium) and a lesser quantity of chromium in the extracts through microwave-assisted extraction (MAE) indicate that the technique possesses a higher capacity in obtaining higher mineral nutrients over Soxhlet extraction and more anti-diabetic activity of the extract. Thus, the extract exhibited an effective anti-diabetic activity which implies that it potentially serves as a natural source for managing diabetes. Marmara University 2019 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/25559/1/Anti-diabetic%20activity%20and%20mineral%20elements%20evaluation%20of%20vernonia.pdf Alara, Oluwaseun Ruth and Nour, A. H. (2019) Anti-diabetic activity and mineral elements evaluation of vernonia amygdalina leaves obtained from Malaysia. Marmara Pharmaceutical Journal, 23 (3). pp. 514-521. ISSN 1309-0801 https://doi.org/10.12991/jrp.2019.158 https://doi.org/10.12991/jrp.2019.158
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	RA Public aspects of medicine RM Therapeutics. Pharmacology TP Chemical technology
spellingShingle	RA Public aspects of medicine RM Therapeutics. Pharmacology TP Chemical technology Alara, Oluwaseun Ruth Nour, A. H. Anti-diabetic activity and mineral elements evaluation of vernonia amygdalina leaves obtained from Malaysia
description	Diabetes has been characterized by transmuted lipids, hyperglycemia, proteins, and carbohydrates metabolism that can affect the quality of life. Although there are quite several synthetic drugs used in managing this disease, however, due to their side effects, the use of natural sources is imperative. This study focused on the in-vitro inhibitory activity of Vernonia amygdalina leaf grown in Malaysia using both α-amylase and α-glucosidase assays. The quantities of mineral elements in the plant extracts through microwave-assisted and Soxhlet extraction methods were as well examined through inductively coupled plasma mass spectrometry (ICP-MS) analysis. The extract of V. amygdalina leaf showed the highest dose-dependent effect of 97.28 and 98.08% of inhibition at 1.0 mg/mL having IC50 values of 0.51 mg/mL and 0.49 mg/mL against α-amylase and α-glucosidase enzymes, respectively. The inhibitory effects of the extract were higher than acarbose (a standard drug). Moreover, the results showed that higher quantities of mineral elements (potassium, magnesium, and calcium) and a lesser quantity of chromium in the extracts through microwave-assisted extraction (MAE) indicate that the technique possesses a higher capacity in obtaining higher mineral nutrients over Soxhlet extraction and more anti-diabetic activity of the extract. Thus, the extract exhibited an effective anti-diabetic activity which implies that it potentially serves as a natural source for managing diabetes.
format	Article
author	Alara, Oluwaseun Ruth Nour, A. H.
author_facet	Alara, Oluwaseun Ruth Nour, A. H.
author_sort	Alara, Oluwaseun Ruth
title	Anti-diabetic activity and mineral elements evaluation of vernonia amygdalina leaves obtained from Malaysia
title_short	Anti-diabetic activity and mineral elements evaluation of vernonia amygdalina leaves obtained from Malaysia
title_full	Anti-diabetic activity and mineral elements evaluation of vernonia amygdalina leaves obtained from Malaysia
title_fullStr	Anti-diabetic activity and mineral elements evaluation of vernonia amygdalina leaves obtained from Malaysia
title_full_unstemmed	Anti-diabetic activity and mineral elements evaluation of vernonia amygdalina leaves obtained from Malaysia
title_sort	anti-diabetic activity and mineral elements evaluation of vernonia amygdalina leaves obtained from malaysia
publisher	Marmara University
publishDate	2019
url	http://umpir.ump.edu.my/id/eprint/25559/ http://umpir.ump.edu.my/id/eprint/25559/ http://umpir.ump.edu.my/id/eprint/25559/ http://umpir.ump.edu.my/id/eprint/25559/1/Anti-diabetic%20activity%20and%20mineral%20elements%20evaluation%20of%20vernonia.pdf
first_indexed	2023-09-18T22:39:18Z
last_indexed	2023-09-18T22:39:18Z
_version_	1777416807450148864

Anti-diabetic activity and mineral elements evaluation of vernonia amygdalina leaves obtained from Malaysia

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